日志
Chinese Medicine can Reduce the harm of Stress
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Chinese Medicine can reduce the harm of Stress
Frank Li, Nov. 25, 2011, in Waterloo, Canada.
Contents
1.. Stress causes deterioration in everything
2.. Chinese medicine can reduce the negative effects of stress
2.1. The effect of single Chinese medicine on stress
2.2. The effect of compound Chinese medicine on stress
2.3.. The pharmacological research of Chinese medicine on stress
2.3.1.. Chinese Medicine multi-targeted without resistance
2.3.2.. Chinese medicine can make general physical enhancement
2.3.3.. Chinese Medicine can promote brain cells regeneration
2.3.3.1.. Promotion of nerve cell’s differentiation and development
2.3.3.2.. Promotion of neuronal growth
2.3.3.3.. Activation of undifferentiated stem cells
1.. Stress causes deterioration in everything
The study of crossing the disciplines of psychology, medicine, neuroscience, and genetics reveals that stress causes deterioration in everything from gums to heart and can make human more susceptible to everything from the common cold to cancer. And those optimistic people have lower incidence of heart disease, better prognosis after heart surgery, and longer life.
Nov. 30, 2004, a report that Prof. Dennis H. Novack at Drexel University College of Medicine in Philadelphia studied 39 women ages 20 to 50 who had been experiencing grinding stress for years because they were caring for a child suffering from a serious chronic illness, such as autism or cerebral palsy, and 19 other very similar women whose children were healthy. The Study Is First to Confirm That Stress Speeds Aging.
Now, many studies have made clear that our health is closely associated with psychological factors or so called stress, and it is the main inducement for various diseases. Such as obesity, cancer, diabetes, heart attack, stress ulcer, mental disorder, irritable bowel syndrome, retard the wound healing, and so on.
2. Chinese medicine can reduce the negative effects of stress
We are living in a highly competitive society. The inducing factors of psychological pressure are surrounding us in every moment, we can’t escape. Can be done only on the subjective self-regulating to reduce their harms. On this purpose, Chinese medicine can play a effective role.
2.1. The effect of single Chinese medicine on stress
Here, take Ginseng, a well-known herb as example:
For the rats in chronic restraint stress, Ginsenoside can reduce the pathological changes in ultra-structure of adrenal cortex, improve the reduction of activities, the decline in memory and exercise capacity, etc.
Ginseng can reduce the reduction of ATP, glycogen, creatine phosphate content and the increase of lactic acid content in the muscle tissue of rats in stress. Reduce the rise of mouse rectum temperature caused by the stimulation of noise and light.
Ginseng can significantly reduce the mortality of mice under the condition of low temperatures (-9 ℃) or high temperature (46 ℃). Extend the swimming duration time and inhibit the reduction of muscle glycogen in swimming rats.
2.2. The effect of compound Chinese medicine on stress
Aim: To study the effects of Banxia Houpu Soup and Guizhi Gancao Longgu Muli Soup on the behaviors and HPA axis of chronic psychological stress rats.
Methods: SD rats were divided into 5 groups: normal group, model groups Ⅰ and Ⅱ, Banxia Houpu Soup group and Guizhi Gancao Longgu Muli Soup group. The behavior, the hypothalamus CRH, plasma ACTH and serum CORT (radio-immunity method) of all the rats were observed.
Results: On the 11th day, the crossing times of model group Ⅰ and the crossing times and struggle time of model group Ⅱ changed obviously compared with those of normal group. On the 19th day, the crossing times and still time of model group Ⅰ and Ⅱ had remarkable differences, while the contents of CRH, ACTH of model group Ⅰ and the contents of CRH, ACTH and CORT of model group Ⅱ increased obviously compared with those of normal group. Compared with those of model group Ⅰ and Ⅱ, the crossing times on the 11th and 19th days and the struggle times on the 11th day of Banxia Houpu Soup group increased obviously, while the contents of CRH and ACTH decreased; the crossing times on the 19th day increased, but the still time on the 19th day shortened and thecontents of ACTH and CRH decreased in Guizhi Longgu Muli Soup.
Conclusion: Banxia Houpu Soup and Guizhi Longgu Muli Soup can affect the behavior and the endocrinal system of the chronic psychological stress rats in a certain level by through the action on the different sectors of the hypothalamus-pituitary-adrenal gland axis.
Note: Banxia Houpu Soup and Guizhi Longgu Muli Soup both are the experience compound prescription of Chinese medicine.
2.3.. The pharmacological research of Chinese medicine on stress
2.3.1.. Chinese Medicine multi-targeted without resistance
May 25, 2018, The Journal of Pharmaceutical Practice, vol. 36, No.3 published article The mechanism research on the pathogenesis of depression and the treatment of TCM on depression, following was the Abstract.
[Abstract] Depression is a serious health hazard and the World Health Organization predicts that depression will be the second leading cause of abnormal death and disability by 2020. Currently，most antidepressants are tricyclic antidepressants（TCA），tetracyclic antidepressants and selective ５HT reuptake inhibitors. Long term use of those medications will develop resistance and adverse reactions．In addition，drugs that block a single target are often hard to achieve therapeutic outcomes due to the biological abnormalities involving multiple systems in the body．
Traditional Chinese Medicine can simultaneously act on multiple targets to influence the disease network in many aspects at the same time．This approach has higher efficacy and lower side effects than a single chemical medication．Recently，there are increasing numbers of research papers on antidepressant mechanism of TMC，mainly focused on the release level of neurotransmitters，hippocampus brain derived neurotrophic factor（BDNF）expression and cytokines，etc．The latest researches also indicated that the gut microbiota has involved the development of emotional diseases and the diseases related to central nerves system．
Above reports indicated the advantage of Chinese medicine on the treatment of stress.
2.3.2.. Chinese medicine can make general physical enhancement
Stress is the result of comprehensive reaction of the body against the social pressure. Due to the social factors are often unexpectable and uncontrollable, therefore, that the enhancement of the physical ability against stress will be a feasible approach in the prevention and treatment of stress-related sleep disorders.
Many studies show that Chinese medicine can relieve the negative effects of psychological stress by releasing endorphins, decreases the stress hormone cortisol, eliminating the oxygen free radicals, lowers blood pressure, reduces heart rate, relaxes muscle tissue, improves the digestion and sleeping, and bring more fresh oxygen to body tissues by improving the circulation of blood and lymphatic fluids. This increased oxygen flow will eliminate waste products from inside the body and enhance the recovery from situation being impaired.
The danger of psychological stress is now the damage to physiological functions, especially the brain. Then, restoring physiological functions is also a kind of psychological stress reduction.
2.3.3.. Chinese Medicine can promote brain cells regeneration
Dec. 22, 2011, in the article Chinese Medicine and Cells Regeneration, I introduced that:
"Clinical practices have been demonstrating that Chinese medicine is superior to Western medicine in the treatment and prevention of brain disorders. Chinese Medicine can directly permeate through the blood-brain barrier into the brain to take the therapeutic effect in improving the state of hypoxic ischemic and metabolism. It will not only promote development of immature neurons, but also to repair the damaged nerve cells. Enhance the activity of nerve cells and restore the injured brain. Such as, Chinese medicines have very good therapeutic effect on the congenital cerebral palsy, sequela of cerebrovascular disease and traumatic brain injury as well as Alzheimer’s disease, etc."
"Chinese medicine contains various natural nutrients that are easily absorbed by our body, such as, amino acids, peptides, phospholipids and so on. So the treatment in Chinese medicine is able to generate magical effect that simply cannot get in the treatment of medication or surgery in Western medicine. Chinese medicine is a kind of restorative treatment in the level of cell and gene, through providing nutrients for the damaged nerve cells, to promote residual neurons regeneration. Therefore the damaged function of the nerve system will be restored."
2.3.3.1.. Promotion of nerve cell’s differentiation and development
"In vitro, vivo and clinical trials in the conditions of normal, hypoxic and glutamate damage, shows that Chinese medicine can increase cells’ activity, promote nerve cell’s differentiation and development. Inhibit the apoptosis of nerve cells in the earlier, middle and later stage, which induced by hypoxic and glutamate damage."
2.3.3.2.. Promotion of neuronal growth
"Neonatal rat’s dorsal root ganglia in serum-free culture, for the test group add the Chinese medicine in basic culture medium, control group add nothing. In the test group, the length of dorsal root ganglion cells neurites are (314 ± 43) μm. It is significantly larger than that of (76 ± 26) μm in control group. These results indicate that, in vitro, Chinese medicine can promote the growth of dorsal root ganglia and cerebral cortex neurons."
2.3.3.3.. Activation of undifferentiated stem cells
"In the central nervous system, there are some undifferentiated stem cells. Chinese medicine possesses the ability to activate those stem cells to split and regenerate new cells. So that make the nerve cells be restored to normal levels from original absolutely decreased status."
"Ischemic injured Brain, after 7 days’ treatment of Chinese medicine, in ischemic injured area, found a great number of nestin expressions. This showes that Chinese medicine possesses a strong ability to promote the proliferation of adult neural stem cells in vivo. The Experiments also observed that the functional recovery of patients’ limb is sync with the increase of nestin level. The results proved that the Chinese medicine can effectively promote the nestin expression. Therefore contribute to rebuild nerve tissue effectively after cerebral ischemia damage."
