Mechanism of vinegar cures depression & psychosis

    Frank Li   Sep 11 2026

https://blog.creaders.net/user_blog_diary.php?did=NTY4MzA0

During the last century, in Canada, Dr. Abram Hoffer using megadose niacinamide or niacin (He named as Vitamin B3) cured schizophrenia; and which promoted the birth of the Orthomolecular Medicine. Now, the therapeutic mechanism was revealed.

Vinegar improved symptoms of depression by rising niacin

In 2024, study reports Daily Vinegar Ingestion Improves Depression and Enhances Niacin Metabolism in Overweight Adults: A Randomized Controlled Trial.

Twice daily 2.95 g vinegar icreased niacin by 86% in the metabolites to have  improved self-reported depression symptomology in generally healthy adults; which showed that alterations in niacin metabolism may factor into this improvement.

Vinegar can treat diseases by improving gut microbiota.

The increasing of the niacin needs the help of gut microbiota or gut bacteria; the  operators at the Human Nutrition Factory. They are taking charge of processing and assembling the ingested food into the necessary nutrients or the basic components of human body that can be absorbed.

In 2023, study reports that Beneficial effect of vinegar consumption associated with regulating gut microbiome and metabolome: Vinegar interacts with gut microbiotaby shifting microbial populations, altering metabolic pathways, and helping regulate gut inflammation. 

Human digestive system - Gut is the second brain in producing 95% of Serotonin, neurons and most neurotransmitters, transplanting gut bacteria from healthy mice cured sick one, transplanting gut bacteria from the mother made new born disease free, and cured kids with autism.

The gut-brain axis or the gut microbiota–brain axis that is composed of the central nervous system, autonomic nervous system, enteric nervous system, endocrine system, immune system, and gut microbiota.

It is a two-way biochemical and neural communication network linking the gastrointestinal tract with the central nervous system.

Dysbiosis (a disturbance in the microbiome balance) has been identified as one of the risk factors for neuropsychiatric illnesses such as depression, anxiety, autism spectrum disorder, Parkinson’s disease, and Alzheimer’s disease.

Therapeutic strategies aimed at the gut microbiota, such as probiotics, dietary modifications, probiotics, and fecal microbiota transplantation, and so forth, became populer for curing incurable diseases. Such as, Parkinson’s  and Alzheimer’s disease.

The interconection of Vingar, psychosis, and niacinamide 

Google by keyword: vinegar , psychosis, niacinamide

AI Overview

Vingar, psychosis, and niacinamide (a form of vitamin B3)intersect primarily through recent scientific findings in metabolomics and historical theories in orthomolecular psychiatry[1, 2]

Here is how these three concepts connect based on clinical research:

1. The Vinegar and Niacinamide Connection

Clinical trials, including a notable study from Arizona State University, discovered that daily liquid vinegar ingestion significantly increases serum niacinamide (nicotinamide) concentrations. [1, 2]

• The Mechanism: Consuming liquid vinegar (acetic acid) upregulates the NAD+ salvage pathway.

• The Result: This metabolic shift caused an average 86% increase in niacinamide levels in participants, which directly correlated with a significant reduction in depressive symptoms. [1, 2, 3]

2. The Niacinamide and Psychosis Connection

The relationship between vitamin B3 (niacin or niacinamide) and psychosis centers on two medical areas:

• The Niacin Flushing Test: Psychiatrists use a skin test with niacin as a biological marker for schizophrenia and psychosis risk. Most healthy individuals experience temporary skin flushing (redness) from niacin. However, a significant subset of individuals with schizophrenia exhibit "niacin blunting"—an abnormally low or absent flushing response caused by disrupted prostaglandin and fatty acid signaling. [1, 2, 3, 4]

• Orthomolecular History: In the 1950s, a movement called orthomolecular psychiatry hypothesized that megadoses of vitamin B3 (niacin or niacinamide) could treat schizophrenia by altering adrenaline metabolism. While modern mainstream medicine treats psychosis with standardized antipsychotic medications, clinical researchers still study a rare "niacin-dependent" subset of psychiatric symptoms, such as severe niacin deficiency (pellagra), which can cause profound hallucinations, delusions, and psychosis. [1, 2, 3, 4]

Summary of the Intersection

Above was the AI Overview

Vinegar can kill virus by increases immune cells in the blood

2019, article Disinfect the Natural Way indicates that human immunity is by immune cells releasing Hypochlorous acid - HOCl kills viruses. So that since the birth of mammals, it is HOCl in functioning immunity.

2020, article Breadth of concomitant immune responses prior to patient recovery: a case report of non-severe COVID-19 reports that a COVID-19 sufferer self-recovered after the increase of immune cells in blood, which persisted for at least 7 d following full resolution of symptoms.

2001, article The effect of cider vinegar on some nutritional and physiological parameters in mice reports that mice were treated with daily oral doses of 0.17, 0.51 and 1.02 ml of the vinegar/kg body weight for 4 weeks. 

Raise immune cells: Hemoglobin (Hb), total erythrocyte counts (TEC) and total leukocyte counts (TLC) were raised in all treated groups. 

Weight reduction: Cider vinegar induced a significant reduction in weight gain in animals treated with 0.51 ml/kg. Others no differences in weight loss. 

Vinegar integrating melatonin will be the cure for all

We must follow TCM philosophy to view patient as emotional human from Western medicine viewd as nonhuman assembly; by restores Yin-Yang balance as treatment; then by body needed nutrients repairing ill and aging lesions; thus the cheaper handy dietary supplements will be the cure for all.

Vinegar can kill viruses, increase immune cells; to restore abnormal physiological indicators to normal; while melatonin promotes the regeneration of ill and aging nerve cells; immune cells, and stem cells of kidney failure, to regenerate system.

Vinegar and melatonin can both regulate the gut microbiota or gut bacteria.

My experience, water dilutes 5% vinegar x 18 ml (0.9g pure)/50kg + melatonin x 5-10mg daily once will be cure for all. Two times of vinegar cured my wife and son Covid-19. Vinegar + melatonin cured my wife Parkinson's for 25 years.

In days; I gave up 200-degree reading glasses, weeks; my facial skin rosy smooth, less wrinkles, digestion, energy, hearing, memory, and mental agility, etc., improved; show the renew in blood, vessels, microcirculation, younger 30 years.

Under TCM philosophy, Vinegar can kill all viruses; using it’s alone is able to empty the emergency room of hospitals; Vinegar + melatonin can cure the most diseases to empty hospitals. It is no western medicine made incurable. No Alzheimer'sAbram Hoffer (1917 – 2009) was a Canadian biochemist, physician, and psychiatrist known for his "adrenochrome hypothesis" of schizoaffective disorders. According to Hoffer, megavitamin therapy and other nutritional interventions are potentially effective treatments for schizophrenia and other diseases.[citation needed].

Abram Hoffer was also involved in studies of LSD as an experimental therapy for alcoholism; the discovery that high-dose niacin can be used to treat high cholesterol and other dyslipidemias.

Abram Hoffer named niacinamide or niacin as Vitamin B3 and uses megadose B3 to cure schizophrenia; the results were excellent.

William Wilson, the setter for promoting megavitamins

Bill Wilson (1895 – 1971), an alcoholic addiction. He was the co-founder of Alcoholics Anonymous (AA). AA is an international mutual aid fellowship with about 2 million members worldwide belonging to approximately 10,000 groups, associations, organizations, cooperatives, and fellowships of alcoholics helping other alcoholics achieve and maintain sobriety.

In 1960, New York, Abram Hoffer introduced to Bill that high-dose vitamins could help alcoholics. Bill started taking niacin 3 grams per day. Within weeks, the fatigue and depression that had afflicted him for years disappeared. He assigned niacin to his 30 good friends to try, and they all achieved the same effect. Then Bill promoted the use of megavitamins in AA.

Later, Bill was excluded from AA members. These Bill-appointed doctor members felt he had no reason to use vitamins as a cure. For this reason, in December 1965, he wrote to distribution to AA members, in which he used B-3, and the name B-3 is popular used now globally.

Wilson conduct a group of mentally ill alcoholic use B3, and result was satisfied, then wrote paper The Vitamin B-3 Therapy: A Promising Treatment for Schizophrenia – and its high relevance to the field of alcoholism in December 1965.

In 2003, I special went Centre for Addiction and Mental Health, CAMH Library, Toronto, copied the paper.

The cover is as follow. (A.A. - Alcoholics Anonymous).             

Dr. Linus Pawling, who named Orthomolecular Medicine

The paper inspired two-time Nobel Prize winner American chemist Dr. Linus Pauling, who coined Orthomolecular Medicine in his 1968 article Orthomolecular Psychiatry in the journal "Science" after read the paper of Bill Wilson.

Dr. Linus Carl Pawling 1901 –1994) was an American chemist, biochemist, chemical engineer, peace activist, author, and educator. He published more than 1,200 papers and books, of which about 850 dealt with scientific topics. New Scientist called him one of the 20 greatest scientists of all time, and as of 2000, he was rated the 16th most important scientist in history. For his scientific work, Pauling was awarded the Nobel Prize in Chemistry in 1954. For his peace activism, he was awarded the Nobel Peace Prize in 1962.

Pauling was one of the founders of the fields of quantum chemistry and molecular biology.[9] His contributions to the theory of the chemical bond include the concept of orbital hybridisation and the first accurate scale of electronegativities of the elements. Pauling also worked on the structures of biological molecules, and showed the importance of the alpha helix and beta sheet in protein secondary structure.

Pauling's approach combined methods and results from X-ray crystallography, molecular model building, and quantum chemistry. His discoveries inspired the work of James Watson, Francis Crick, and Rosalind Franklin on the structure of DNA, which in turn made it possible for geneticists to crack the DNA code of all organisms.

In his later years he promoted nuclear disarmament, as well as orthomolecular medicine, megavitamin therapy, and dietary supplements.

None of the latter have gained much acceptance in the mainstream scientific community, but got a lot of criticizing and being refused to fund his clinical trial.

Abram Hoffer; Bill Wilson & Linus Pauling were attacked 

Here I have to indicate the evil of Western medicine trained people, Dr. Abram Hoffer and Bill Wilson were both attacked due to advocate the use of B3 and ousted from their job position. Please Google online; there are still a lot of articles in condemning Linus Pauling regarding the use of the Orthomolecular Medicine.

Modern studies showed that Orthomolecular medicine has full cover therapeutic effects, such as:

The OM was originally intended to treat the “mental disease by the provision of the optimal molecular environment of the mind, especially the optimal concentrations of substances normally present in the human body.” OM currently is called as diet supplements that have developed many products, such as, Vitamins, minerals and so on.

Linus Paulin who published the Nature of the chemical bond in 1939. Later he did many pioneering works in understanding the nature of life from atomic structure, binding mode between atoms, nucleic acids and proteins. Whether from chemical, biological, and medical, he has laid a solid theoretical foundation.

Vitamin B-3 has wide range of physiological improvement functions. Its therapeutic process for psychotic is to restore damaged brain rather than as that of antipsychotic drugs control the abnormal secretions in the brain. Naturally, OM treats the diseases in a Holistic way. 

Although, for decades, some people have been eagerly trying to deny the curative effect of OM, however, the physiological improvement function is coming clearer in both clinic and academic. Now it gains extensively application world widely. Vitamin C was the one of OM, which was Linus Pauling strongly recommended, also was strongly opposed by others. following are some of new researches on Vitamin C.

1. Vitamin C Saves Lives! After Linus Pauling wrote his book on vitamin C in 1970, mortality from heart disease decreased 30-40% in the USA. From around 741,000 deaths per year to less than 500,000 deaths by 1986 - U. S. Bureau of National Health Statistics 1986.

2. Vitamin C may be useful to treat cancer after all.

3. Study shows vitamin C's cancer-fighting properties.

4. Vitamin C beneficial in cancer treatment – study.

5. How Vitamin C Stops Cancer.

In TCM, there are variety of nutritional constituents that are far more than that of in OM, which come from more than 10 thousands of plants, minerals and animals, such as, Ginseng, Gypsum and Placenta. They are certainly playing a significant role in the diseases treatment, but their unique contribution seems to have been ignored both clinically and academically. The reason may come from the TCM itself because that it never distinguishes the medicinal and nutritional, even without the concepts and terms, they were generally called as medicine.

In western medicine, Chinese medicinals generally called as alternative or diet supplements. I think that there is necessary to make a definition, such as, those with the effect of killing pathogenic agents should be called as medicinal, and those without the effect of killing pathogenic directly but with the role of physiological improvement should be called as nutritional, include those in Western medicine. A clear concept with a exact term will not only help clear describing, but also conducive to efficient thinking. 

The determination of a definition is difficult that need to be discussed carefully because of the ingredient of many single herbs is compound that contains both medicinal and nutritional. Even if a single constituent also has a dual role, such as, some peptide is nutritional but also an antibiotic. The nutritionals in Chinese medicinals is a promising medical potential to be an attractive research direction.