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This article aims at helping people to understand Traditional Chinese medicine (TCM) by introducing its philosophy, medicinal materials, therapeutic mechanism and the achievements of modern studies on the bio-active ingredients, pharmacological effects of natural medicinals that used in TCM, so that people can willingly accept and enjoy this promising therapeutic approach for self-help in diseases treating and health keeping by private affordable OTC tablets Chinese medicinals, thus, live a happier life with lesser economic burden on health care by getting rid of fully relying on the expensive hospitals and synthetic medications, at the same time, to unload overloaded healthcare system, thereby reduce the pressure on government.
We
can develop new natural medicinal additives as daily diet to regulate human
body keeping in optimal healthy state, thereby reduce the occurrence of sicknesses,
as well, the increase in demand of natural medicinal resources will promote the
development of related industries in herbs’ planting and processing with the creation
of employment and revenue.
Important Note, since the writing of this article has
been lasting over 10 years, and the references used in article were mostly from
online, now, most of the original links have lapsed and it is no longer
possible to give the sources of the references.
Indeed,
this is not an academic article, but just the collection by editing the research results of others, with the hope to attract the
attention of people on Chinese medicine, thereby make such an important
cultural heritage of human civilization contribute to the improvement of human
health as a solution for countering the harm of over commercialization.
I would like to say sorry for my poor wording in English.
Contents
My understanding
about Chinese medicine
The barriers for the
popularization of Chinese medicine
3.1. Traditional
Chinese Medicine
3.1.1. The origin of
TCM, MCM and CM
3.1.3. The holistic
view of life of TCM
3.1.6. The difference
of TCM & WM
3.1.7. Example of
doctors’ work manner of TCM and WM
3.1.10. Chinese Drug
& Compound Prescription
3.3.1. Effective
evaluation of acupuncture
3.3.2. Meridian & Chinese medicines
4. Some application studies in natural medicinals
4.1. Phytomedicine
Research in Germany
4.2. Multi-Factorial
Cognitive Disorders
7. Drug
Mates
8. The treatment of some chronic diseases by Traditional
Chinese Medicine
8.1…Natural Medicine based on the theory of Traditional Chinese Medicine
8.2…The mental disorders are caused by brain atrophy
8.3…A psychotic with 10 years in illness cured by
Chinese medicines
8.3.1…The symptoms before and after treatment
8.3.2…The therapeutic mechanism analysis
8.3.3…My
confidence to help more psychotics
8.4…To
rescue depression by Traditional Chinese Medicine
8.4.1…The harsh reality that Canada is suffering in diseases of
depression
8.4.2…The magic effect of Chinese Medicine on
depression
8.5…To
cure Dementia by Traditional Chinese Medicine
8.6…Chinese Medicine Improve Sleep
8.7…Chinese Medicine can boost immune system
8.8…Chinese Medicine can Reduce Stress
8.9…Chinese Medicine and Heart Disease
8.10…Chinese Medicine can promote Wound Healing
8.11…Chinese Medicine treats on A H1N1 Flu 2009
8.12…No
death of SARS treated by Chinese Medicine
8.13…Chinese medicine can cure AIDS
8.14…Chinese medicine can cure cancer
8.15…Chinese medicine is effective in anti-aging
8.16…Chinese Medicine can improve kidney function
8.17…Chinese Medicine can improve Sexual Function
8.18…Chinese Medicine for Improving the Metabolism
8.19…Chinese medicine can promote recovery after operation
The dilemma in health care triggered the rise of Chinese medicine
My understanding about Chinese medicine
I
am a senior researcher on the profession of metal materials once worked in a
big Metal Research Institute of China; my career time was spent in Libraries
and Laboratories. Due to the particularity of scientific research, I have to search
and study latest scientific knowledge and technology for improving research
plan, so that I have to spend more time in Libraries than in Laboratories with
enough time and chance for free reading.
The
biggest gain of my research career was that I have been forced and exercised to
be able to calm the mind with an ability of long time concentrated on delving
into specific subject until being made clear.
Besides
my profession, I spent most of spare time on the study of Traditional Chinese
Medicine - TCM, especially, those modern studies on bioactive substances and
pharmacological effects of natural medicinal materials.
For well understanding Chinese medicine, we should understand its philosophy at first.
TCM has been developing under the guidance of Daoism (in Mandarin phonetic pronunciation or Taoism in Cantonese pronunciation) that is a Philosophy similar to Holism.
Daoism is symbolized by the Tai-Ji Diagram as following, in which the black fish represents the Yin, but its eyes are white that means yang, white fish represents Yang, but its eyes are black that means Yin. The outermost circle is called as Taiji or Wuji, which indicates that every thing universally is metaplasia from vitality and movement in cycling endlessly.
Photo
source: http://www.prayercast.com/daoism.html
The
whole symbol means that Yin can’t leave Yang, and Yang can’t leave Yin. They
are opposites of each other with contradiction and also reunification. Each is
understood to be an integral part of the others with coexistence that can’t exist
separately. The main task of Dao is to make Yin and Yang keep in the state of
harmonious balance.
Daoism dialectically views everything
is in the unity of opposites universally and the
universe is a system of the unity of opposites, which is composed of many
components - subsystem with own feature of unity of opposites. The components
are all in the state of dynamic balance through continuous self-regulation.
This primitive philosophical view generated thousands of years
ago is well coinciding with the modern science and nature world. For example:
In micro perspective, as small as atom, extranuclear electrons
cloud with the nucleus are both in the state of attraction and repulsion, the
electronics rotating around the nucleus in dynamic equilibrium. They are
in the state unity of opposites. Atoms are the components to compose of natural
materials.
In macro perspective, the planets with the sun in solar system,
and the solar system with other galaxies are all in the continuously
rotating in the state of self-regulation by attraction and repulsion of each
other. They are also in the state of dynamic equilibrium of unity of opposites.
Daoism views human life as one of such a component of unity of
opposites universally. It embodies that human body itself, human and
nature, human and society, human and spirit is all unified whole with
interacting each other.
Daoism
is contrary with Reductionism and consistent with systems biology.
Suppose that Reductionism focuses on a specific grass on the Himalayas, and
then the Daoism is not only focusing on the entire grass, but also concerning
those would affect the growth of grass, such as, destructive pests, the
greenhouse effect and the reduction of glacier cover, etc.
TCM
is an empirical medicine that based on thousands-years continuous written
records without the concepts and terms of modern anatomy and biology, but uses
the concepts and terms of the holistic philosophy – Daoism with viewing our
body as the organic whole with all parts are interconnected and in mutual
influenced; a well-balanced body can fight against any disease.
A well-balanced human bodies will form an
effective self-defence system that can handle the most of pathogenic agents. The
diseases could happen only if there are some unbalanced parts in a human body.
Therefore,
the treatments of Chinese medicine do not directly target on killing pathogens but target
on bring back the natural balance. It achieves the
purpose by natural therapeutic approaches, such as, natural drugs, acupuncture
and physical exercises, etc. In nature it is in improving appetite,
sleep, immunity, nutrition supply, blood circulation, cerebral blood supply,
and so on; which have achieved powerful therapeutic effect for incurable
degenerative disease, while western medicine has showed helpless due to they
are no pathogens for killing.
Under
the guidance of holistic philosophy Daoism, TCM has developed many natural
therapeutic methods, and identified about 11,146 plants, 1581 animals
and 80 minerals as medicinal use and developed nearly 100 thousands of
experience-based formulas, which covering almost all known diseases, through
long time trial and error clinically.
So,
now we learnt that calls Chinese medicine as herbal medicine was not exactly correct.
Modern
biochemical and pharmacological researches proved that Chinese medicine is
sorted scientifically according to the therapeutic effect. For example, those
are sorted as enhancing digestion are rich in Ca, Zn and Fe, and those as
enhancing male sexual ability are rich in Mn and Cu.
The
natural medicinal materials used in TCM have bioactive constituents with the
therapeutic effect that is similar to that of synthetic ones in killing the
pathogenic agents directly and the nutritional effect that is similar to that
of orthomolecular
medicine.
Some
of Chinese medicines can improve human immunity, such as, boosting the weight
gains of immune organs, increasing the number and activity of the phagocytes,
NK cells and so on.
Therefore,
in subjective viewing, the treatment of TCM is to regulate the physical
balance, but in objective practice, the process of the regulations were in
improving immune function, and thereby kills pathogens by strengthened defense
system.
More
valuable, Chinese medicine emphasizing that psychological factors play decisive
role in affecting human health with a long practice that treatment is seven
tenth in promoting psychological rehabilitation, only three tenth in
medication. Its correctness proved by modern
double-blinded-placebo cured rate 50-60% and many self-recovered incurable
cases.
1..
The people
who live in a normal life after damaged-half-brain was fully removed, MRI
scan found that some areas on remained brain has developed as the function of
disappeared brain.
2..
A British
stroke man who has been 'left to die” by doctors, but himself stood up in 6
months through moving bodies by will, which started from a big toe, then other
areas of body.
3.. The transplanted-cancer of rats disappeared or shrunk by group socially activities with large group of 25 in a larger room, but, has no changes for those rats were in small group of 5.
4.. A 10 years old British girl Kirsty Collier's heart grew back after a third was removed when she was in 4 months old.
Chinese
medicine can magnify the effect of psychotherapy by regulating physical
balance.
The
philosophy of Western medicine is the Reductionism that regards human body as
assembly of inanimate parts, the treatment is to find and kill pathogens, which
led it less effective for degenerative diseases. It is also increasingly
ineffective for infectious diseases, due to quick mutation of the virus, which
triggered the rise of TCM.
In
medicine field, the emergence of systems biology and evidence-based medicine
shows that medical philosophy has been quietly updating from Reductionism
towards Holism by gradually increasing the holistic ingredients.
Here,
the Chinese medicine is referring to those natural medicinal materials based on
modern studies according to TCM.
Recent
years, researchers globally, especially in China, have made great many
achievements in bioactive substances and their pharmacological effects on
natural Chinese medicine by modern
bio-technologies, instruments and methods as that of used in Western Medicine
from the level of molecular, protein and gene; and also, the
therapeutic mechanism of many ancestral experienced formulas were revealed.
The
findings on natural Chinese medicine were mostly published on medical journals.
Besides reading in Libraries, I also bought some books in compilation of research results,
subscribed to some journals, and selectively copied many articles in self
expense to be bound as books.
In
follow photos, the photo 1 and 2 one was some of the books and the photo 3 and
4 was the bound book and the example of one of copied pages from medical journals.
Photo1.Photo2.
The
book name in photo 1 was The Pharmacology and Clinical Application of Chinese
Medicine; the size of paper was in B5 with 752 pages, only Issued 3,000 copies
in 1999. It was the collections of the results of modern studies on
pharmacology and clinical application on 1070 of natural Chinese medicine by
using modern biotechnologies of Western medicine.
The
book name in photo 2 was The Trace Chemical Elements and Chinese Medicine; the
size of paper was in B5 with 483 pages, only issued 6,000 copies in 1993. It
was the collections of the results of modern studies on the Trace Chemical
Elements in natural Chinese Medicine.
As
minerals, the Chemical Elements was a significant part of Orthomolecular
medicine (OM)
that was coined by two times Nobel Laureate, Dr. Linus Paulin who was enlightened from the
successful practice of Canadian doctors cured mental
illness by megadose Vitamin B3, later,
I will discuss this issue further.
Modern
studies have found that chemical elements have an optimal range in the human
body. When an element is lower than this range, the diseases in elemental
deficiency will occur, which proved the correctness of the Orthomolecular
medicine. Natural
Chinese medicine is rich in chemical elements that are essential for human health,
which have very high clinical value for trace element deficiency.
In
compared with synthetic ones, the chemical elements in Chinese medicine have
the advantage of easy for absorption, less potential risks, such as oxidation,
deterioration and so on.
As
mentioned above, long time ago, Chinese medicine has identified about 80
minerals as medicinal use. Modern studies also revealed their pharmacological
effects, such as, the natural Chinese medicines that promote digestion are rich
in calcium, zinc, and iron, and those that promote sexual function, precocious
puberty and also promote height growth are rich in manganese and copper.
Now
the two books have been published for about two decades; in this period, the
achievements of new findings on natural Chinese medicine would be able to be
collected as new books in similar volume.
In
following, the photo 3 was a book that I selectively copied from various
periodicals of new studies on Chinese medicine in self expense, and photo 4 was
an example of one of copied pages. From cost concerning, the copied one was
more expensive.
Photo3.Photo4.
In
above pictures, the horseshoe alarm clock was intended as reference of
size-scale, so that the reader can easily feel the size of the book. The
horseshoe alarm clock was bought in Canada. When I was a child in 50 years ago,
in my home China, there was such a clock in the same structure and same size
but in different color, the old one was paint coated, and this one was made
shiny in stainless steel. I think that the horseshoe alarm clock would resonate
to great many readers with the old day of the life.
I
take those books and copies as valuable treasure. In the past years, I have
them with me. In this period, I once several times moved home, even when
immigrating to Canada, the entire family property has to be compressed into a
few suitcases and weighed accurate to grams, in those process, I have to throw
away a lot of favorite books, however, I never consider to discard the books in
natural Chinese medicine.
The
findings in pharmacological effects of Chinese medicine involving a wide range:
1. Boosting digestion.
2. Promoting sleep.
3. Balance-regulating endocrine.
4. Bidirectional regulating hormones.
5. Bidirectional regulating blood, which
can promote blood circulation and can also stop bleeding.
6. Bidirectional regulating central
nervous system from over-suppressed or over-excited.
7. Boosting the weight gains of immune
organs.
8. Increasing the number and activity of the Natural Killer cells.
9. Boosting the regeneration of cells.
10. Improving the health condition of cardiovascular
system and cerebrovascular system.
11. Dilating on blood vessels to increases
blood supply for heart and brain.
12. Improving the intima of blood
vessel and stomach.
13. Boosting the healing of wound.
14. Improve cognitive ability and
memory.
15. Treats dementia and Alzheimer's
disease.
16. Treats schizophrenia and
depression, and much more.
……
More
pleasing is that in China, with modern technologies, those experience-based
formulas have updated and used to produce great many OCT tablets and injections
by extracts, and labeled with the instructions of the sort of treated-diseases,
precautions and dosage. They are available in Chinese pharmacies
worldwide.
The
biggest advantages of traditional Chinese medicine are its efficacy, fewer side
effects, never produces drug resistance due to multiple components on multiple
targets in one dose. Moreover, OTC tablets are easy to use at home and inexpensive
affordable privately.
The
results of modern studies and OTC tablets medicines will help us easy
medicinal-selection for treating certain diseases according to the
pharmaceutical functions.
The
achievements in the modern studies on natural Chinese medicine have laid
profound foundation for the popularization of the public application of natural
Chinese medicine.
There were tablets OTC medicine reserved in my home as handy for use according to the descriptions on the labels.
I have met many times, in the pharmacy of Chinese medicine Toronto, there were some natural Chinese medicinals out of stock, and the clerk said that all were bought by local whites in one-time.
Obviously,
the fact shows that local patients in cardiovascular or cerebrovascular have
already experienced the good medical effects of this medicine. Compared with
western synthetic one, it is highly effective with no side effects and cheaper.
The
fact also shows that local patients are easily accepting Chinese medicine.
Indeed,
more meaningful is that clinical practices have shown that many degenerative chronic
diseases can be treated easily by the combo of OTC tablets without side effects,
such as, the depression, psychotic, Alzheimer's disease and so on, which are without
pathogenic sources, which Western medicine has been in less effect.
In
such a concern, in May 9, 2017 – July 18, 2017, I once searched information and
wrote article Chinese Medicine
can cure Schizophrenia and Alzheimer's disease.
Here,
my experiences are worth to mention.
In
China, the hospitals are mostly integrated by Western Medicine and Chinese
medicine, the patients can choose any one as personal will, but, the doctors in
Chinese medicine were all addicted in the experiences according to traditional theories
of TCM, with ignoring modern research on pharmacology of Chinese medicine.
When
I working in a research institute China, my colleagues and their families, if
the treatment were not effective in the hospital, they would seek the help from
me, I prepare medicinal combo by the OTC tablets of natural Chinese medicine according
to the results of modern pharmacological researches in buckshee, with amazing
curative results.
Later,
they introduced the medicinal combo to their relatives and friends, and asked
me to collect some cost fees; otherwise, they would refuse to accept anymore.
Since then, for the cost on buying medical books, I did not have to apply from
my wife; and also, I could order more medical journals.
Before I left China to Canada, I gave a lot of medical
journals of natural Chinese medicine to a friend who was a clinician in Western medicine. He used the methods and prescriptions that described in
the journals to treat patients and the effcets were wonderful.
Some of his unique usage were without research reports, I am
also worried about the safety of his medication; he explained that he treats
patients by two kind of injections in same time with a tee-type drop tube
seperately instead of mixing them in advance, it was effective without any
adverse reactions.
In Canada, I once cured a young man who was 10 years in psychotic by OCT tablets Chinese
medicine, only in weeks, his abnormal emotion was recovered as normal. The
amazing therapeutic effect shocked me also. See section A
psychotic with 10 years in illness cured by Chinese medicines.
The
successful practice in helping people made me experienced with firm confidence
in flexibly using Chinese medicine to treat a variety of diseases. The key lies
in the compound medication, which was the good use of synergistic effect by
putting a variety of medicines at same time.
This
article is not a professional writing but only for a popularity of therapeutic
approach in more curative effect, less negative effect, in handy and easy for
use, in cheaper and private-affordable for the people who have less income for
health care.
In this article, the data is limited,
and the readability in English wording is even more inadequate. Here, what I said
is not important; the important is in the limelight to attract people's
attention for willingly enjoying Chinese medicine.
The barriers for the popularization of Chinese medicine
For
a long time, the governments and individuals have been unable to cope with the
medical difficulties in Western medicine, even so, above good medicinal
references and easy available OTC tablets in Chinese medicine has been rare used
in mainstream clinical application globally, even in its birthplace China.
The reason for such sad reality was complicated in both of practice and ideology.
Firstly,
is the hindering of interest groups for commercial interest
In history, there were times attempts in trying to cancel Chinese medicine, even if in China, some of they were launched by interest group, such as, drug makers in synthetic medicine from the concern of commercial competing, and the most of the attempts were launched by the people who were trained in Western medicine with eyes that look down on Chinese medicine, until to today, never stop.
It is no doubt, for the application of OTC Chinese medicine in Canada, the big resistance will be from the drug makers. As a solution, we may provide them business opportunity in the production of natural pharmaceuticals.
Secondly,
is that research activities are for academic not clinic
The main body of modern studies on natural Chinese medicine was in the academic circle, in the universities, in the institutes; it was driven by the need of professors for teaching tasks, the need of students for gaining their degree in Masters or PhDs, especially the need of the funds for scientific research.
In fact, all of such activities were driven as career in living making for survival, and such related.
Speaking to here, you would agree my judgment:
the majority of human activities were driven by the purpose of survival. If we
view the reality in this way, many thorny problems that entangled and
complicated by confused ideology may be easily understood, especially in this
topic.
Thirdly,
is that research results on animal dare not use on human
In the research process, the most used experiment object was rats, not human patients, so the results cannot be directly used clinically. Moreover, after the studies were published, they also were mainly circulated and used in academia, rare of them entering the application in clinical circle – they were seldom used to solve the problems in disease treatment.
Fourthly,
is that legal risks restrained clinicians in use of Chinese medicine
In general, the clinicians in Western medicine were not interested for Chinese medicine with inherent beliefs that TCM is not scientific. The clinicians in Chinese medicine were not interested for the results of modern bio-pharmaceutical studies also with indulged in well-known experiences to cook soup by raw Herbal Pieces.
In the clinical practice; the both of them were firstly concerning self-protection to avoid being litigated and confidently treat patients according to their own experience or legally approved medications due to that clinical treatment involves life-saving, even if they understood the cured rate of they used medications were low with obvious negative effect.
For sure safe, even if they knew that Chinese medicine was effective, but, they never directly apply to their own patients with the fear of taking responsibility for possible unexpected medical accident that may cause legal proceedings; though, even if, FDA, EU and Canada have issued laws to treat natural Chinese medicine as OTC in the name of supplements or food additives.
Since such reasons, the unbelievable absurd phenomenon was in popular, which was that the research belongs to the research, clinic belongs to the clinic, and they were going on their own way in following the parallel direction; as that of the water in the well was rarely able to mix with the water in the Mainstream River, even if, the water from the well was more healthy.
Fifthly, is the improper approval process for marketing
Under the misleading of philosophy – reductionism, in the process of approval for marketing, treats natural Chinese medicine by the way as that of treating synthetic one with cost of long time and spending, which acted as shackles in hindering the popularization of the use of natural Chinese medicine.
Since the placebo effect was clinically proved in last century, many synthetic drugs have been found to be less clinical effective than that of placebo, but have lethal side effects. Therefore, the FDA required that the clinical use of the synthetic drugs must be supported by clinically double-blind with the proof of effective than that of the placebos.
Due to that all of Chinese medicines were in compound component with complex of bioactive composition, even if a single herb is also with complex components, so that it is difficult in making clear that which kind of constituent has played which kind of therapeutic role, it is almost impossible, which cannot get the results to meet the requirements of Western medicine for clinical trials – the clinical role of each component has to be made clear.
Though the request of clinically double-blind was rational scientifically, but, it also caused the high cost in both of funds and time for the new combo of natural Chinese medicine going into the application clinically.
Sixthly, is that TCM is too difficult to be understand
The most theories of TCM were written in ancient style of Chinese with difficult in understanding for modern people, which caused by the limitation in the number of the development of Mandarin characters in ancient time, the text in ancient style is difficult to be understood for nowadays people.
Seventhly, is indulging in old culture and rejecting new things
Even in China, the home of birthplace of TCM, the doctors and officials in Chinese medicine have indulged in the theories of classical Chinese medicine, with believing that is necessary for protecting cultural heritage; they are difficult to accept the results of modern pharmacological researches on Chinese medicine, even with somewhat rebellious mentality, which proved by the reality that in the overseas market of Chinese medicine, China has only 0.3% of patent rights, while Japan and South Korea occupy more than 70%.
Eighthly, is from people’s stubborn superstitious thinking
People are used to old-fashioned conservative habit under superstitious thinking by misunderstanding on scientific. There replies followed my comment was a good example for understanding the ideological resistance.
Mar. 5, 2018, on facebook, there was an article UW student dies by suicide at student residence reported that a student of University of Waterloo died by suicide when he jumped from a 12th floor student residence building. Follow was my comment and the replies followed my comment.
Frank Li: Chinese medicine can reduce the suicide of sufferer with depression.
Rich Reist: Any type of therapy can help but science based medications are more reliable than untested herbs and that sort of thing.
Also there was rational reply.
Lara Kristina: Rich Reist many "science based" antidepressants actually cause suicidal thoughts. They are a huge part of a very complex problem.
From the dialogue above, we can understand that people’s superstition in science is ingrained and difficult to remove. Most people cannot understand that only practical results can prove the good or bad of the things, rather than the dogma.
Ninthly, is that ignoramus dogmatists are always in dominating
Maybe, it was distressed feeling from such confusion and frustration, years ago I once wrote article To Make Possible from Impossible by Breaking the Shackles of Dogmatic, in which I shared similar distressed feeling of John Maynard Keynes in his article The end of laissez-faire 1926.
“The compelling force of many of the original reasons has disappeared but, as usual, the vitality of the conclusions outlasts them.” “The average man averts his attention from the problem, and has no clear idea what he really thinks and feels about the whole confounded matter.” “Confusion of thought and feeling leads to confusion of speech.”
John Maynard Keynes was a British economist whose ideas in dominating modern economy as economic policies of all of governments except Germany, such as, monetary easing, 2% inflation, government investments and so on.
Today, here, you may agree that the progress of human civilization is the process of battle with ideological confusion, and it was the process of battle in between the knowledgeable pragmatist and ignoramus dogmatist. It is same in the population of TCM.
In my view, above nine problems were the main barriers in hindering the clinical application of natural Chinese medicine.
The solution for the problems depends on the liberation in the thoughts with the updating in the way of thinking.
The solution for the problems depends on the liberation in the thoughts with the updating in the way of thinking.
Luckily,
in Canada, beside the legislation in treat Chinese medicine as OTC as supplements,
the ordinary citizen are also gradually realized the therapeutic effects of
Chinese medicine and use it willingly in private expending. Such as, many
times, I want to buy some OTC tablets Chinese medicine in the pharmacy of
Chinese medicine Toronto, but, the answer was that the medicine has been bought
all by local white people.
In
China, the promotion of the use of natural Chinese medicine is going on a
rational way from the level of getting rid of dogma under the conduct of the
government.
Apr.
4, 2007, the International Journal of Science - Nature online published China
plans to modernize traditional medicine to have reported that, China has announced an ambitious
attempt to bring the ancient practice of traditional Chinese medicine (TCM)
into line with modern standards. The government says it will expand basic and
clinical research, and improve the testing and developing of TCM remedies for
export. The project is backed by 16 Chinese ministries, spearheaded by the
Ministry of Science and Technology, the Ministry of Health and the State
Administration of Traditional Chinese Medicine and earmarked $130 US million.
In October 2017, there was report that traditional
Chinese medicines may no longer be required to pass safety and efficacy trials
in humans clinically. The China Food and Drug Administration
(FDA) suggested traditional medicines can skip such costly and time-consuming
trials as long as
manufacturers prepare ingredients using essentially the same method as in
classic Chinese formulations. The FDA and the State Administration of
Traditional Chinese Medicine of China will compose a list of the approved
methods.
The
rational promotion with powerful Gov-leading and -funding will be largely promoting
the population of Chinese medicine.
In
addition, the practice of China’s government has big limitation with some kind
of irrational – “as long as manufacturers prepare ingredients using essentially
the same method as in classic Chinese formulations.”
In
fact, those “classic Chinese formulations” were not clear in bioactive ingredients,
especially in potential toxicity, though long use has proved they were
effective and safe. But, the right way, as my view, at least, they should be
combined by the review according to the results of modern studies on the bioactive
ingredients and their pharmacological effects, by which way updating classic
formulations, the therapeutic effect will be much powerful.
Here, as a proof, I have to point out that, the combo OTC
tablets Chinese medicine that I used to have cured a young man of 10 years in psychotic,
was not according to any “classic Chinese formulations”, but, according to the
physical condition of the psychotic young man, from the comprehensive physical adjustment
– basic metabolism, digestion, nutrition, sleep, immune, blood quality, vascular
health, and so on, especially, improve blood circulation with broken the
blood-brain barrier.
My
treatment was focused on the restoration of the physical condition, thereby,
restores abnormal secretion of the chemical to normal, rather than as that of synthetic
antipsychotic drugs in Western Medicine was simply focusing on the inhibiting
of chemical secretion with dead side effects.
1. General Introduction
Traditional Chinese Medicine (TCM) is an accumulation of the experiences of medical practices in Far East China. Because it has initiated from primitive Era in thousands years ago, so there are no concepts and terms of modern anatomy and biology, its medical descriptions are using the terms and the principle of its philosophy - Daoism that is similar to the holism of western medicine. Therefore, for the people who were educated with modern science, it is difficult to understand and to have caused the sense of mystery even misunderstood as witch or sorcery.
Modern researches have unknowingly and indirectly proven that TCM is the best medical system world widely so far compared with that of existences, especially Western Medicine (WM).
This article is trying to use the
terms of WM to crack down the mystery through introducing the basic
principle of Daoism, therapeutic mechanism and the
modern researches of TCM. Thereby convince people to enjoy the ancient
civilization willingly. Thus, many incurable diseases will be curable and the
cost on the medications will lower down largely.
Although the social materials
wealth is increasing but the polarization between the rich and poor is increasing
too. There many people are struggling in the bottom of the modern society, hard
working every day but less ability to afford expensive medication,
well-equipped Hospitals are everywhere, but, they have no money to step in,
even no ability to enjoy the fruits of modern civilization they made. Although
the people do not have to worry about medical expenses in some rich welfare
countries, however, long time waiting for treatment has become a life threats.
The reality is urging us to serious consider the way out for dilemma in human
health care.
WM has been taking Reductionism as philosophical guidance,
it looks human body as an assembly of parts, and tries to study, diagnose and
treatment of the diseases through the isolated part by reducing human body as
micro as protein, gene and even peptides. Today we even can make life by
genetic technology in a tube. So public have been convinced that modern WM is
most advanced, most scientific and most reliable.
However, because human body is a
complex system that various organs are closely interconnected with
interdependent and interacting, there may be many unpredictable factors in
affecting the development of diseases, especially the psychological factors.
Many objective facts have proven that the medical route under the guidance of
Reductionism is not sustainable feasibly, for instance:
Nine years ago, we once cheered
for the completion of Human Genome Project with the happy of getting a
new powerful therapeutic approach. Many of us thought that we could uproot all
human diseases since then.
However, until now, it seems to
have no genetic therapies been applied in clinic safely and stably, because
there may be dozens even hundreds different gene-fragments in affecting the
development of one diseases. Therefore, those believed as most advanced, most
scientific, most reliable genetic therapies are only hopeful flowers that may
need long time, and more study to bear enjoyable fruits. I believed that, this
fruit can not mature forever, because it can not uproot the stress or
psychological pressure – the main inducement of the diseases.
On the other hand, there are no
suitable synthetic drugs for some diseases, such as, super bugs. Even those
existing drugs are not all safe; the side effects of some of them are becoming
new life-threats. More terrible is that the cost of medications is soaring up;
even some people take the medical activities as the tools to loot money in
contempt of life. It is just like the earthquake in Japan, coupled with the
Tsunami, which was not enough, followed by nuclear radiation.
It is very disappointed but is a
corollary under the misleading of Reductionism.
In as much Reductionism cannot
work well, we should introduce new philosophy into medical system. The hopeful
one is Holism – a philosophy that macro-views human body as whole, and
considers all the affecting factors, including psychology. However, “There Are
Two Sides to Everything.” Compared with Reductionism, Holism is too macro that
may induce to ignore the factors of micro. Therefore, the best way is to
combined use them to make up the disadvantages by the advantages of each
other’s, and avoid their disadvantages. Thereby we can get rid of the current
predicament in Western medicine. However, distant water cannot solve the
immediate thirsty. We need to find another way out.
There are many experience-based
therapies have been developed and accumulated in the populace’s daily life with
the advantages of effective, safe, cheaper, handy and easy to use. They are
good resources for developing alternative therapies. Among them, TCM is
outstanding.
TCM has been developing under the
guidance of Daoism - an ancient philosophy of China.
Daoism is contrary with Reductionism. It is similar with Holism and consistent with systems biology. Suppose that Reductionism
focuses on a specific grass on the Himalayas, and then the Daoism is not only
focusing on the entire grass, but also concerning those would affect the growth
of grass, such as, destructive pests, the greenhouse effect and the reduction
of glacier cover, etc.
Under the guidance of Daoism,
human life is being taken as one of such a component of unity of opposites. It
believes that human body is an organic whole that all components are closely
interacted. A well-balanced human
bodies will form an effective self-defence system that can handle the most of pathogenic
agents. The diseases could happen only if there are some unbalanced parts in a
human body. The treatments do not directly target to kill pathogenic but to
bring back the natural balance. It achieves the purpose by natural therapeutic
approaches, such as, natural drugs, acupuncture and physical exercises, etc.
Compared with Western medicine,
TCM was believed as most primitive, most unscientific, and most unreliable.
However, many modern researches have inadvertently proven the outstanding of
TCM. Its holistic perspective with emphasizing the decisive role of psychological
factors on the development of diseases is most rational and scientific. Such
as, Henry K. Beecher’s The Powerful Placebo (1955), George Engel’s Biopsychosocial model (1977), the crossing
disciplines research proved that Stress Causes
Everything (2008),
Ohio State University’s Socially active
environment can cause cancer tumors to shrink and even disappear (2010) and British Man with 'Locked-in'
syndrome makes amazing recovery by his will for survival (2010), etc. Those
findings clearly indicated that, for most diseases, negative psychological
plays inducement effect and positive psychological has therapeutic effect. On
this point, TCM is much admirable.In thousand years ago, TCM practitioners have found the similar fact
that diseases treatment is seven-tenths in psychotherapy and only three-tenths
in medication. Suppose we take theplacebo effect as a kind of psychotherapy,
then the proportion of seven-tenths in psychotherapy is close to the modern
scientific statistics from the double-blind clinical trials, which was “placebos are effective in 50 or 60
percent of subjects with certain conditions.” And “some researchers
maintain that
there is not adequate evidence from studies to prove that the new
(antipsychotic) drugs are more effective than placebos.”
The emergence of system biology is showing that Western
medicine is starting to step toward the Holistic way with enlarging the scope
of medical analysis. Essentially says, it was that Western medicine is from
philosophical root turning its heads toward the ancient holistic medical
approach of TCM after its hitting on the wall.
TCM has developed unique methods
in diseases diagnosis and treatment by natural ways, such as Pulse diagnosis,
Tongue diagnosis, Acupuncture, Massage, especially a large number choice of
natural drugs. According to the statistic of national investigation of mainland China in the
80's of 20th century, there are 11,146 plants, 1581 animals and 80 minerals as
medicinal using. The <Dictionary of Traditional Chinese
Medicine Prescription> selected nearly 100 thousands of
experience-based formulas from prescriptions of TCM since there are written
records in the history of China, which covering almost all known diseases.
Thanks the scientists of China, they have made many useful modern researches on
Chinese drugs by emulating the methods of western medicine, and to have had
those experience-based formulas updated and produced great many OCT drugs in
the forms of convenient for using. Such as, injections and sugar covered
tablets with the labels of providing treated-ranges, precautions and dosages.
The medicinal materials (natural
drugs) used in TCM are all from nature. Modern studies from the level of
molecular, protein and gene found those natural drugs containing a wide range
of bioactive constituents. Some of them have therapeutic effect that is similar
to that of synthetic ones in killing the pathogenic agents directly, and some
of them have nutritional effect that is similar to that of orthomolecular
medicine. For
ill-debilitated patients, nutrition is even more important than that of drugs.
I think that this is the unique advantages of natural drugs, and also it is the
unique advantages of TCM.
Modern researches revealed that
some of Chinese drugs can improve human immunity, such as, boosting the weight
gains of immune organs, increasing the number and activity of the phagocytes,
NK cells and so on. Therefore, in subjective viewing, TCM is to regulate the
physical balance, but in objective practicing, the process of the regulations
plays a role of improving the immune function, then the pathogenic agents to be
killed by enhanced immune system. Although, in TCM there are no concepts of
modern immunology, such as, immune organs or immune cells, the experience-based
formulas were never to have considered on immunity, however, some of
preparations by those formulas are playing the therapeutic role through
enhancing human immunity. More significant is that when the physical balance of
patient is restored, the most of uncomfortable symptoms of patient would be
largely improved, such as, poor appetite, angst and insomnia, patient would
feel much better not only in physical but also in psychological. Indeed, the
physical improvement also plays the role of psychotherapy. The recovery of the
diseases can certainly be accelerated.
The compound prescription is
unique therapeutic method of TCM, which is to put many different natural drugs
together as one dose. Studies have proved that drugs in compound using are able
to generate synergy effect of multiplying the positive effect of each other.
The findings revealed the mystery that preparations by experience-based
formulas of TCM are more effective on some specific diseases and provided clear
guidance for selecting effective natural drugs aiming on specific pathogenic.
This is the reason that, in my hand, Chinese natural drugs seem to have gained
magic in treating some thorny diseases, such as, Schizophrenia, fat liquefaction of
incision and
so on. Chinese drugs will be a powerful therapeutic approach on the diseases
both communicable and non-communicable, which not satisfied by the treatment of
synthetic drugs. Clearly, Chinese medicine is promising resource in developing
new therapeutic approaches both drugs and therapies. Also it has huge market
potential.
However, since that TCM is
accumulation of the experiences from medical practices started in thousands
years ago, there are no concepts and terms of modern anatomy and biology. The
medical descriptions of TCM are using the terms and the principle of its
philosophy - Daoism, such as, Yin & Yang, and cold & Hot. The diagnosis and the treatment
of diseases are from this philosophical perspective to regulate the balance of
the unity of opposites. It is very different with that of Western Medicine (WM)
that is only focusing on the specific ill organ or pathogenic. As the same way,
Chinese drugs are sorted and used to restore the physical balance of human body
rather than focusing on any ill organ or pathogenic. Therefore, it can not be
easily understood according to the way of WM.
Due to there is no corresponding
English words; it is difficult to directly translate TCM into English in
accordance with its original meaning accurately. In addition, TCM are based on
great many written records from different historical period spanning thousands
of years, many of those records wrote in Classical Chinese even in Oracle bone script, which is similar to that of
some thing written in Old English, they are not easy to be
understood. So that the unique philosophy and therapeutic efficacy of TCM was
not be well understood & applied as it should be.
Even so, I firmly believed that,
with my articles of <Viewing Human Life as Emotional Alive> together, the
medical vision of readers would unconsciously advance into a broader Holistic
scope from that of Reductionism. The advancement of the philosophical approach
would release huge medical potential that can help us to learn properly about
our life physically and psychologically, thereby to help more people living
healthier and happier by advancing the prevention and treatment of the
diseases.
The holistic view on human life
mainly embodied following areas:
Human beings self, people and
people, people and society, and people and nature is all in the state of unity
of opposites. They must maintain in harmonious balance, once occurs deviation,
people would fall into ill, between the people would conflict, the human
society would fall into disorder and the nature would punish humankind. Those
thoughts play a directing role in the diseases treatment.
1. Emphasis on the restoration of
physical balance
TCM believes that human body is
an organic whole that all components are closely interacted.A well-balanced human
bodies will form an effective self-defence system that can handle the most of pathogenic
agents. The diseases could happen only if there are some unbalanced parts in a
human body. The treatments do not directly target to kill pathogenics but to
bring back the natural balance. It achieves the purpose by natural therapeutic
approaches, such as, natural drugs, acupuncture and physical exercises, etc.
Jan. 12 2011, a report that H1N1 and other
seasonal influenza swept France and caused many deaths. According to the
experiences of China, if the treatment integrates with some Chinese drugs to
improve suffered symptoms of the patient holistically, the patients who fall
into critical would be largely reduced. There is a simple method for rescuing
critical patients. I will introduce it later.
Talking about the restoration of
physical balance, we must make clear the physiological effect of nutritional
ingredients in Chinese drugs.
A good example is Orthomolecular
medicine (OM).
It was coined by Linus Paulin who was enlightened from the successful
practice of Canadian doctors who cured mental illness
by megadose Vitamin B3 after read the paper of <The Vitamin B-3
Therapy: A Promising Treatment for Schizophrenia – and its high relevance to
the field of alcoholism> that wrote by Bill Wilson, in
December 1965, that was A communication to A.A.’s Physicians, not for public
quotation or use.
The copy was from:
Centre for Addiction and Mental
Health, CAMH
Library
33 Russell Street, 2nd floor, Toronto,ON,M5S 2S1
Information Desk: 416.535.8501
x6988
The cover is as follow. (A.A. - Alcoholics Anonymous).
The OM was originally intended to
treat the “mental disease by the provision of the optimal molecular environment
of the mind, especially the optimal concentrations of substances normally
present in the human body.” OM currently is called as diet supplements that
have developed many products, such as, Vitamins, minerals and so on.
Linus Paulin who published the <Nature of the chemical
bond> in
1939. Later he did many pioneering works in understanding the nature of life
from atomic structure, binding mode between atoms, nucleic acids and proteins.
Whether from chemical, biological, and medical, he has laid a solid theoretical
foundation.
Vitamin B-3 has wide range of
physiological improvement functions. Its therapeutic process for psychotic is
to restore damaged brain rather than as that of antipsychotic drugs control the
abnormal secretions in the brain. Naturally, OM treats the diseases in a
Holistic way.
Although, for decades, some
people have been eagerly trying to deny the curative effect of OM, however, the
physiological improvement function is coming clearer in both clinic and
academic. Now it gains extensively application world widely. Vitamin C was the
one of OM, which was Linus Pauling strongly recommended, also was strongly
opposed by others. following are some of new researches on Vitamin C.
1. <Vitamin C Saves Lives!> After Linus Pauling wrote
his book on vitamin C in 1970, mortality from heart disease decreased 30-40% in
the USA. From around 741,000 deaths per year to less than 500,000 deaths by
1986 - U. S. Bureau of National Health Statistics 1986.
2. <Vitamin C may be
useful to treat cancer after all>.
3. <Study shows vitamin
C's cancer-fighting properties>.
4. <Vitamin C beneficial
in cancer treatment – study>.
5. <How Vitamin C Stops
Cancer>.
In TCM, there are variety of
nutritional constituents that are far more than that of in OM, which come from
more than 10 thousands of plants, minerals and animals, such as, Ginseng,
Gypsum and Placenta. They are certainly playing a significant role in the
diseases treatment, but their unique contribution seems to have been ignored
both clinically and academically. The reason may come from the TCM itself
because that it never distinguishes the medicinal and nutritional, even without
the concepts and terms, they were generally called as medicine. In western
medicine, Chinese medicine generally called as alternative or diet supplements.
I think that there is necessary to make a definition, such as, those with the
effect of killing pathogenic agents should be called as medicinal, and those
without the effect of killing pathogenic directly but with the role of
physiological improvement should be called as nutritional, include those in
Western medicine. A clear concept with a exact term will not only help clear
describing, but also conducive to efficient thinking. The determination of a
definition is difficult that need to be discussed carefully because of the
ingredient of many single herbs is compound that contains both medicinal and
nutritional. Even if a single constituent also has a dual role, such as, some
peptide is nutritional but also an antibiotic. The nutritionals in Chinese
drugs is a promising medical potential to be an attractive research direction.
Acupuncture is a treatment method
based on Meridian. Modern researches showed that
it could stimulate the blood circulation in some certain area of body by
acupuncture on some specific acupoints to achieve the therapeutic effect.
Clinical practices show it work well on many diseases, such as, stroke, pain, etc.
There are many physical exercises
methods in TCM for enhancing physical strength. TheTaijiquan (Tai Chi Quan) is the one of them. Researches
show that it can improve human immune function and treatment of many diseases.
See articles: Benefits of Taijiquan
Strongly Supported by Science. Comprehensive therapeutic benefits of
Taiji: a critical review.
2. Emphasis on therapeutic effect
of psychological factor
Modern researches have proven
that human psychology acts as a double-edged sword that positive side can
promote health with curative effect; negative side can damage the health with
pathogenic effect. TCM has found the same fact in thousands years ago, and has
indicated that the process of the disease treatment is seven-tenths in
psychotherapy, only three-tenths in medication.
Such as, Henry K. Beecher’s The Powerful Placebo (1955), George Engel’s Biopsychosocial model (1977), the crossing
disciplines research that Stress Causes
Everything (2008),
Ohio State University’s Socially active
environment can cause cancer tumors to shrink and even disappear (2010) and British Man with 'Locked-in'
syndrome makes amazing recovery by his will for life (2010), etc.
1955, H. K. Beecher published
<The Powerful Placebo>." He indicated that there 35% of 1,082
patients were satisfactorily relieved by a placebo alone. “Other studies have since calculated the
placebo effect as being even greater than Beecher claimed. For example, studies
have shown that placebos are effective in 50 or 60 percent of subjects with certain conditions. It
is close to that estimation of seven-tenths in psychotherapy of TCM.
1977, George Engel coined Biopsychosocial model: “a general model or
approach that posits that biological, psychological (which entails thoughts,
emotions, and behaviors), and social factors, all play a significant role in
human functioning in the context of disease or illness. Indeed, health is best
understood in terms of a combination of biological, psychological, and social
factors rather than purely in biological terms.”
2008, a report that a research
crossing the disciplines of psychology, medicine, neuroscience, and genetics
revealed that “stress causes
deterioration in everything from your gums to yourheart and can make you more
susceptible to everything from the common cold to cancer.” The results mean
that psychology plays a decisive role in diseases inducement.
2010, the scientists in Ohio State
University published <socially active
environment can cause cancer tumors to shrink and even disappear>.They found that there were 5%
cancer-infected mice’s tumors disappeared and 77% of them decreased the tumors’ volume by
43% only from living in an socially active environment for 3 weeks.
2010, a report that Mr.Graham who once paralyzed with Locked-in syndrome and
medical staff have left him to die, but he never gave up the desire for life
and firstly tried to move his toe by will and succeed in months later, then to
move the finger and then he has stood up again. Actually, it was that the
positive psychology cured the disease of Western medicine believed incurable.
If the idea of seven-tenths in
psychotherapy and three-tenths in medication can be universalized the diagnosis
and treatment of human diseases can be humanized greatly. More pleasant is that
the positive psychology can create by the positive activities of social and
physical. No doubt, it is a feasible self-help therapeutic approach with
broad-spectrum feature. It is a true panacea that can be produced when we
enjoying the life. It may be an only fair thing in the world, which can be
shared by all people, no matter who is poor or rich, old or young.
In China, some doctors will use
ingenious methods to adjust the patient's psychological state. For example, for
those patients who diagnosed as serious diseases, they would not tell the truth
to patient, but tell their families, thereby to avoid the psychological burden
for patients. However, in the eyes of Western doctors, this thoughtful manner
is cheating and immoral.
Chinese drugs can improve overall
physical strength of patients through improving appetite, sleep, and many other
uncomfortable conditions, so that the psychological state of patient will be
improved largely from the physiological root.
3.Emphasis on the disease
prevention
Huang Di Nei Jing a most important medical
book of TCM in two thousands years ago said that the highly skilled doctor
treats the diseases before its outbreak and indicated that medication after
disease’s outbreak is similar to dig the well when felt thirsty and to forge
the sword when the fighting has started, it is too late. This means that we should
rather focus on the diseases’ prevention than focus on the treatment. The idea
has a practical significance in modern society.
TCM has developed many physical
exercise methods for diseases prevention and treatment. Such as, Taijiquan
(Tai Chi Quan) mentioned above.
Above are only rough examples.
The Holistic view on human life in TCM is much comprehensive not only above
three points. I raised them here are intended to arouse public boldly to find
more effective natural therapeutic ways, just as that of ancient people of
China.
Although, the trend of medical
philosophical approach toward Holistic has been emerging in western medical
field, such as, the development of system biology, FDA has accepted the idea of
traditional Chinese medicine idea.[1] [2] in their drugs regulations,
and some super drug makers have dug into CM. However, there are much
improvement room for comprehending and applying the Holistic therapeutic
principle of TCM,
In the current process of study
and application of TCM, people are still trying to find the bioactive
ingredients and apply them in single constituent to treat diseases clinically
as doing with that of synthetic drugs. Essentially speaking, it is not get rid
of the leash of Reductionism.
No doubt, that treat the diseases
in purified constituent is a great progress by promoting the use of the natural
medicinals accurately and safely. However, if the bio-active constituents are
not being used in compound, it will lose the synergy effect, the therapeutic efficacy would
be largely reduced. More worse is that may lose the advantage of eliminating
the drugs’ negative effect from/by each other, there may be some side effects
occurred as same as that of synthetic one. Such as, Tamiflu is extracted from star anise – a
pure Chinese herb. It has showed serious
inverse effect clinically.
By emulating the methods of
Western medicine, scientists of China has done a lot of researches on Chinese
drugs, and achieved many promising results. Although the most of individual
study is one-sided, but when string those research results together, we would
pleasantly find that the medicinal constituent, nutritional constituent and therapeutic
effects of natural drugs are so extensive and effective. Even some single
natural drug has broad spectrum of pharmacological effects because it is a
compound of medicinal and nutritional. Later, you will share my feelings.
Evidence-based
medicine (EBM)
is a new trend developed in recent years. It “aims to apply the best
available evidence gained from the scientific method to clinical decision making.” Some people say that experience-based
medicine changes to the EBM are a profound revolution in clinical medicine of
twenty-first century, and will be an inevitable trend. Those medical researches
under the guidance of Reductionism, cells, proteins, genes and double-blind
clinical trials, have made many people believes that kind of researches are
real scientific and pure science, so the research results are reliable without
any reason to doubt. Driven by this kind of superstitions, some people have
begun to question the correctness of TCM, and said it is an experience-based
medicine to have outdated, even there were people repeated the same old tune of
appealing to abandon it in China recently.
In fact, TCM does not come from
the magic fantasy. besides its medical description with the terms and principle
of its Philosophy - Daoism, which are not easier to be
understood; many of other parts are from a lot of therapeutic experiences of
trial and error in long time massive clinical practice, which are similar to
that of Western medicine from scientific studies experimentally. Some of the
therapeutic experiences of TCM are reasonable and some may be not, which is
similar to that of some synthetic drugs are effective and some killed people
although they were all proven safe by so called scientific experiments and
supported by the scientific data from strict double-blind clinical trial. More
important is that those drugs are all to have approved by FDA. No one doubts
that FDA is one of the most trusted authorities on the drug’s regulations. Its
effective work has created a safer medical environment and increased the
confidence of people on medicines. However, in view of some of their approved
drugs have still killed people, we have reason to question that, are the FDA
dereliction of duty or is medical philosophy improper to have lead the problem
in medical methods?
Three-tenths in medication and
seven-tenths in psychotherapy were simply estimated result according to the
personal experience of ancient doctors of China. However, it is close to that
of the scientific data from modern clinical practices. Modern scientific
researches proved that those natural medicinal materials of TCM were sorted
obvious scientific by unscientific primitive methods of seeing the color,
smelling the smell, tonguing the tastes and clinical trials. For example, those
were sorted as enhancing digestion are rich in Ca, Zn and Fe. Those were sorted
as enhancing male sexual ability are rich in Mn and Cu. The therapeutic
experiences got by primitive tools and methods under the guidance of the right
philosophy are not worse, even better than that of got by expensive and
sophisticated modern equipments with being considered as most scientific
methods. The development of Medicine is for saving life, effective one is
scientific and ineffective one is not scientific, no matter how it is made. We
need to consider seriously that what the scientific is and what it is for.
Scientific has been using by some
self-crowned master as a label to mark some thing correct or not. TCM is one of
the victims. I think that, human civilization has evolved into today, even
consumes whole lifetime, there is no one could learn through any discipline, I
mean to make it clear entirely. No one could have enough knowledge to be a
master or authority for declaring to abandon any fruit of human civilization,
although in today's perspective, many of them may be not perfect.
There are two sides to
everything. We must
look at anything dialectically and practically to avoid going into a dogmatic
dead end. We should not completely abandon the experience-based medicine when
promote the evidence-based medicine, and vice versa. We should reserve the
reasonable portion from every thing and use them integrated.
I must special point out that,
due to the difference of physical and diet, when using the same natural drug,
the physiological reactions may be different from people to people, especially
for those who are in different ethnic groups or in different region. For some
people are effective; some may be ineffective or even have side effects. We
should pay serious attention before use them and study on it. It is better to
increase the dose gradually to reach the level that recommended. Generally say
that some of natural drugs have side effect, but it is much minor then that of
synthetic ones or caused by improper use only.
There are reports that some
Chinese drugs contain heavy metals and pesticide residues. I think that
compared with no drugs to use, the metals and pesticide may be not a serious
concern, so that those drugs with problems should not be forbidden but give warning,
use or not, leave the choice to patients.
For a long times, WM have been
playing an important role in the prevention and treatment of diseases world
widely. It qualified to be called as mainstream medicine. However, now it is
unable to extricate itself from trouble quagmire.
Such as, for the infectious
diseases, it has failed in updating the antibiotics due to that fast mutation
of super bugs has shortened the effective
life of antibiotics and caused increasingly high research spending. Now
some drug-makers abandoned
their research into antibiotics. For the non-communicable diseases, it is much
disappointed since no satisfied drugs, too.
On other hand, the inverse
effects of synthetic drugs have become the life fatal threat. Such as, Britain
has issued a warning on more than 60 cough and cold
medicines that
can not be given to children after causing dozens of deaths. There was a report
that Newer Antipsychotics
Have Same Increased Risk of Sudden Cardiac Death as Older Ones. The drugs were developed for
saving life rather than to kill life, however, as same as a lot of other things
in the actual world, they are deviating from the will of kind-hearted people
and are going farther.
Recent years, the system biology has been developed. It
eliminated the deficiency of Holismand Reductionism by making up the gap
between them. I called them as three medical philosophical brothers. Only the
three works together, we can properly understand our body and the nature of
development and recovery of the diseases. They have paved a new Medical
Boulevard by forming an integrated medical philosophical system.
Here, I would like to make clear
that, I promote the Holistic medical approach is intended to improve the
balance of Philosophical approaches of Medicine by promoting the reasonable
share that Holistic should take rather than to shoot Reductionism to die. When
we are continuing to search human beings deepen into the microscopic, also we
should take into account the macroscopic equally to understand human life
comprehensively on physical, psychological and social. The thinges will develop
in the opposite direction when they become extreme. It is not sensible that
focuses on either extremely. I prefer the dialectical thought of Daoism in
maintaining the balance between Yin and Yang universally. It has the
value far beyond the medical issue. If it can be universalized, the world would
have developed according to the will of kind-hearted people; there are more
harmony and lesser conflict. It will never be worse like today, even the
essential daily safe for life has been destroyed. The ghost of the barbaric
killers of Colonial expansion era is still wandering with a new deceive cloak;
the world will never have peace.
Because that deadly side effect
of WM, more and more people are looking for the hope from alternative
medicines. Among the existing alternatives, Chinese Medicine (CM) is receiving
increasing attention and welcomed world widely. Now it is becoming the hope in
helping us to get out of the dilemma in health care. The door is opened widely
for CM.
There were cases that are worth
to mention here for demonstrating the magical therapeutic effect of CM.
A 36 years old male psychotic who
was more than 10 years maintained by 20 mg Zyprexa daily
after first time onset and cured quickly at his 16, did nothing besides eating
and sleeping emotionlessly. It was that my preparation of Chinese drugs called
back his emotion in days – talkative, listening music, curious-asking and
willingly doing house works. He was sent to English language school after
months due to his parents were bored by his endless curious-asking. Then he
went to school everyday willingly alone, and he seemed to have restored the
memory of his previously learned English because of his study progress showed
as jumping. The result surprised me very much, although I believed some of
Chinese drugs in compound-use can work on psychotic, but I never expected that
it took effect so quick. I’ll discuss the case detailed in another article.
Other one was happened on my
younger brother who hipbone fractured in a car accident 10 years ago. After one
week of operation there was still 50 mm unhealed on incision suture and happened
fat liquefaction. Besides the replacement of medical gauze and adjustment of
the intravenous antibiotics conventionally, the doctors could not give more
help. I worried about the wound infection or necrosis, so I hammered some dried
raw herbs into coarse powder, then sprinkling on the watering area without
sterilization. After 3 hours when I curiously opened the gauze found that the
unhealed incision has crusted entirely. The appearance showed that the crust
formed much earlier than 3 hours. Now more than 10 years has past without any
sequel. The only logical explanation for fast heeling is that Chinese drugs
have updated the recognized wounds
healing process.
The successful cases made me
deeply believe the magic effect of CM and gave me a strong confidence to help
more people to enjoy the medical fruit from the ancient oriental civilization
according to my more then 3 decades studies and experiences of successful cases
with selected and self-designed prescriptions of CM.
I would like to make some
apologies here: 1. For those possible mistakes in the article. Because of my
literary culture both mandarin and English is too poor to convey the original
meaning properly. 2, For those lost the links of tracking original resources
cited in my article. I am no mean to prettify myself by stealing the works of
others. I only did some sorting works to make existing medical literatures to
be easier enjoyable. I would like to salute to those researchers for their
excellent works, no matter their work cited or not in my paper, no matter which
country they came from. Thank you for your hard working and great contribution
to the advances of human civilization.
2.1. Philosophy: The philosophical
approach of WM is the Reductionism that aims to reduce a
complex whole to the effects of one part (or parts) upon another part (or
parts), which
microscopically viewing a complex system is nothing but the sum of
its parts, and try
to understand the whole by studying the part. Reductionism contrasts with
the holism.
2.2. Achievement of WM: No doubt,
for a long time, the WM has been playing a dominant role in the treatment of
diseases worldwide. Due to its therapeutic advantage and the reasons for market
competition (See The Truth About The
Rockefeller Drug Empire), in China, there were attempts to abolish TCM and
promote WM instead. Even same events
occurred in Japan. however, recently Japan has redressed their positive
attitude and develop many drugs on TCM.
2.3. Human Genome atlas: In 2003,
the Human Genome
atlas was
completed. It is a big success of WM. Many people think that we have gotten a
new powerful approach to diagnose and cure diseases. Nevertheless, now 7 years
have been passed, there are lesser genetic therapy can be reliably used
clinically than that of ever hot expected. Because that even a single disease
is associated with hundreds genome segments, so it is very difficult to be used
clinically in a short time.
Plight of WM:
Communicable diseases: Recent
years, some pathogenic-bacteria were named as super-bug because they can
develop resistance to the existing class of antibiotics in short time after
drugs putting in use. New antibiotic research is facing challenging in the
competing against the mutation of virus. More time and spending are needed for
antibiotic updating. So that many super drug-makers have
abandoned the research in antibiotics. Simultaneity some drugs waswithdrawn from market because
of serious negative
effect. It will
cause no effective antibiotics to fight with infectious diseases.
Such as: In the United States, deadly
mystery superbugs kills soldiers and causes to amputate limbs among troops
wounded in Iraq, because no antibiotics were effective for the infections, even for
a slight wound.
David Picard, CEO and the
co-founder of Moleac, a biopharmaceutical company based in
Singapore, in his article THE RISE of
Traditional Chinese Medicine, said that “Western pharmaceutical
companies now spend over US$800 million on average to get a new drug
approved.”
“This cost includes the lengthy
and complex clinical development process which sees many potential drugs fall
by the wayside, either because they do not work or because they cause
unacceptable side effects.”
“Only around one in 17 candidate
drugs identified make it to market.”
“If the drug being researched
fails in the development process the losses can be considerable.”
“Pfizer, for example, recently
wrote off around US$1 billion and 15 years of research and development after
its experimental cholesterol drug failed to make the cut.”
“The industry is under increased
pressure to develop new blockbuster drugs as patents expire, and to cut
innovation costs. “
Non-communicable diseases: Also
became increasingly severe due to have no ideal drugs. Such as mental disorder,
cancer, hypertension, obesity, diabetes, cardiovascular disease, chronic
fatigue syndrome, and so on.
As a way in no way, in Sep. 13,
2007, Canadian Cancer Society and the National Cancer Institute of Canada has
launched a large, multi-year international study to try to find a way to help
the hundreds of thousands of men diagnosed with prostate cancer every year,
decide whether to opt for potentially life-altering treatments or choose
a watch-and-wait
approach. They
hoped that Surveillance Therapy against radical treatment would resolve one of
the thorniest dilemmas in prostate cancer care. Because of current therapy of
chemo and radiation will cause the cancer degenerated
faster.
28 February 2008, Helene Guldberg
published the Heart disease: we need
medicine not moralism. Said that “My mother died from a massive heart
attack several months after being put on a waiting list for heart surgery. If
she had been given the treatment she needed earlier she may still have been
alive today.” She appealed “the experts should be concerned. They should be
continually trying to reduce deaths from heart disease. Clearly, a hell of lot
more can be done to improve medical intervention”.
Indeed, for her mother’s heart
diseases, it was not that had no drugs, it was because that the synthetic drugs
could not be used for a longer-time due to the deadly side effects. I believed,
suppose that her mother had treated with Chinese drugs, they would be still
enjoying their colorful life together.
The cause of the plight: It was
induced mainly from the philosophical approach, the Reductionism. Because human
body is a complex system with psychological activity, there are many factors
that interacts the pathogenic and development of the diseases, especially the
psychological factors play a significant role. On the other hand, the most of
diseases are syndrome with many sub-symptoms; it requires that treatment focus
on the multiple targets with the well consideration of the interaction of all
the factors physically and psychologically. Nevertheless, the WM has ignored
those important factors. Therefore, it was that improper philosophical approach
caused it into a dilemma.
We should review our Medical
philosophy because of that philosophical approach is the foundation for doing
any thing correctly.
System biology: Recent
years, systems biology was developed. It is from
system-level to understand human health and diseases in organs, organism and
community. It is consistent to the Holism to understand complex biological systems in
their entirety. This effort has great potential for the advancement of medicine
with major implications for the future medicine and have emerged some pleasant
results already.
Anti-diseases by immunity: Cationic antimicrobial
peptides were
developed in Centre for Microbial Diseases and Immunity Research, University of
British Columbia, Vancouver, Canada.
“Hancock, who co-founded a
company to commercialize IDR-1, a 13-amino-acid peptide, says the peptide does
not kill bacteria directly. Instead it seems to prime the body's quick
and dirty immune response, called innate immunity. A subsequent infection,
he says, may then flag the body to send a surplus of white blood cells called
monocytes and macrophages to gobble up invading pathogens.”
3.1 Traditional Chinese Medicine
3.1.1. The origin of TCM, MCM and CM:
According to the developing model
historically, Chinese medicine should divide into Traditional Chinese Medicine
(TCM) and Modern Chinese Medicine (MCM). TCM was officially
defined by the government of P.R. China in the 1950's after undertook an effort to
coalesce many diverse forms of Chinese medicine into a unified system. It had no concept of modern
anatomy and biology. The MCM is that new research results on TCM by the methods
of integrating with Western medicine. The TCM & MCM should be integrated as
Chinese medicine (CM). All the terms include diagnoses, treatment methods and
medicinal materials, etc.
3.1.1.1. Definition of medicinal
materials: For the medicinal materials are being used in CM or TCM, have
different terms been used currently besides CM and TCM, such as, Chinese herbal
medicine. Since that besides botanicals, there are animals and minerals are
being used as drugs, too. So that Chinese herbal medicine can not exactly
represent the entire medicinal materials. In order to avoid confusion, it is
better to make some definitions. That all the medicinal materials are being
used in CM or TCM is represented by Chinese drug (CD). By the same way, Western
drug (WD) is used to represent the medicinal materials being used in WM.
There are many TCM terms are no
corresponding English word, so it has caused some translations unreadable. I'll
try to use simpler English words and cited some writings of others to make it
easier to be understood. Here I only clarify the Yin and Yang.
3.1.1.2. Yin and Yang are the
phonetic symbols of Mandarin. Roughly says that Yin means
dark and Yang means light. Mandarin was officially designed by P.R. China in
1950s. It provided a unified language with spell and pronunciation for the
people in 56 races of about 200 local languages throughout of China now is
promoting world widely.
The Philosophy of TCM is based on Daoism that is similar to Holism. It is one of the
important ancient philosophies of China, which has been deeply influencing
China and East and South Asia.
The core of the Daoism is Dao. “It refers to a power
that envelopes, surrounds and flows through all things, living and non-living.
The Dao regulates natural processes and nourishes balance in the universe.” It
dialectically views that everything is in the unity of opposites universally.
It embodies the harmony of the opposites.
Dao is symbolized by the Tai-Ji Diagram in which the Yin and Yang were coined to represent the two
opposites.
Tai Ji Yin-Yang Diagram
In Tai Ji Yin-Yang Diagram, the outermost circle
is called as Taiji or Wuji, which indicates that every thing universally is metaplasia from vitality
and movement in cycling endlessly. The black fish
represents the Yin, but its eyes are white that means yang, white fish
represents Yang, but its eyes are black that means Yin. The whole symbol means that
Yin doesn't leave Yang, and Yang doesn't leave Yin. They are opposites of each
other with contradiction and reunification. Each is understood to be an
integral part of the others. If one grows bigger,
other one will be smaller. The main task of Dao is to make Yin and Yang keep
in the state of harmonious balance.
Daoism views the universe as a system of the unity
of opposites(Yin and Yang)dialectically, which is composed
of many components - subsystem with own feature of unity of opposites. The
components are all in the state of dynamic balance through continuous
self-regulation. This primitive philosophical view generated thousands of years
ago is well coinciding with the modern science. For example:
In micro perspective, as small as
atom, extranuclear electrons cloud with the nucleus are both in the state of
attraction and repulsion, the electronics rotating around the nucleus in
dynamic equilibrium. They are in the state unity of opposites. Atoms are the
components to compose of natural materials.
In macro perspective, the planets
with the sun of solar system, and solar system with other galaxies are all
in the continuously rotating in the state of self-regulation by attraction and
repulsion of each other. They are also in the state of dynamic equilibrium of
unity of opposites.
Yin often represents
the negative, the female, dark, evil, cold, Earth, etc. Yang represents the
positive, the male, light, good, hot, Heaven, etc. “There would be no love
without hate, no light without dark, no male without female. When patients got
fever they would feel cold rather than hot.”
Daoism is contrary with Reductionism. It is similar with Holism and consistent with systems biology. Suppose that Reductionism
focuses on a specific grass on the Himalayas, and then the Daoism is not only
focusing on the entire grass, but also concerning those would affect the growth
of grass, such as, destructive pests, the greenhouse effect and the reduction
of glacier cover, etc.
In medical field, Daoism
macroscopically views the human body as a whole and considers the interactions
of various existing factors' from all components including the social and
psychological factors with an over thousands years’ belief that the therapy is
three-tenth in medication, seven-tenth in psychotherapy. The estimated
effective proportion of psychotherapy in thousands years ago is close to the
results of modern studies - “placebos are effective in 50 or 60
percent of subjects with certain conditions.”
TCM has developed an integrated
theory independently based on the profound culture background that developed
from thousands years China. It focuses on restoring the balance of human body
and fight against diseases by enhanced physical capacity.
TCM has been riddling thousands
natural medicinal materials through long time trial and error clinically, which
includes botanicals, animals and minerals. Modern biochemical and
pharmacological researches proved that Chinese medicine is sorted
scientifically according to the therapeutic effect. For example, those are
sorted as enhancing digestion are rich in Ca, Zn and Fe, and those as enhancing
male sexual ability are rich in Mn and Cu.
Meridian is a network system on human body found in
ancient China. It distributes throughout the body that connects specific part
from the body surface to the splanchnic organs. The acupuncture points locate
on the networks and it can induce therapeutic effect on specific surface parts
or splanchnic organs when stimulating them. Also some Chinese drugs can enrich
in specific parts to take the therapeutic effect in similar performance with
acupuncture.
3.1.3. The holistic view of life of TCM
It embodied that hunan body
itself, human and nature, human and society, human and spirit is all unified
whole and interacted each other.
TCM believes that human body is a
unified whole, which is composed of tissues and organs that performs different
functions, and they are organic links between each other. The components of
constitute the human body are indivisible in the morphological structure,
coordinated in the physiological function, interrelated in the metabolism and
mutually affected in the pathological changes.
Man and nature is a unified
whole. Human beings are the product of nature developed to a certain stage.
Nature exist the necessary condition for human survival. The motion and changes
of the natural world are bound to affect human.
People and society is a unified
whole, and many social factors may be directly or indirectly influence on human
psychology, physiology and pathology.
Human spirit and the body is a
unified whole. Mental activity is the advanced activities of human. Physical is
the foundation of spirit, and the spirit is the product of physical. In turn,
mental activity can significantly impact on the physical.
“TCM has a macro view
to most diseases: well-balanced human bodies can usually handle most everyday bacteria
and virus, which are ubiquitous and quickly changing; diseases happens only if
there are some unbalanced parts in a human body. Due to this macro philosophy,
TCM usually does not care what exact bacteria or virus are causing the
symptoms, but tries the best to find which parts of the body are unbalanced as
well as to find a strategy to bring back the balance. At the meantime, TCM
believes only symptoms matter because irregular symptoms from the human bodies
are the only faithful sources to deduce the unbalanced parts in a dynamic,
complex system like a human body. Consequently, the treatments in TCM do not
directly target to kill bacteria or virus but to bring back the balance of
human bodies. It is very surprising but understandable that a TCM doctor may
give very different herb prescriptions to patients affected by a same type of
bacteria, because the different symptoms from the patients indicate different
unbalanced parts in their bodies”.
Perhaps the biggest advantage of
TCM is its diagnosis. Many diseases diagnosed by TCM can not diagnose out by
WM. Many patients have felt significant discomfort, but the results of
pathological analysis of WM show no signs of any disease.
3.1.6. The difference of TCM
& WM:
In TCM the “Signs and symptoms are
the first clinical indication when treating human diseases. Elimination of
such signs and symptoms is the first priority in providing effective
treatments. Any biomedical measurements relating to any diseases must be
relevant to the signs and symptoms exhibited by any patient.”
“Western Medicine is
not a perfect medical system. Its significance lies on its pathogenic theories.
However, clinical signs and symptoms are only superficial phenomena, they do
not represent contemporary pathogenic theories.”
“In Chinese Medicine,
every diagnosis relies entirely on signs and symptoms. Differentiation of Hot
and Cold, Deficient and Excess is the crucial foundation in determining a
patient’s medical kilter. Eliminating such signs and symptoms is the ultimate
goal in Chinese Medicine. It also aims at improving the biomedical measurements
as indicated by pathogenic analysis.” – Commenter: youzhang@tpg.com.au
Western drug and Chinese drug has
different therapeutic mechanisms due to the difference of their philosophy.
Western drug's entity is manmade single constituent, take the single effect on
specific target. The allopathic is the main therapeutic mechanism. Chinese
drug's entity is a group of natural bioactive constituent, take the
multi-effect on multiple targets with the specificity. The physiological
regulatory is the main therapeutic mechanism.
3.1.7. Example of doctors’ work manner of TCM and
WM:
Now take a patient who is
suffering from stomach disease as example to show the different in their works.
TCM doctors would try to find the
causes by diagnosing the type of symptom. Does it induced by the improper diet
or psychological pressure or excessive physical exertion, and or seasonal
changes? Also patient has what kind of problems require to be adjusted? They
will eventually restore the overall balance?
WM doctors would try to find the
causes by the gastro-scope and biochemical examination to find disease area and
lesion extent as well as the source of pathogenic, such as helicobacter pylori.
Then try to restore the health by killing the pathogenic microbe with WM drugs.
However, now we have made clear
that some of digestion problems caused by psychological factors rather than the
pathogenic microbe. Such as irritable bowel syndrome, is lack of abnormalities
of morphological and biochemical, and closely related to the emotional changes
or psychological factors, in which case that WM drugs can not work.
Fortunately, TCM has been working well for either infectious or non-infectious
with very cheap natural preparations for a thousands years.
“"Traditional Chinese
medicine," sometimes shortened to TCM, involves the treatment of patients using the
fundamental approaches of healing developed over the last 4000 years in China.
The treatments in Chinese medicine include acupuncture, Chinese herbs, and Tui-Na,
which resembles massage therapy combined with therapeutic touch. Chinese
medicine has the longest history, and the most practical application, of any
system of medicine in the world, outdating Western medicine by about 3800
years. In China, doctors were practicing relatively advanced medicine before
the birth of Christ. Western medicine, in response, dismisses everything under
Chinese medicine, ignoring the long history of safe and effective use of
Chinese herbs, acupuncture, and other philosophies espoused by Traditional
Chinese Medicine.”
TCM emphasizes that cure diseases
before serious onset. This is one of its advantages. For the most of slight
illness was diagnosed by TCM doctor, could not be detected out by the doctors
or the means in WM.
TCM pays much attention on the
prevention of diseases, and developed comprehensive preventive measures, such
as, natural drugs, physical exercise methods, etc.
There is a research about the
effect of Tai Chi Chuan exercise on subgroup of T Lymphocyte and NK Cells. After 25 min exercise
performance in the group those have been exercising Tai Chi Chuan for many years, the
percentage of the CD3, CD4 cell increased, the ratio of CD4/CD8 increased and
the percentage of CD16 cells decreased. In quiet state, compared with that of
non-Tai Chi Chuan group, those in Tai Chi Chuan group, the percentage of CD3
and CD4 cells is higher; the percentage of CD8 cells is higher but without
statistical significance. So that Tai Chi Chuan exercise can enhance the
regulatory capacity of the cellular immune, and improve the body's cellular
immune function.
3.1.9. TCM & Psychology
3.1.9.1. Psychological &
diseases: December 1, 2004, CBC News reported Stress speeds up aging
of immune cells.
A study of crossing
the disciplines of psychology, medicine, neuroscience, and genetics reveals
that stress causes deterioration in everything from your gums to your heart
and can make you more susceptible to everything from the common cold to cancer.
And those optimistic
people have lower incidence of heart disease, better prognosis after heart surgery, and longer
life.
Now, many researches have made
clear that our health is closely associated with psychological factors or so
called stress, and it is the main inducement for various diseases. Such as obesity, cancer, diabetes, heart attack, stress ulcer, mind disorder, Irritable Bowel Syndrome, retard the wound
healing, and so
on.
TCM has been giving much
attention to the factors of psychological, social and environmental, etc.,
especially emphasizing that therapy is made up of the three tenth by medication
and the seven tenth by recuperation psychologically.
“Chinese medicine poetically emphasizes
the harmful role of stress in upsetting the emotional and physical
imbalance leading to a weakened immune system. Western medicine is just
beginning to tap into stress as the root cause of many illnesses and as a major
obstacle in disease management. Chinese medicine has been doing it for over
5,000 years”.
3.1.9.2. Therapeutic effect of
placebo: Indeed there are vivid evidences proved that psychological factors
have therapeutic effect. That is placebo. They were widely used for new
drug’s clinical trial in WM. Although some of them do not have pharmacological
effect at all, however they do made therapeutic action physically.
In 1955, Henry K. Beecher published the
classic work entitled "The Powerful Placebo." He was the first scientist
to quantify the placebo effect. He claimed that in 15 trials with different
diseases, 35% of 1082 patients were satisfactorily relieved by a placebo alone.
“Beecher started a wave of studies aimed at understanding how something (improvement
in health) could be produced by nothing (the inactive placebo).”
“Other studies have since calculated the
placebo effect as being even greater than Beecher claimed. For example, studies
have shown that placebos are effective in 50 or 60 percent of subjects with
certain conditions, e.g., "pain, depression, some heart ailments, gastric
ulcers and other stomach complaints." And, as effective as the new
psychotropic drugs seem to be in the treatment of various brain
disorders, some researchers
maintain that
there is not adequate evidence from studies to prove that the new drugs are
more effective than placebos. “
The therapeutic effects of
placeboes have proven that psychological factors are very important in the
disease’s recovery. The positive frame of mind is conducive to the rapid
recovery of disease. Also proves that TCM is excellent in the philosophical
approaches that started from its origin stage in thousands years ago.
3.1.9.3. Biopsychosocial model:
Until 1977, George Engel coined the biopsychosocial
model, a general theory of
illness and healing, which considered social and psychological factors
associated with physical diseases in WM. Following are some of his articles.
1. Engel GL: The need for a new medical model: a
challenge for biomedicine. Science 8 April 1977; 196:129–136, Number 4286
2. Engel GL: The clinical
application of the biopsychosocial model. Am J Psychiatry 1980; 137:535–544
3. Engel GL: From biomedical to
biopsychosocial: being scientific in the human domain. Psychosomatics 1997;
38:521–528
3.1.10. Chinese drug &
compound prescription
In TCM, there were different
kinds of botanicals, animals and minerals have been riddled and sorted as
medicinal use according to their therapeutic effect. They were used to treat
diseases last thousands years in China.
3.1.10.1. Statistic on Chinese
drugs: According to the largest national investigation in the 80's of 20th century
mainland China, there are 12,807 kinds of Chinese drugs in total. Among them,
11,146 kinds are the medicinal plants, 1581 kinds are medicinal animal, and 80
kinds are medicinal minerals. However, according to the preliminary
statistics in recent years Taiwan, the total number of medicinal plants
was about 8000 kinds. There about 700 kinds were frequently used. The
statistical data from Taiwan is lesser, may be derived from the geographical
limits.
Here I’d like to emphasize that
although the medicinal animals and minerals are lesser in number, however their
therapeutic effects are powerful, so they could not be ignored. I will
demonstrate them later by true examples. I’m sure that the readers would be
attracted and fallen addicted for their excellent therapeutic performance.
3.1.10.2. Compound prescription:
For TCM, the most important therapeutic approach is compound prescription
(multi-pharmacy, compound formula). That is by putting many different kinds of
Chinese drugs in one prescription to treat disease by focusing on symptoms of
syndrome. Some advantages are as following.
Firstly, I would prefer to point
out that, the meaning of symptom in TCM is very different with that of in WM.
In TCM, it is more in macro perspective of philosophical and dialectical rather
than that of specific changes of anatomical and physiological physically in WM,
such as, cold (of Yin) and hot (of Yang). The following content is only an
example from my personal understanding roughly; it is not the same as the
original intent of TCM because that completely understanding and exactly
translating the medical theory of TCM is too difficult for me. It may need to
extend my life to 199 years at least to learn starting from epigraphy on Oracle
bone script in TCM and wording and new words coin in English. Once again, the
purpose of this article is to promote the core of TCM – the Holistic medical
approach rather than clinical reference.
3.1.10.2.1. Focus on the
symptoms: the most disease is a syndrome that appeared many different symptoms
at the same time or at the different development stage. Such as, fever, no
appetite, rhinitis, faucitis, headache, coprostasis, insomnia and so on, TCM prescription
may put many different Chinese drugs for treating each symptom at the same
time.
3.1.9.2.2. Support each other:
Some Chinese drug in compound prescription are not focused on the specific
symptom, only enhance others’ therapeutic effect, For instance, some drugs may
make other drug’s absorption faster, and the elimination slower. Some may
increase the content of other drugs in blood to help absorption. Some can
enlarge the drugs’ delivery amount by vasodilatation effect. Some even can make
produce new therapeutic constituents in blood.
3.1.10.2.3. Relieve side effects:
Such as, some natural drugs may has side effect of causing coprostasis, so put
some Chinese drug of enhancing peristalsis of the alimentary canal to relieve
it, at same time improve the appetite and nutrition supply,
too.
3.1.10.2.4. Improve the appetite
& digestion: The condition of appetite & digestion also affects the
therapeutic effect of the drugs. Unfortunately, that the appetite and digestion
get worse for the most patient. So some drugs that can improve the appetite
& digestion could also enhance the effect of other drugs. Also the
improvement of appetite & digestion can enhance the nutrition supply to
promote the recovery of patient.
3.1.10.2.5. Generate the new
substance: General process method of Chinese drug is cook, and then drinks the
soup. There were reports that some characteristic spectrums of new substance
were found in the liquids from boiling mixed Chinese drugs, it shows some new
constituent were generated during the drugs were being processing.
3.1.10.2.6. Correctness proven
for compound prescription: Cocktail therapy for
AIDS: That is
the simultaneous use of two nucleoside drugs and a non-nucleoside drugs to
treat AIDS, make the HIV virus no where to escape. The inventor, David D. Ho, M.D., the scientific director and
CEO of Aaron Diamond AIDS Research Center in New York, said, that he got
inspiration from principle of the TCM compound formula. So, in fact, the
achievement of the AIDS Cocktail Therapy is the success of the principle of
compound prescription of TCM, although it was more in Reductionistic rather
than Holistic.
Some content of
TCM will be continuously discussed in MCM section.
3.1.10.3. Experience-based
prescriptions: May 1st 2002 the Volume 1 of <Dictionary of Traditional Chinese
Medicine Prescriptions> was published in China. It is a referential
book that carefully sorted and compiled from the experience-based prescriptions
of Chinese medical books in history. The dictionary is about 18 million words
with nearly 100 thousands prescriptions in 11 volumes, which shows the
industrious and wisdom of ancient Chinese people by large amount of medical
records. It has significant referential value for the modern medicine.
If you go to any Chinese Pharmacy
in China or abroad, you will find many bottled tablets OTC Chinese drugs
(CD): 1 Prescriptions Resources: Some of them are experience-based
prescriptions and some of them have been updated according to modern
researches.2 Making Methods: The most of them made by modern processing
methods, Such as, Supercritical Carbon Dioxide Extraction, Sugar coating,
Tablets, Injections and so on. Few of them made by old methods: such as,
Powder, Pill, Salve and so on. 3 Therapeutic range: Various diseases
from Internal, Surgical, Gynecological to ENT. The most of them are focusing on
specific diseases with the role of broad-spectrum treatment, some are for
general physical enhancement. 4Application Level: The most of Chinese
families reserve some often used Chinese drugs for some common diseases, such
as common cold, headache, indigestion, diarrhea, wounds and so on. The most of
Chinese hospital treat diseases by WM integrating CD.
MCM has been developing based on
the TCM by integrating modern biotechnology. Recent decades China, government
made much effort to promote the research of TCM by modern biotechnology,
introduced and developed many modern medical equipments and research methods,
largely stimulated the development of Chinese drugs. And have gotten many
valuable results. Now we can explain the therapeutic effects of Chinese drug
more clearly in modern biological terms from the level of proteins, cells and
gene.
Constituents: For the most Chinese drugs,
such as, herbs, only a single one is a compound that contains dozens or
hundreds of different constituents. So the bioactive constituents are complex
and plenty. Obviously, the nature has prepared what we need and ready to be
explored out.
Classification: The researches show that
the Chinese drugs have been sorted scientifically. For example, those were
sorted as enhancing the digestion are rich in Ca, Zn and Fe, and those as
enhancing male sexual ability are rich in Mn and Cu. It has wonderful orderliness
not only in chemical elements but also in bioactive constituents. Such as,
Wahaha, a therapeutic drink made of Chinese drugs, has been in hot selling
nearly two decades in China. Massive application has proven that it is
effective in treating poor appetite for kids. No precocious puberty happened.
Test results proved it rich in Ca, Zn and Fe.
Bioactivity: The medicinal constituents are
more active in natural drugs than that of any other kind of existence, so that
human body can easily absorb them. For instance, in China, some researchers
compared biological activity of gypsum in the form of nature and manmade,The results showed that only natural
gypsum has therapeutic effect, although the manmade one is in 99.9% pure.
Antibacterial: Various active constituents
in Chinese drugs could kill bacteria or virus directly as well as that of most
Western drug does, fast and accurately at the time regulating the body balance.
The Chinese drugs have showed the both advantages, one is the therapeutic
effects that is similar to the Western drugs and second is the nutritional
effect that is similar to the Orthomolecular
Medicine.
Antiviral: Chinese medicine is the
best anti-viral medicine. It can directly block the synthesis of virus nucleic
acid, which can kill the virus, promote the formation of antibodies, and can
enhance phagocytosis of macrophages to kill pathogenic rapidly and take a
lasting effect.
Synergistic effect: Researches indicate that some
pure extracts reduced their therapeutic effects compared with that were used in
the completely original compound. These maybe caused by losing the potentiating
synergistic effect when some constituents were being filtered away.
Therapeutic mechanisms: Western drug and Chinese
drug has different therapeutic mechanisms due to the difference of their
philosophy. Western drug's entity is manmade single constituent; take the
single effect on specific target. The allopathic is main therapeutic mechanism.
Chinese drug's entity is a group of natural bioactive constituent, take the
multi-effect on the multiple targets with the specificity. The physiological
regulatory is the main therapeutic mechanism.
Smart cure ability: Some Chinese drug can take
intelligent therapeutic effect. For a normal body condition, it does not take
effect; only for an ill body it takes regulatory effect. Some even take
bidirectional regulatory effect. The so-called bidirectional regulatory effect
means that the same drug in same dose can make the unbalanced body condition
return to normal level. Such as: whether the hypertension or hypotension both
can be regulated back to normal level. And no matter is sleepy or insomnia, all
can be regulated back to normal sleep status, and so on.
Brain diseases: Some Chinese drugs
molecular are very small, easily go through the blood-brain barrier to enter
the cerebral cortex directionally and selectively. It can improve the brain
blood circulation, increase the oxygen metabolism of brain cells, and increase
energy supply for cranial nerve system, removal the wastes of the brain
metabolites. Effectively restore the synthesis and metabolism of nerve media
and the central nervous conduction and separation.
Alleviate stress: Chinese drug can reduce the
negative effects of psychological stress largely. Because it can alleviate the
stress symptoms by releasing endorphins, decreasing the stress hormone
cortisol, eliminating the oxygen free radicals, lowering the blood pressure,
reducing the heart rate, relaxing the muscle tissue, improving the digestion
and sleeping, and bringing more fresh oxygen to body tissues by improving the
circulation of blood and lymphatic fluids. This increased blood flow will
eliminate the waste products from inside the body and enhance the nutrition
supply to accelerate the recovery. This advantage can be used to prevent great
many diseases since it reduce the inducement of diseases.
Anti-aging: Chinese drugs can
prolong the life span of organism by many ways, such as anti-oxidation,
immunoregulation, neuro -regulation, endocrine secretion regulation, anti-DNA
injury, etc. It can relieve all the fatigue impairs for men and women, enhance
the ability of hearing and seeing, and restore the color of beard and hair for
elderly.
Broad cure ability: The most often used Chinese
drugs are with have none or little negative effect. Even the little negative
effects can be eliminated easily by compound prescription. It is effective for
both diseases, no matter is communicable or non-communicable. Some examples are
as following:
Resist cancer
development.
Inhibit the cells apoptosis.
Improve the transduction of
cellular signal
Relieve cytotoxic.
Restore the organ or nerve
system.
Reduce the psychic stress.
Improve the digestion and
metabolism.
Relieve the chronic fatigue
syndrome.
Relieve the irritable bowel
syndrome.
Improve the male erectile
dysfunction.
Relieve or heal the psychosis.
Detox the drug addiction
disorders.
Relieve the snore and
apnea.
Prevent or heal heart attack and
stroke.
Substitute blood-dialyze of
uremia patient.
Activate blood flow and removing
blood stasis.
Protect the injury of cerebral or
heart ischemia-reperfusion
Anti-agging.
Prevent or heal
cough.
Relieve neurasthenic.
Cure and prevent the ulcer of
alimentary canal.
Heal chronic tracheitis.
Smooth wound scars.
Relieve or heal arthritis.
Increase white or red blood
cells.
Bi-immunoregulatory effect
And so on.
The list can be made much longer.
But those are enough to make any people understand the wonderful therapeutic effect
of Chinese drugs.
Poison & Safety: Although the Chinese drug
came from nature, however, some of them are not safe for using because of
instant or long-term poison. If we use it correctly, it would be a very good
medicine. Contrariwise, it will cause unexpected results. Now the poison
Chinese drugs have been identified already and have found some special usage in
treating diseases, such as, the arsenic (As2O3)
can be used to cure cancer.
Natural Chinese drugs are a huge
natural pharmaceutical resource, which Western drug does not have presently.
CM integrating WM: Besides bad
negative effects that synthesize drugs have their specific advantages aiming at
some diseases.
Xu Shou (1818-1884), was a pioneer
of modern chemistry China. In his paper "The medical theory" of 1876,
had been put forward the proposition of CM integrate with WM. He wisely pointed
out a promising therapeutic avenue by using both advantages of the CM and the
WM to patch up the disadvantages each other.
Bob Flaws, an active interpreter and
practitioner of Chinese medicine with western background, said
in An Interview, “that the combination
of Western medicinals and Chinese medicinals is, for many disease processes,
better than either of them individually. Typically, you get a better therapeutic
effect with a smaller dosage of Western meds and have to take the Western meds
for a shorter period of time. Clinicians know that most of the side-effects of
Western drugs are dose-related and that, if you can keep the dosage minimal and
the duration as short as possible, you'll get the therapeutic result without
the adverse reactions. Chinese medicinals taken with Western medicines seem, in
many cases, to achieve that therapeutic goal.”
In China, it is common in CM
integrating WM clinically. That is, at the same time, a patient being treated
by two types of medicine. The advantages of WM are to take the effect quickly
toward the main symptoms and the advantages of CM are to take the effect in
eliminating the negative effects of WM by improving the patient's immunity and
overall physical condition. Greatly enhanced the therapeutic effect and made
the patient recover earlier. Also it greatly improved the life quality of
patients. The good example is the treatment of SARS.
SARS: During the outbreak of SARS in
2003 in China, among 5326 were confirmed SARS cases, 3104 were treated by WD
integrating CM. The wonderful therapeutic effect of Chinese drug is manifested.
1. Relieve fever and shorten the
duration.
2. Improve weakness, breath
shortness, dry cough and clinical symptoms of poisoning.
3. Eliminate the toxicity and the
negative effects of Western drug, such as steroid in large doses use.
4. Help to reduce the amount of
using in hormones.
5. Improve hematopoietic function
and hypoxic conditions.
6. Protect the organs function
and avoid organs failure.
7. Reduce the systemic
complications.
8. Promote the absorption of inflammation
to avoid the bad sequels.
Such as the femoral head necrosis
of bad sequelae of SARS.
That the causes are still in
debating, one is SARS virus, and another one is the use of glucocorticoids in
large dose.
As a result, no one was dead in
the group of intervening with Chinese drugs.
N1H1 flu: The successful experience
of mainland China on the treatment of A H1N1 flu was that, if the treatment
focuses on each symptom of the patient to improve their physical condition by
Chinese drugs besides killing the A H1N1 flu viruses. The number of developing
into the critical and death was largely reduced.
It is easy to get some OTC
Chinese drugs in the forms of pill or sugar coated tablets from Chinese
pharmacies closing to your home by consulting seller or Chinese doctor. Please
start with a half of pill or tablet then gradually reach the dose recommended
on the label to avoid the happening of heavy side effect. Also there are
injections that can be used for intravenous infusion, but needs the help of
highly skilled Chinese doctors. Any way flu should not be a deadly disease.
Critical patients: For those
patients in severe critical states, such as, MODS, whatever the causes but no
urinate and defecate for a while, and have no effect on any existing therapies,
we may carefully try to smear the alcohol tincture of Aloe leaf in the navel
and surrounding area about 16 square centimeter, then covering with a plastic
film and massaging to make the medicinals transdermal absorption into the blood
vessel. After about 10 hours, there will be diarrhea-like defecation and then
the patients will feel much better. Smearing several times will be enough. I am
not certain safe or not for the long term smearing. If there is no
diarrhea-like defecation, it may need enlarge the smearing area or check the
quality of the Aloe, whether have enough yellow colored medicinals’ secretions
on the cut section of Aloe leaf. As a safe consideration, firstly smear small
area to watch the patient’s reaction, whether there is side effect. The aloe
must be more than 3 years old so that it has enough yellow colored medicinal.
The navel is a holographic
acupuncture area that can connect human organs of whole body. The Aloe smearing
can restore the digestive system; boost the physiological activities and immune
function with a magical reviving effect.
Above idea enlightened from the
Rhubarb (Dahuang, Jiangjun), a pure Chinese herb with the proven therapeutic
effect for critical patients, such as, for MODS, especially with gastrointestinal
dysfunction. Although the reports of Aloe to be used for critical patients are
less than that of Rhubarb, however, their main medicinal constituent is
similar, so that their medicinal effect will be similar. On the other hand,
compared with Rhubarb, Aloe is easier to be gotten due to it is being home
planted world widely. I will introduce my experience about it home planting in
another article.
Talking about Aloe Vera, the Editor of NaturalNews.com, Mike
Adams wrote that “When I say aloe vera is the most impressive medicinal herb
invented by nature, I don't make that statement
lightly. Of all the herbs I've ever studied -- and
I've written thousands of articles on nutrition and disease prevention --
aloe vera is the most impressive herb of them all.”
A natural, cheaper and simple
method may pull back a person who has stepped into the door of another world
with his or her one foot. The process is just like that makes a nearly
stopped-pendulum re-swing again. There will be much more this kind of simple
experience-based methods in public daily life that is better than those
recommended by so called medical authorities. This is why that I said medical
issue is the public issue, and it should be taken down from the mysterious
Altar.
The method can also be used to
treat children malnutrition, poor appetite, constipation and emaciated, etc.
Please do not long term use.
I do not recommend the use of
Rhubarb unless prescribed by a doctor.
Now I’ll take some individual
medicinal plants, animals and minerals in Chinese drugs as example to
demonstrate the magical therapeutic effect that has revealed by modern
researches.
3.2.2. Medicinal
plant
Here let us look at the
goldthread (Coptis chinensis), a frequently used Chinese plant drug to learn
how an herb works.
Firstly I would like to introduce
a book in which the goldthread was first recorded. The Shen nong ben cao jing, an earliest pharmacy
monograph of TCM, which systematically summarized the clinical experience of
Chinese drugs firstly. It has been hailed as classics and essence of Chinese
pharmacy.
For the publish age, there is a
different legend, one was in the Warring States period 476 BC - 221 BC, and the second was in the age
of Qin and Han Dynasties 221 BC – 220 AD. The authors are unknown.
3.2.2.1.1 Biochemical
constituents
The biochemical constituent
include: Berberine, coptisine, epiberberine, Palmatine, berberis red alkali,
berberis alkali methyl, ferulic acid, magnolia flower alkali, phellodendron
ketones and yellow-corktree bark lactones, etc.
3.2.2.1.2 Pharmacological effects
3.2.2.1.2.1. Antibacterial:
Goldthread preparations have a strong antibacterial effect on pneumococcus,
staphylococcus aureus, streptococcus hemolyticus, comma bacillus, anthrax
bacillus and bacillus dysenteriae, etc. Also has inhibitory effect on the
bacteria of diphtheria, pertussis, tuberculosis and brucella, etc. The coptis
decoction and water extract have inhibitory effect on violet trichophyton,
floccus epidermal mentagrophytes, Candida albicans and Yanuca star bacteria,
etc. And in vitro, show inhibitory effect on mice entamoeba parasite, chlamydi
trachomatis and
trichomonas.
3.2.2.1.2.2. Blood glucose:
Coptis Decoction and berberine gavages may reduce the blood glucose in normal
mice. The hypoglycemic effect may be by inhibiting gluccneogenesis or promoting
glycogen glycolysis.
3.2.2.1.2.3. Platelet and
thrombus: Berberine has significant inhibitory effect on the contraction of
clot enriched with the platelet. After inhibiting the clot contraction, take a
significant catalytic effect on clot lyses caused by urokinase and
streptokinase. It is conducive to save the patients with heart artery
thrombosis or cerebral artery thrombosis.
3.2.2.1.2.4. Heart Function:
Berberine intravenous has a strong positive inotropic effect on canine heart.
So that the rhythm slowed down, the diastolic blood pressure decreased, the
pulse pressure increased, the total external resistance decreased, the blood
output of per pulse increased.
3.2.2.1.2.5. Hypertension:
Berberine can lower down the arterial pressure, particularly diastolic pressure
with the dose correlated. The mechanism is mainly competitive blocking β2
receptor on vascular smooth muscle to reduce the peripheral vascular
resistance. The effect is weaker for stage Ⅲ hypertension and severe hypertension. Such
as:
Berberine tablets 0.6 – 0.8 g.d-1
have good effect on hypertension in stage I & stageⅡ. Also have effect on secondary
hypertension of renal and pre-eclamposia and eclamposia, etc.
Oral Berberine tablets 0.4 ~ 0.5
g per time, 3 times daily for 4 weeks. Results: (1) 13 cases in stage I, 8
cases were marked effect, 5 cases were some effect. (2) 19 cases of stage Ⅱ, 10 cases were marked effect, 6
cases were some effect, and 3 cases were no effect. (3) 10 cases of stage Ⅲ, 2 cases were some effect, 8
cases were no effect. The total effective rate is 73.8%.
3.2.2.1.2.6. Hyperlipidemia: The
hypolipidemic effect is primarily found at the experiment of treatment of
non-diabetic animal models. It significantly reduced the content of serum
triglyceride (TG), total cholesterol (TC) and low density lipoprotein
cholesterol (VLDL2C).
Berberine tablets 0.5 g TID after
meals orally treat hyperlipidemia, the effective rate was 90%.
3.2.2.1.2.7. Myocardial ischemia:
Berberine can enhance the mice’s ability of hypoxia tolerance. Reduce the scope
and extent of rabbits’ myocardial infarction.
3.2.2.1.2.8. Arrhythmia: Oryzanol
significantly increase the oral bioavailability of Berberine. Oral
administration of the blend of two drugs can reduce the arrhythmia of rats
induced by aconitine and coronary artery ligation. The mechanism is inhibiting
outward potassium current and the tail current.
3.2.2.1.2.9. Brain Injury:
Cerebral ischemia can cause the increase of the brain excitatory amino acids,
such as, glutamate. Berberine can improve the brain injury by inhibiting
glutamate-induced high expression of brain cells’ C-fos and the increase of
intracellular calcium.
3.2.2.1.2.10. Cancer: Both in
vitro and in vivo test, berberine shows a significant inhibiting effect for
sarcoma S180 in mice. Also has inhibitory effect on nasopharyngeal carcinoma,
cervical cancer and transplanted tumors of nude mice.
3.2.2.1.2.11.Toxicity: LD50 is
24.3mg/kg by mice intraperitoneal injection.
3.2.2.1.3. Clinic applications
3.2.2.1.3.1. Atrophic gastritis:
Blend preparation of Berberine with other Chinese herbs treat atrophic
gastritis, except 1 patient self terminated, 23 of 24 cases, the gastric mucosal
atrophy was restored to normal, the stomach pain and the gastrectasia symptoms
disappeared, the appetite improved. Gastric analysis: fasting total acidity and
free acidity reached the normal
level.
3.2.2.1.3.2. Stomach and
duodenal: Blend preparation of Berberine and other herbs treats gastritis,
gastric ulcer and duodenal ulcer. Total 18 cases, 12 cases cured in one day and
6 cases in 2 days. Follow-up found relapse patients were re-cured in 1 ~ 2
days.
3.2.2.1.3.3. Ulcerative
Colitis: With metal pipe directly spray Coptis powder and
positioning enema with Coptis powder aqueous solution treat 18 cases of
Ulcerative Colitis, cured 15 cases. Spray method, Coptis powder 2 ~ 2.5 g one
time daily total 9 times for a course of treatment. Enema method, Coptis powder
mixed in 150ml warm water and then poured into. Except pain in first 2 or 3
times, there is no other side effect. The pain can be avoided by adding
appropriate amount of Procaine.
3.2.2.1.3.4. Diabetes: Type II
diabetes 60 cases, oral Berberine 0.3~0.5g X 3 times daily, unknown the time of
treatment course. After treatment, the fasting blood glucose is 117.19 ±
25.98mg/dl, that is significantly decreased than pre-treatment of 208.65 ±
51.68mg/dl (P<0.01). Patients’ clinical symptoms disappeared, serum insulin
levels increased significantly (P<0.01), total effective rate was 90%. Had
no significant effect on those blood glucose level is in
normal. Follow-up 17 cases, there 11 cases were maintained in the
level of treatment efficacy. In the experimental study showed a marked
hypoglycemic effect, and demonstrated the promotion effect on pancreatic β-cell
repair.
3.2.2.1.3.5. Suppurative otitis:
Powder of Berberine with other herbs, blowing into the ear canal, and goes
through the perforation of tympanic membrane, 2 times daily, five days for a
treatment course. Total 41 cases, 36 cases fully recovered, 4 cases improved, 1
case was no effect.
In view of the public Knowledge
on Chinese herbal medicine have been a lot. Here, I’ll introduce the rare one -
medicinal animals.
4000 years ago, there medicinal
animals were used in China. The records were found on the tortoise shells. The
animal names on shells include snake, musk deer, rhino and so on.
Currently, there were 1574 (1581?) kind medicinal animal’s recorded. Among them,
the terrestrial animals are 1295 kinds; the marine animals are 275 kinds. The
vertebrates are about 62% in the medicinal animal species. The invertebrates
are 606 kinds.
In TCM, the ants are used for
treating many diseases, such as, kidney inefficiency, rheumatic pain, stroke
hemiplegia, hand-foot numbness, dizziness, tinnitus, insomnia, dreamy,
impotence, emission, lupus, scleroderma, dermatomyositis, carbuncle, swollen
pain and snakebite, etc.
3.2.3.1.1. Bioactive constituents
3.2.3.1.2. Pharmacological effects.
3.2.3.1.2.3. Inhibit
inflammation: Experiments show that ants can significantly inhibit the
inflammation induced by xylene and formaldehyde. This provides a reliable
theoretical basis for clinical application of ant to treat rheumatic diseases.
3.2.3.1.2.5. Asthma: Ants
preparation can relieve the bronchial asthma and intestinal spasm induced by
ethylene choline. And can relieve the intestinal spasm induced by barium
chloride.
3.2.3.1.2.6. Sedative effect:
Ants preparation can reduce the times of spontaneous activity of mice, showed
certain sedative effect.
3.2.3.1.2.7.Painkiller: Experiment in mouse
acetic acid writhing response showed that ants have very significant effect in
relieving throes. The pain threshold was increased 4.347 times.
3.2.3.1.2.8.
Liver: Ants preparation can lower down the activity of rat’s serum
glutamicpyruvictransaminase enhanced by carbon tetrachloride. Show that ants
can inhibit the hepatocyte fatty change.
3.2.3.1.2.9. Anti-aging: Ants can
increase the content of intracellular DNA and RNA, enhance the phagocytosis
capacity of the macrophage, and scavenge free radicals
3.2.3.1.2.10.
Sex: Ants are a sexual enhancer to promote the sexual ability by
making following improvements: (a) Increase the weight of the testes and ovary.
(b) Increase the content of DNA, RNA in leydigscells and spermatocytes of
convoluted suminiferous tubule. (c) Promote the cell division. Experiment show
that ants can increase the weight of semen capsule prostate and glandulae
preputiales of castrated male mice, increase the weight of spermary and
epididymis of normal mice markedly and significantly increase the number of
sperm. For aged mice increase the weight of testes and thymus.
3.2.3.1.2.11.Fertility: Ants have a
significant effect in the promotion and protection for the fetal rat growth.
And have satisfactory effect on the treatment of infertility of men and women.
Such as, azoospermia; oligospermia; non-ejaculation; varicocele; endometriosis;
amenorrhea; ovarian cysts; uterine hypoplasia; irregular menstruation;
no-ovulation; polycystic ovary syndrome and bilateral tubal barrier.
3.2.3.1.2.12.Diabetes:Ants can regulate the disorder of
endocrine function in vivo, enhance the metabolism of the sugar, protein and
fat, and stimulate the cell function. Thus, enhance the activity of insulin and
inhibit the generation of insulin antibody. Improve the fatigue phenomenon. In
China, more and more patients use ants and herbs compound to treat diabetic
syndrome.
Total 56 out-diabetes
patients, 21 males and 35 females, 9 were over 60, 26 were 45-60, and 21 were less than 45.
The course of disease was from 6 months to 4 years. All these patients had
varying degrees of oral thirst, rapid hungering, polyuria, obesity or
emaciation, and generalized lack of strength. Fasting blood glucose was equal
to or more than 7 mmol/L (126mg/dL) and glycosuria was +-++++.
Ants 60g and another
19 Chinese herbs ground into fine powder and disinfected. 10 capsules
(0.3g/capsules) X 3 times daily, 3 months equaled one course of treatment.
After 2-5 such courses, outcomes were assessed.
There were 38 patients (67.9%)
were marked effect, 12 patients (21.4%) were some effect, and 6 patients
(10.7%) were no effect, for a total amelioration rate of 89.3%. However, these
effects were most significant in those with the early stage of disease in
asymptomatic. According to the Chinese authors of this study, there were no
observable side effects from this protocol.
“Researchers at
Princeton and Harvard Universities believe that the discovery of two key proteins guiding
one of the two groups of pathogenic bacteria that make up an ant's outer shell
could pave the way to the development of new antibiotics.” ”the antibiotics
would be particularly effective against gram-negative bacteria, such as E
coliand Salmonella, and would destroy these pathogens by disabling the
mechanism that produces the ants' protective coating.”
3.2.3.1.2.14. Cancer:
Radiotherapy and chemotherapy will seriously damage the patients’ immune
system. Ants can provide compensation to restore being destructed immune
system. At the same time, those increased natural killer cells can kill cancer
cells directly.
Here is a miracle recover case of liver
cancer.
Suppose that Mr. Yu took the
conventional treatment with radiotherapy or chemotherapy, he would be died
already. Even if alive he would be at counting his remaining survival days or
months on bed by bending his finger according to the general experience,
because that the liver cancer is a badly malignant one, so that it is being
called the king of cancers’.
Indeed, in above case, it was
that incurable cancer is cured by animal drug without help of conventional
medical means. Obviously no any constituents that can kill cancer cell directly
in ant powder. However, it was that the ants killed incurable cancer cell
indirectly by enhancing Mr. Yu’s immune ability. Therefore, it is the success
of holistic philosophical approach. The fact has provided a powerful evidence
to prove the system biology is a prospective philosophical approach and that
the nature killer cells
kill cancer cell is effective in vivo.
Suppose take the ants regularly
as preventatives before, Mr. Yu would not be suffered in cancer.
Acute toxicity test:
LD50>215000mg/kg.
Ames test: No findings on cancer
mutagenicity in following test. the concentration of Ant powder in 1.0
mg/plate. 2.0 mg/plate 3.0 mg/plate and 4.0 mg/plate orderly were studied with
TA97(a), TA98, TA100, TA102 bacterial, at the same time, mutagenic were used as
the control groups. The test was repeated under the action of metabolic activated
enzyme. The bacterial numbers at every concentration had no significant
differences than the control groups.
Micronucleus test: No significant
different with control group in bone marrow cytogenetic test: Micronucleus rate
at 5000mg/kg, 10000mg/kg, 20000mg/kg and positive were 0.2%, 0.16%, 0.18%,
0.2%, 3.26% respectively.
The sperm shape abnormality test:
No significant different with control group in following tests: 5000mg/kg,
10000mg/kg、 20000mg/kg
and positive were 1.94%, 1.98%, 2.24%, 12.84%.
Thirty days feeding test: All
histopathologic and biochemical indexes were in normal after 30 days feeding.
Including blood, liver, kidney, stomach, intestines, growth status, all results
were negative. The facts indicated that Ant powder is non-toxic.
Following are some studying
articles for ants in medicinal practice.
U.N. Conference
Promotes Insect-Eating for Everyone From Famine Victims to Astronauts
Colombia's Big-Butt
Ants Entice Gourmets
'Big-Butt' Ant
Delicacy Goes Global
Ants Have Much More
Efficient Antibiotics Than Humans Do
Extracts in Chinese
Ants May Fight Against Arthritis and Others
New Slant On Ants: Eat
Them And Stay Healthy, Chinese Say.
BEIJING - A handful of
ants a day keeps the doctor away, according to Chinese scientists.
Ants May Help
Researchers Unlock Mysteries of Human Aging Process
Insects and other arthropods used as
drugs in Korean traditional medicine
Placenta is the unique
organ and the initial home for therian mammals.
The medicinal use of placenta
started around 2200 years ago. The first Emperor, Qin
Shi Huang, the man
who made China and tasted the placenta firstly on the purpose of prolonging his
life. He felt it did work and ordered to take it as top grade tonic in royal
regimen. Thereby the kings in subsequent dynasties of China took placenta as a best
tonic, too. They conducted some studying on placenta and used it as a special
drug clinically.
In TCM book, the Compendium of Materia Medica has an attractive
description: the placenta of human, sheep, pigs, cattle, deer and other
mammals’ can be used as drug. They can relieve all the fatigue impair for men
and women. Even those in critical condition, take 1 or 2 times, can be
survived. Adhering long-term use, can enhance the ability of hearing and
seeing, and can restore the color of beard and hair for elderly, benefit to the
health and longevity. It is a magical panacea medicine.
3.2.3.2.1. Bioactive
constituents: Modern Pharmacological studies indicate that the placenta
contains at least 55 kinds of bioactive nutrients that play an important role
in human life. There are more than 30 kinds of essential amino acids,
multi-vitamins and trace elements. Among all of them, the important one is
placental peptide; the peptides are the biological active substances that
involved in a variety of cell functions in vivo. Almost all cells are subject
to peptide-regulating in multi-aspect, such as, hormones, nerves, immune
regulation, tumor, neurohormonal neurotransmitter regulation, cells’
reproduction and differentiation, etc.
3.2.3.2.2.
Pharmacological effects
3.2.3.2.2.1. Immunoregulatory:
Placental Immunoregulatory peptide can significantly promote the growth, maturation
and differentiation for human T lymphocytes and B lymphocyte. It can
significantly improve the immune function of mice in radiotherapy and
chemotherapy. For the mice that are in immunosuppressive state, the placental
peptide can restore the immune ability by increasing the number of neutrophils,
the index of body weight, spleen weight and lymphocyte stimulation, etc. After
10 days administration of sheep placenta peptide on puppies, found that many
physiological indicators were significantly increased. Such as, total number of
blood leukocytes, peripheral blood T cells, serum globulin levels, serum
lysozyme activity, etc.
3.2.3.2.2.2. Fatigue and hypoxia:
In mice model, placental preparation can enhance the capacity of anti-fatigue
and anti-hypoxia. It can significantly increase the time of load swimming.
Experiments show that the blend preparation of deer placenta with herbs can
extend the sustained swimming time in mice and hypoxic survival time of rats.
Increase the human muscle endurance, so that after exercise the body's blood
pressure, heart rate were all reduced, and in serum those related to energy
metabolic enzymes and energy supply substance can be all increased.
3.2.3.2.2.3. Anti-aging:
Placental preparation can take an anti-aging effect through scavenging the free
radicals by enhancing the activity of superoxide dismutase. Experiments show it
can significantly reduce the lipofuscin content in the tissue of mice brain,
thus reducing the damage of brain tissue and slowing down the development of
aging.
3.2.3.2.2.4. Cell: Placental
preparations can promote the proliferation and metabolism of the cells. With
the experiment of DMEM cultured epidermal basal cell of neonatal mouse,
confirmed that the extract of placental tissue have the effect of the nutrition
and growth factor. Now it is used to make cosmetics due to its capacity of
removing wrinkles and enhancing skin elasticity.
3.2.3.2.2.5. Intellect: Placental
preparations can improve the learning ability. Experiments proved that the
Placental Immunoregulatory Factor (PIF) can improve the learning ability of
mental retarded children. In rat’s Alzheimer's disease model, in placental
group, the score of learning and memory test was superior to the control group.
3.2.3.2.2.6. Eyes: Placenta
preparations can induce the generation of the cells melanin to take the
therapeutic effect for retinal malnutrition of myopia and age-related.
3.2.3.2.2.7. Gynecological:
Placental preparations can treat some gynecological problems. Such as, uterus’
hypogenesis, follicle presenility and serious early amenorrhea, etc. The effect
is significant better than that of WM hormone treatment.
3.2.3.2.2.8. Live: Treats
hepatitis-C 115 cases by placental peptide, there 91 cases were cured
clinically. The cure rate reached 79.1%. Show that the placenta peptides have
the effect of anti-hepatitis virus in vivo. The mechanism maybe is that
regulate the cellular immune function.
3.2.3.2.2.9. Respiratory:
Placental peptides have significant therapeutic effect on respiratory diseases.
Such as, chronic bronchitis and bronchial asthma, etc. For instance, treat
chronic bronchitis by single placenta; the total effective rate was 64%. After
integrated with WM drugs, the total effective rate reached 84%, were
significantly higher than 53% in single WM drug group.
3.2.3.2.2.10. Cancer: As adjuvant
treatment of chemotherapy for tumor bearing mice, show that placental peptides
can increase the total WBC number of peripheral blood, thereby regulate the
physiological function, repair the damaged tissue and cells. Placental peptide
can inhibit the growth of S180 tumor cell and colon tumor cell, the inhibition
rate was 48% and 57%. After the treatment by radiotherapy integrating placental
Immunoregulatory factor for nasopharyngeal cancer patients, the level of CD4,
CD4/CD8 and the activity of NK cells’ were significantly increased.
3.2.3.2.2.11.
Graft-versus-host: Placental immunoglobulin can effectively inhibit
early differentiation of T lymphocytes, induce the immune deviation of the T
cells; take the effect in preventing mice graft-versus-host disease.
3.2.3.2.2.12. Tuberculosis: Human
placental lipopolysaccharide has adjuvant therapeutic effect on tuberculosis.
3.2.3.2.2.13.Sleep:When massive crowd efficacy
testing, found that the sheep placental preparations can improve the sleep
quality.
3.2.3.2.2.14. Digestion: In mice
model, intraperitoneal injection of Sheep’s Placental Living Cell Extract,
found that the level of gastrointestinal impel reached 64.57% ± 10.81%, is
significantly higher than that of 56.12% ± 12.48% of control group. The result
indicates that the Sheep Placental Living Cell Extract can enhance gastric
peristalsis, therefore improve the digestion.
3.2.3.2.2.15. Beauty: Placental
preparations can make the human skin beautiful and extend the adolescence by
regulating the endocrine, dissolving the aged rough skin and repairing the
injured skin tissue.
3.2.3.2.2.16.Various diseases:
Placenta-related preparations also demonstrated good clinical results on
various diseases. Such as, malnutrition, rhinitis, psoriasis, leucoderma, chickenpox,
chronic gastritis, pelvic inflammation, nervous headache, stroke sequelae,
acute leukemia, some eye diseases, etc.
3.2.3.2.2.17. Poison: Do not find
the report on LD50 for placenta currently. As a kind of meat that placenta
should be safe in any dose obviously.
Following are some
articles on placenta.
Researchers find blood
stem cells originate and are nurtured in the placenta
Tumor-suppressor gene
is critical for placenta development
Key to early diagnosis
of autism may be in the placenta
Discarded placentas
deliver researchers promising cells similar to embryonic stem cells
Placenta Is A Rich
Source Of Blood Stem Cells
Cure for Postpartum
Depression
Our most familiar special animal,
the one is between the insects and mammals have a wonderful therapeutic effect.
Its medicinal use started around
2000 years ago China, which recorded in the book Divine Farmer’s
Materia Medica Classic.
In TCM, the earthworm’s
preparations were used to treat asthma,mania, cancer, hypertension, hemiplegia, chronic
bronchitis, oliguria edema, arthralgia numbness, limb numbness, stroke sequelae
and high fever shock convulsive
epilepsy.
3.2.3.3.1. Bioactive constituents
Modern pharmacological researches
indicate that earthworm contains plenty bioactive constituents, includes
adenine, guanine, choline, xanthine, succinic acid, earthworm kinase, earthworm
toxin, earthworms antipyretic alkali, nitrogen substances, glutamic acid and 6-hydroxy-purine,
etc.
3.2.3.3.2. Pharmacological
effects
3.2.3.3.2.1. Antithrombotic and
thrombolysis: The earthworm kinase has good effect on antithrombotic and
thrombolysis. It can also repair the tissue necrosis on the surrounding area of
cerebral infarction and cerebral thrombosis, and improve the stroke sequelae.
The earthworm fibrinolytic enzyme, extracted from the earthworm, have
thrombolytic fibrinolytic effect and plasminogen activator effect. It can not
only dissolve the plasminogen-rich fibrin clots, but also dissolve
non-plasminogen fibrin clot.
3.2.3.3.2.2. Antipyretic: The
earthworm antipyretic alkali has antipyretic effect. In guinea pigs model, the
body temperature can drop 0.7℃ in half an hour. The antipyretic principle is
that the earthworm antipyretic alkali regulate the thermoregulation nerve
center, heat loss was increased, at the same time, the body heat production
also increased. However, the former is over the latter, and thus the body
temperature was dropped. The earthworm water-soluble extract have good
antipyretic effect for rabbits fever induced by coli endotoxin. The cooling
effect is moderate than antipyrine.
3.2.3.3.2.3.
Digestion: A combination of herbs and earthworms, or lumbricus can
tonify the sympathetic and parasympathetic functions of the central nervous
system, thereby enhancing the digestive function in the stomach and the
gastrointestinal tract.
3.2.3.3.2.4 Sedation and
anticonvulsant: In mice and rabbits model, hot alcohol lixivium of earthworm
showed sedative effect and antagonistic effect for convulsions induced by
electricity, pentetrazole and caffeine.
3.2.3.3.2.5. Antihypertensive:
Earthworm preparations have moderate and long-term hypotensive effect. It was
proved in the models of rats, cats, anaesthetized dogs and chronic renal
hypertensive rats. Hypotensive mechanism related with the central nervous
system above spinal cord, because the antihypertensive effect disappeared after
cut off the cat second section of cervical spinal cord.
3.2.3.3.2.6. Vasoconstriction and
Vasodilator: Earthworm extracts have strong long-term excitatory effect on
smooth muscle organs, can cause spastic contraction. Experiments show that it
has exciting role for uterine in vitro and in vivo. With the dosage increased
the uterine contraction increased significantly, thus enabling an immediate
increase in tension, blood pressure dropped to zero to deaths. Experiment in
vitro with variety of smooth muscle organs, that earthworm lixivium can enable
vasoconstriction in direct effect, and can enable vasodilator by effect through
the central nervous system.
3.2.3.3.2.7.
Antibacterial: Earthworm antibacterial peptide has a broad range of
anti-bacterial effect with strong vitality. Earthworm’s extracts have a strong
antibacterial effect on human type mycobacterium tuberculosis.
3.2.3.3.2.8. Cancer: Inhibiting
the growth of MGC~03 gastric cancer cell and mouse transplanted tumor (S180 and
H22). Remission rate was significantly higher than that of control group in
treating esophageal cancer (331 cases), lung cancer (155 cases) without any
side-effects.
3.2.3.3.2.9. Poison: Earthworm’s
LD50 is 1213mg/kg.
Some study articles are as
following.
Earthworms Have Been
Used in China, Korea,and Most of Southeast Asia for Thousands of Years
Earthworm powder,
fibrinolytic enzymes without the risk of hemorrhage.
Metal-munching
earthworms could be the “21st Century eco-warriors”
Earthworm extracts for
anti-inflammatory, analgesic
Cell adhesion and the
immune system: a case study using earthworms
A Glimpse of The
Traditional Medicines Of Animal Origin
The Useful of
Earthworm Powder For Human Care!
Anticoagulant effect
of earthworm powder on experimental rabbit
Antimicrobial defense
of the earthworm
Earthworm immunity: a
model of immune competence
Hypothetical mode of action of earthworm
extract with hepatoprotective and antioxidant properties
Anti-inflammatory and
anti-pyretic activities of earthworm extract—Lampito mauritii (Kinberg)
Do earthworms have any
medical uses?
Boluoke:
Fibrin-dissolving enzyme from earthworms that protects from heart disease
Earthworm fibrinolytic
enzyme:anti-tumor activity on human hepatoma cells in vitro and in
vivo
Novel thrombolytic
therapy discovered from traditional oriental medicine using the earthworm.
Earthworm extracts help relieve asthma
symptoms
Cerebral apoplexy and
Chinese medicine (fibrinolytic activity of earthworm).
The first record of the medicinal
use of minerals was found in <Zhou LI>. The publish time was
estimated at the age of 725 BC - 645 BC according to the book has mentioned the
economic activity of Guan Zhong of a famous ancient
politician China.
Gypsum (Shi Gao) (CaSO4·2H2O), a mineral we are
most familiar since it is used to fix the bone fracture by doctors. Also being
used to treat various diseases for a long times due to its wonderful
therapeutic effect in China.
The record of Gypsum’s medicinal
use was found in Ming Yi Lu firstly, a book published in Tang Dynasty. It was a biographies for 120 famous doctors from San Huang (3000 BC - 2700 BC) to Tang Dynasty (618 AD-907 AD), which covered thousands years historical span in
China. The book mentioned the gypsum as medicinal use. It said that a female
patient with hyperpyrexia and cold. Failed in treatment by many TCM doctors,
however she was cured by a TCM doctor with gypsum finally. The case maybe
happened much earlier than that of book publish age. It means that gypsum used
as a drug is much earlier, too.
In TCM, the gypsum has been using
to treat diseases as following.
1. Orally administration: chronic
hyperpyrexia,exanimation, delirious speech, fidget, thirst, dry
throat,wheeze,heatstroke, spontanous sweating,headache,toothache,exanthesis,ulcers in the mouth and on the
tongue, etc.
2. External smear with baked
powder: Treat the scald, fire burns and chronic fester by promoting the tissue
regeneration.
3.2.4.1.1. Pharmacological effects
3.2.4.1.1.1. Antipyretic effect:
Gypsum can inhibit the over-excited thermoregulation central nerve system
during fever to take a strong and quick cooling effect. Gypsum Decoction has
disincentive effect on inducing iatrogenic fever by leukocyte. Gavages 2g/kg
raw gypsum has an antipyretic effect on rabbit fever caused by E. coli
endotoxin. Has no effect on normal rabbit.
3.2.4.1.1.2. Anti-inflammatory:
Gypsum react with the gastric acid, partially become the soluble calcium salt.
It can increase the concentration of the serum calcium after being absorbed
into the blood in intestine. The increased serum calcium can inhibit the nerve
stress energy (including thermoregulation central nerve system), reduce the
excitability of the skeletal muscle, alleviate the muscle spasm and reduce the
vascular permeability to take the effect of detoxification, anti-spasm and
anti-inflammatory.
3.2.4.1.1.3. Immunity: Gypsum
decoction 1:4 concentration 4ml gavages can increase the content of macrophages
cAMP of spleen and peritoneal for Burned rats. Gypsum preparations can increase
the number of T lymphocytes, increase the rate of lymphocyte transformation and
enhance the phagocytosis of peritoneal macrophages.
3.2.4.1.1.4. Convergence
role: External use calcined gypsum has an effect of converging
mucosa to reduce the secretion.
3.2.4.1.1.5. Anti-virus: By
dot-blot hybridization experiments, 25%-100% concentration of gypsum decoction,
have the effect on lower the content of deoxyribonucleic acid (HBV DNA) in the
poison of Hepatitis B.
3.2.4.1.1.6. Diuretic and
choleretic: Increase the urine output for mice and increase the bile output of
rats and cats.
3.2.4.1.1.7. Cardiac excitatory
and inhibitory: Low-dose gypsum infusion has an excitatory effect on isolated
heart of toads and rabbits and inhibitory effect in large doses.
3.2.4.1.1.8.Analgesic:Gypsum injection can inhibit the
evoked potentials in cortical somatosensory areas, which caused by afferent
impulse of C saphenous nerve fibers of cat. So that it can take a selective
central nerve analgesic effect.
3.2.4.1.1.9. Muscle cramps:
Gypsum preparations can inhibit the excitability of skeletal muscle, reduce the
vascular permeability and ease muscle cramps.
3.2.4.1.1.10. Thirsty:
Gypsum decoction can reduce the thirsty status of the rats.
Clinical Applications:
He clinically comprehended that
the hyperpyrexia is the acute severe diseases. The most patients were turning
to seek hope in TCM after failed in WM treatment. They are all in poor
prognosis in complex condition. Clinical symptom of those patients are the
temperature sustained over 39℃, the fever degree is asymmetry on the body
bilaterally. Patient is anhidrotic, and the blood leukocyte is in normal level
usually. It may be the central hyperpyrexia caused by dysfunction of central
thermoregulation nerve system. In which situation, the general physical cooling
methods and the WM antipyretic drugs are usually ineffective. And the
hibernation therapy has many side effects,
unfortunately.
Application in Farm:
Miscellaneous chicken
300, all were infected with chicken infectious bursal disease, died 92
in five days, there were 91 could not stand up. After gavaging decoction of
gypsum 210 g and brown sugar 420 g, all chickens’ ill symptoms were improved.
Next day one more time decoction gavaging, all chickens was survived.
Only natural gypsum has
antipyretic effect although the manmade one is in 99.9% pure. The fact shows
that the calcium is not the main constituent of the actual pharmacological
effect. Then, what is it? It still is a mystery waiting to be
answer.
3.2.4.1.1.11. Poison
of Gypsum?
Mammals - Acute oral
LD50 (mg kg-1) 5050 E4 Rat
Mammals - Dermal LD50
(mg kg-1) 8480 Q3 Rat
For the safety of gypsum, we can
evaluate out a positive answer from dozens cases of suicide by gypsum, which
happened in Iran. No one died and no any sequelae.
“A 48-year-old-male
patient attempted suicide by ingesting a large amount (more than three
glass≥750 ml)of a solution composed of plaster in
water. The
patient had experienced mild abdominal cramping (restricted to the epigasteric
region) and watery diarrhea following ingestion. Ten days after, he developed
melena, nausea, and vomiting. On arrival at the emergency ward, two weeks
post-ingestion, he was alert, and was admitted suspecting for bowel
obstruction.”
“Vital signs were blood pressure
120/70 mm Hg, temperature 36.6 ℃, heart rate 76/min, and respiratory rate 16/min.
On clinical examination, there was no abdominal distention, tenderness or
rebound tenderness, and also no abdominal mass was palpable.” “He did not
present with a toxic syndrome consistent with other ingestants.”
“three masses of
plaster were totally removed (measuring 3cm × 3cm × 3 cm, 5cm × 3cm ×
3cm and 7cm × 7cm × 7cm) by an anterior gastrotomy.” “The patient
resumed oral intake on the second post-operative day and returned to normal
activity on the 3rd post-operative day.”
“Calcium sulfate
hemihydrate has been used for many years and is still used extensively in both
industrial and consumer areas. While bowel obstruction has been considered as a
consequence of plaster ingestion, documentation of recent such case reports in
the medical literature are lacking and therefore, we report such a case for the
first time to our knowledge. Our investigation of literature identified one
large review on suicide attempt by plaster ingestion in an Iranian national
journal (Iranian Journal of Legal Medicine). In this only previous study,
the authors reviewed demographic features and endoscopic results of forty
patients admitted to a general hospital in one of the western states of
Iran (Kordestan), with a history of plaster
ingestion between 1997 and 2000. Twenty-three of the patients (57.5%) were female and 17 (42.5%) were male. The majority of
patients (45%) were in the range of 10~19 years, which
correlates well with previous data on the prevalence of suicidal behavior.
37.5% of the victims were student and 35% were housekeeper. All of the suicide
attempts were by ingestion and in the form of water soluble. In their report of
these forty cases, Yeganeh, et al. found that the most common symptom was abdominal
pain (42.5%) followed by vomiting(15%). The most commonly reported sign
was a palpable abdominal mass, which was detected in the 17.5% of the patients.
Fifty percent of patients had no remarkable sign or symptom. No toxicological
data were given, but there were no remarkable abnormality in the laboratory and
biochemical analysis of the patients.”
3.3.
Meridians & Acupuncture
Meridian: is a network system throughout our body with
therapeutic function.
2,500-year ago, the Huang Di Nei Jing, a masterpiece of Chinese
medicine, firstly coined the Meridian, and forged cornerstone of acupuncture
and Chinese medicine in comprehensive written. In recent decades, some
historical literature of Meridians has been unearthed from the tomb gradually.
Such as Silk Books, bamboo slips books and men's Meridian model made in copper
and wooden.
They described that throughout
our body has a network system that consists of 12 regular meridians and 8
extraordinary meridians.
The 12 regular meridians consist
of 6 Yin Meridians and 6 Yang Meridians, which connect to specific splanchnic
organ separately. The feature of their distributing on the surface of human
body is as following:
a. Distributed symmetrically and
lengthways.
b. The 6 Yin Meridians
distributed on the chest, abdominal and medial side of limbs. There are five
connect to lung, heart, spleen, liver and kidney separately, and the other
ones* connects to the part that surrounds the heart.
c. The 6 yang Meridians
distributed on face, head, trunk and lateral side of limbs. There are five
connect to stomach, large intestine, small intestine, bladder and gallbladder
separately, and the other ones* connects to the organs inside of the chest and
the abdomen.
*. The concept of the other ones
can not be explained detailedly due to it is very complicated.
In the 8 extraordinary meridians,
the two have their own sets of acupoints, and the other 6 interconnect across
with the 12 standard meridians and share the acupoints with them. They enhance
the links between 12 regular Meridians. The feature of their distributing is as
following:
a. No connect with splanchnic
organs directly.
b. No connect between each other
directly.
c. No distribute on arms.
Meridian system is Similar to the
modern highway networks. The difference is that Meridian network on the surface
of the body have linked with splanchnic organs to form a complex
three-dimensional network while modern highway network being a plane one.
Acupuncture: The acupuncture
points were located on the meridians. The therapeutic mechanism of acupuncture
is that will get response on the specific organ or area by stimulating specific
acupoints to realize therapeutic purposes physically.
Then, what is the nature of
Meridian system? It is difficult to explain currently. Because of Meridians
were not found visually in modern anatomy.
However, research results for
examining Meridians by the means of biological physics, indirectly proved that
it is there. For instance:
By gamma camera filming, found
that the track of isotope movement on body is consistent with distribute
direction of the specific meridian channel. By measuring the electrical
resistance, found that there is very little resistance between the two
acupoints on the same Meridian Channel. However, there is a great resistance
between the two acupoints that is not on the same Meridian Channel although
they are very close. And so on.
3.3.1. Effective evaluation of acupuncture
May 11, 2009, The Herald-Mail reported that Area moms say
acupuncture helped them to conceive in Hagerstown city, Maryland State, USA.
Those moms are failed in pregnancy after various attempts. However they were
conceived and gotten healthy babies with the help of acupuncture and Chinese
herbs. Following photo is Kelly Morton with her lovely daughter.
Kelly Morton, 37, of Hagerstown
holds daughter Sadie, 8 weeks, in front the wall of children who have been
conceived using Chinese medicine. Sadie was conceived with the help of
acupuncture and Chinese herbs.
BMJ,
doi:10.1136/bmj.39471.430451.BE, (Published 7 Feb. 2008)
Abstract: Objective: To evaluate
whether acupuncture improves rates of pregnancy and live birth when used as an
adjuvant treatment to embryo transfer in women undergoing in vitro
fertilisation.
Data sources: Medline, Cochrane
Central, Embase, Chinese Biomedical Database, hand searched abstracts, and
reference lists.
Review methods: Eligible studies
were randomised controlled trials that compared needle acupuncture administered
within one day of embryo transfer with sham acupuncture or no adjuvant
treatment, with reported outcomes of at least one of clinical pregnancy,
ongoing pregnancy, or live birth. Two reviewers independently agreed on
eligibility; assessed methodological quality; and extracted outcome data. For
all trials, investigators contributed additional data not included in the
original publication (such as live births). Meta-analyses included all
randomised patients.
Data synthesis: Seven trials with
1366 women undergoing in vitro fertilisation were included in the
meta-analyses. There was little clinical heterogeneity. Trials with sham
acupuncture and no adjuvant treatment as controls were pooled for the primary analysis.
Complementing the embryo transfer process with acupuncture was associated with
significant and clinically relevant improvements in clinical pregnancy (odds
ratio 1.65, 95% confidence interval 1.27 to 2.14; number needed to treat (NNT)
10 (7 to 17); seven trials), ongoing pregnancy (1.87, 1.40 to 2.49; NNT 9 (6 to
15); five trials), and live birth (1.91, 1.39 to 2.64; NNT 9 (6 to 17); four
trials). Because we were unable to obtain outcome data on live births for three
of the included trials, the pooled odds ratio for clinical pregnancy more
accurately represents the true combined effect from these trials rather than
the odds ratio for live birth. The results were robust to sensitivity analyses
on study validity variables. A prespecified subgroup analysis restricted to the
three trials with the higher rates of clinical pregnancy in the control group,
however, suggested a smaller non-significant benefit of acupuncture (odds ratio
1.24, 0.86 to 1.77).
Conclusions: Current preliminary
evidence suggests that acupuncture given with embryo transfer improves rates of
pregnancy and live birth among women undergoing in vitro fertilization.
Acupuncture could obviously improve the cerebral
vasomotoricity of the patients with cerebral ischemic stroke. The mechanism is Acupuncture
could improve the cerebrovascular function, improve the cerebral blood
circulation, so as to provide abundant blood for the focal area and the
neighboring ischemic area, to prevent the nerve cell from necrosis and
accelerate recovery of the impaired neural system, thus obtain the therapeutic
purpose.
Germany has conducted the
largest clinical trials of acupuncture ever undertaken. About 500,000 patients
were included in these ambitious projects, which are sponsored by four large
health insurance companies. As an aftereffect, now, there are five big
acupuncture research centers are financed by the German government. German
insurance companies spend some 600 million marks a year for acupuncture therapy. Also it will be paid by the German social insurance scheme if administered by a
qualified acupuncture physician for chronic low back pain and osteoarthritis of
the knee.
A study conducted in UK has shown that the
acupuncture is definitely effective in chronic headache, and is reported in the
British Medical Journal.
Acupuncture in patients with chronic low
back pain: a randomized controlled trial.
Methods: Patients were randomized
to treatment with acupuncture, minimal acupuncture (superficial needling at
non-acupuncture points), or a waiting list control. Acupuncture and minimal
acupuncture were administered by specialized acupuncture physicians in 30
outpatient centers, and consisted of 12 sessions per patient over 8 weeks.
Patients completed standardized questionnaires at baseline and at 8, 26, and 52
weeks after randomization. The primary outcome variable was the change in low
back pain intensity from baseline to the end of week 8, as determined on a
visual analog scale (range, 0-100 mm).
Results: A total of 298 patients
(67.8% female; mean +/- SD age, 59 +/- 9 years) were included. Between baseline
and week 8, pain intensity decreased by a mean +/- SD of 28.7 +/- 30.3 mm in
the acupuncture group, 23.6 +/- 31.0 mm in the minimal acupuncture group, and
6.9 +/- 22.0 mm in the waiting list group. The difference for the acupuncture
vs minimal acupuncture group was 5.1 mm (95% confidence interval, -3.7 to 13.9 mm;
P = .26), and the difference for the acupuncture vs waiting list group was 21.7
mm (95% confidence interval, 13.9-30.0 mm; P<.001). Also, at 26 (P=.96) and
52 (P=.61) weeks, pain did not differ significantly between the acupuncture and
the minimal acupuncture groups.
Conclusion: Acupuncture was more
effective in improving pain than no acupuncture treatment in patients with
chronic low back pain, whereas there were no significant differences between
acupuncture and minimal acupuncture.
The minimal acupuncture by
superficial needling at non-acupuncture points was being called as sham
acupuncture. It does make therapeutic action. From this kind of phenomenon,
some people questioned the validity of Meridian theory. I think that main
reason of the phenomenon is placebo effect psychologically and others are that
the mechanism of acupuncture is not quite clear.
3.3.2. Meridian & Chinese
drugs
The therapeutic mechanism of
Chinese drugs is similar to the acupuncture, that is Chinese drugs can enrich
in specific organs or parts to take the therapeutic effect on the enriched
area. Therefore, the treatment of different diseases in TCM will use different
medicine according to their therapeutic effect along with the Meridian Channel.
This phenomenon is being called meridian entry (channel tropism) by <WHO International
Standard Terminologies on Traditional Medicine in the Western Pacific Region
(2007; ISBN 978 92 9061 248 7) 6.1.32>, which is “orientation of the
medicinal action according to the meridian / channel on which the therapeutic
action is manifested, also called meridian tropism.”
4. Some
application studies in natural drugs
4.1. Phytomedicine Research in Germany
The <Phytomedicine Research in
Germany> is a very good article for understanding how the natural drugs do
works and how they were accepted by German society legally. It would be helpful
for understanding the therapeutic mechanism of Chinese drugs and promoting
their wider application.
“Abstract: In Germany since 1980,
more than 300 clinical studies have been carried out with standardized
phytopharmaceuticals, including Crataegus, Silybum, Ginkgo, Hypericum, Sabal,
Urtica, Kava-Kava, Allium sativum, Valeriana, Aesculus, Echinacea, and Viscum
drugs. These studies assessed the efficacy of phytopharmaceuticals for the
treatment of moderate or moderately severe diseases and prevention. Several
comparative clinical trials showed that these phytopharmaceuticals had full
therapeutic equivalence with chemotherapeutics and had the simultaneus
advantage of being devoid of any adverse effects. The mechanism of action of
herbal drugs and their extract preparations, which differ in many respects from
that of synthetic drugs or mono substances, can be characterized as a
polyvalent action and interpreted as additive or, in some cases, potentiating.
Currently, a rationale for the observed reversal effects and optimal effects
with very low doses after a long-term application has not been developed, but
is under investigation by systematic research at the molecular level.”
“In Germany, there are two
reasons phytopharmaceuticals are of high standard and are classified primarily
as conventional drugs by law. One reason is that during the last 50 years
traditional medicine has been kept alive by both medical practitioners and the
increasing interest of patients in herbal drugs. The other reason is that
shortly after World War II the pharmaceutical industry specialized in and
relied on herbal drugs and also developed and supported projects aimed at
optimizing the quality of herbal drugs by standardization and scientific basic
research. This development was paralleled by an intensified evaluation of
herbal drugs and a search for the active principles of
phytopreparations.”
“The fight for the acceptance and
registration of phytopharmaceuticals as drugs has been successful. Today in
Germany most of the herbal drugs, even mixtures of herbal drugs, are registered
as conventional drugs (1); this means that they meet the same stringent
criteria of quality, efficacy, and safety as synthetic drugs. These
requirements of the German drug law have stimulated the search for the active
principles in medicinal plants and phytopreparations, the development of
standardization methods of phytopreparations, and the performance of clinical
trials.”
“The search for the active
principles was an important prerequisite for the standardization procedure. In
contrast to investigations carried out 10 or 20 years ago, most extract
fractionations were performed using bioguided methods and the diode array
high-performance liquid chromatography (HPLC) technique (2,3). These techniques
may be quickly performed and allow researchers to focus on those fractions or
compounds that are expected to be responsible for the pharmacologic activity of
an herbal drug. Because of the use of new target models in pharmacology, there
has been remarkable progress in determining the mechanisms of action and the
true active constituents of herbal drugs. For example, the well-known antitumor
activity of garlic derives partly or totally from apoptosis induced by reactive
oxygen species via the transcription nuclear factor B of the tumor cell (4). In
another experiment, Dirsch et al. (5) revealed that allicin and ajoene, the
major constituents of fermented garlic extracts, inhibit the nitric
oxide-synthase of macrophages and, by this, the generation of NO species, which
in turn may be involved in the pathophysiology of atherosclerosis. In a new
approach to elucidate the antiprostatic active principle of the roots of Urtica
dioica (stinging nettle) root, we showed that one major constituent in the
water extract of this herbal drug, the Urtica lectin UDA (Urtica dioica
agglutinin), binds to the epidermal growth factor receptor of the prostatic
cell and thus inhibits prostate growth (6).”
“Further insights into the
mechanisms of action of herbal drugs have been obtained by novel bioguided
phytochemical investigations with Echinacea, Hypericum, and Crataegus drugs
(7-9). In many cases, the overall pharmacologic effects and therapeutic
efficacies derived not from a single compound but from several compounds
generating additive or synergistic pharmacologic effects. This means that the
standardization method to be applied should include at least two or more
compounds according to methods established by the national pharmacopoeias or
additional specific herbal drug monographs. Because the criteria for the
quality proof of an herbal drug differ from country to country, steps should be
taken toward a global harmonization of the guidelines, e.g., by the International
Federation of Pharmaceutical Manufacturers Association (IFPMA), which
represents the global research-based pharmaceutical industry and aims to ensure
the same standards of safety, quality, and efficacy for new medicines and more
efficient registration for use worldwide. These endeavors are handicapped when
the active principles are only partly known or when a mixed preparation
contains several raw drugs or extracts. In this case, a fingerprint
chromatogram of the extract or preparation obtained by HPLC, gas chromatography
(GC), or thin-layer chromatography (TLC) is the most appropriate way to
document the quality (3). This fingerprint should demonstrate identity and
purity of a drug and should guarantee the therapeutic equivalence of extracts from
the same herbal drug. Single marked constituents can be quantified. An exact
chemical characterization of all major constituents of an extract can only be
achieved by specific and selective analytical methods such as HPLC with diode
array detection, HPLC-mass spectrometry, or capillary GC with mass detector. If
a phytopreparation contains more than four or five drugs or extracts, it is
more reliable to characterize the individual drugs or extracts by HPLC before
mixing them. For publication and registration of phytomedicines in Germany, it
is mandatory that pharmacologic experiments be performed with at least two or
three batches of the phytopreparation from different time periods to confirm
reproducible processing and to guarantee stability and the same efficacy of the
preparation.”
“Before initiating a clinical
trial, all toxicity studies necessary to establish the safety of the trial must
be performed. From 1970 to 1985, the first phase of herbal drug investigations
in Germany was completed; this involved proving quality of these phytopreparations
and a thorough search for the various active principles. This phase was
followed by clinical trials that initially focused on about 10 herbal drugs or
phytopreparations which were already on the market, but for which sufficient
good clinical practice studies were lacking.”
The herbal drugs include
· Hawthorn
leaf with flower (Crataegus monogyna, C. laevigata)
· Garlic
(Allium sativum)
· Ginkgo
biloba leaf
· St.
John`s wort herb (Hypericum perforatum)
· Valeriana
root (Valeriana officinalis)
· Echinacea
purpurea herb
· Kava-Kava
root (Piper methysticum)
· Milk
thistle fruit (Silybum marianum)
· Saw
palmetto fruit (Serenoa repens)
· Nettle
root (Urtica dioica).
“One of the first clinical trials
was performed with hawthorn extract (Crataegus sp.), which was standardized on
flavonoids and procyanidins. It has been suggested that both classes of
compounds are the major active principles and are involved in the positive
inotropic and coronary artery-dilating effect described for Crataegus extract
(10,11). Meanwhile, an angiotensin-I-converting enzyme (ACE) -inhibiting effect
could be demonstrated for the oligomeric procyanidins (12). The results of the
trials were accepted by the German Drug Administration for the treatment of
nondigitalis -dependent patients with heart insufficiency stage I and II
according to the New York Heart Association. In a double-blind study of the
standardized Crataegus extract and captopril, the mean score values of
complaints recorded after 8 weeks of treatment showed the same degree of
improvement in both groups (13).”
“Other trials were performed with
the same positive results, e.g., with standardized Ginkgo, Hypericum (St.
John's wort), Kava-Kava, Sabal, Urtica, and Echinacea preparations (1).”
“Forty-four double-blind studies
indicate the efficacy of various Ginkgo extracts for the treatment of cognitive
disorders. Kleijnen and Knipschild (14) described eight of these studies and
determined that they were performed correctly and without methodologic
shortcomings. A recently published double-blind study performed with a Ginkgo
extract showed promising results when the extract was applied for the treatment
of dementia and, in particular, for Alzheimer disease (15).”
“The Hypericum extract, which is
now widely used for the treatment of moderate and less severe depression, was
investigated in several placebo-controlled double-blind studies (16). Some of
these studies were also performed in parallel with the synthetic
psychopharmaceuticals imipramine and maprotiline (17). Surprisingly, a 6-week
treatment with Hypericum extract with one of the synthetic drugs in parallel
resulted in the same significant reduction of the Hamilton Depression Anxiety
(HAMDA) score values, with the advantage that there were no side effects with
the Hypericum medication (17).”
“Another accepted use of herbal
drugs is for the treatment of benign prostatic hyperplasia. Germans spend approximately
250 million deutsche marks (wholesale price) per year on prostate remedies,
whereas in the United States, surgical treatment is the gold standard in
urology. In Germany, many urologists believe that treatment should not target
primarily benign prostatic hyperplasia as such, but only the associated
symptoms, especially the distressing symptoms of obstructive and irritative
urination (1). In the last 10 years, many clinical and pharmacologic studies
have confirmed the observations made when extracts of Urtica root, Serenoa
repens fruits (saw palmetto), Cucurbita pepo (pumpkin) seeds, and Hypoxis
rooperi were used to treat prostate symptoms (1). The Sabal, Cucurbita, and
Hypoxis drugs; sterins; and other lipids have been suggested to be responsible
for the antiinflammatory and cell proliferation-inhibiting effect of the
extracts. Similar positive effects observed with Urtica extracts may be caused
by a synergism of polar compounds such as UDA and polysaccharides (18). In
recent years, Echinacea preparations have developed into the best selling
herbal immunostimulants for the adjuvant therapy of recurrent infections of the
respiratory and urinary tracts and for the prevention and therapy of common
colds and flu (19). Thorough phytochemical investigations have revealed
cichoric acid, alkylamides, and polysaccharides to be the putative major active
principles responsible for the enhancement effect on the unspecific immune
system (7). Six clinical studies performed with Echinacea preparations,
reviewed by a meta-analysis, have confirmed the therapeutic efficacy, but
further investigations are necessary to find the optimal dosage and application
form (20). The list of herbal drugs that have been intensively investigated in
the last 10 years by phytochemists, pharmacologists, and clinicians includes
Silybum marianum (milk thistle), Allium sativum (garlic), Viscum album
(mistletoe), Piper methysticum (Kava-Kava), Harpagophytum procumbens, Aesculus
hippocastanum (horse chestnut), and Valeriana officinalis. Clinical studies
have been performed for these phytopreparations (1).”
“Other than the clinical proof of
efficacy, several new scientific findings have arisen from the many
pharmacologic and clinical investigations that have been performed with the
various phytopreparations. They provide insight to the mechanism of action of
herbal drugs, which in many respects differs from that of synthetic drugs. The
new findings can be summarized as follows: “
“Phytopreparations are applicable
primarily for the treatment of moderate or moderately severe diseases. This
limitation is often designated "for stage or grade I and II" of any
disease. In addition phytopreparations can also be used as adjuvants in
combination with a strongly acting chemosynthetic drug.”
“The positive clinical results
obtained with phytopreparations fully justify this type of
classification.”
“As shown in several comparative
clinical trials (21), several phytopreparations that were selected according to
the above criteria showed full therapeutic equivalence with chemotherapeutics
and had no adverse effects. “
“If one compares the
concentrations of the active compounds of an herbal drug with those of a
strongly acting chemotherapeutic drug, it is evident that most
phytopreparations exert their effects at a much lower concentration. The ratio
can be 1:10 or more. This difference can be explained by potentiating
synergistic effects caused by the various compounds in a raw herbal drug or
extract when no interactions between the several compounds are likely or when
interactions can be excluded on the basis of pharmacologic experiments. The
measurement of synergistic effects can be made with a two-component mixture of
substances according to the isobol method of Berenbaum (22), but it is not
applicable for herbal extracts. Therefore, an indirect method using the results
of clinical trials can be used: for example, if 1 g of a plant extract containing
a total amount of 1% bioactive compounds (approximately 10 mg) is found to be
therapeutically equivalent to approximately 100 mg of a synthetic substance at
a given equal indication (as evidenced in a clinical trial), the bioactive
compounds of the extract may possess polyvalent activities and exhibit a
synergistic (potentiating or overadditive) pharmacologic effect. This
conclusion is justified if the single components of the bioactive compounds
alone have very low pharmacologic activities. Furthermore, it must be concluded
that the activities of the single components are directed against different
pharmacologic targets. In this context, it should not be assumed that a 5- to
10-fold potentiation of an overall pharmacologic effect is caused only by an
increased solubility and by the enhanced oral uptake of the compounds of the
extract by the gut.”
“Another phenomenon observed for
many phytopreparations is dose-dependent pharmacologic or therapeutic reversal
effects if the same preparations are applied at high and very low doses. For
example, the cytostatically acting vincristine, which usually is applied in
vivo in milligram concentrations, can activate the nonspecific immune system in
minute (microgram or nanogram) quantities (23). “
“Many phytopreparations exhibit
no immediate pharmacologic or therapeutic effects and achieve their optimal
efficacy only after long-term treatment. This effect has been demonstrated in
an in vivo study with a Crataegus extract, which resulted in an increase in
myocardial blood circulation only after a 3-week application (24).”
“These new findings need a
scientific explanation, especially where the mechanisms of action and possible
interactions are concerned. There is a general consensus that these described
phenomena, which at present have no rationale, must be elucidated by thorough
and systematic research at a molecular level.”
Note: In above paper, that “Many
phytopreparations exhibit no immediate pharmacologic or therapeutic effects and
achieve their optimal efficacy only after long-term treatment” maybe caused by
following reasons:
Lack of potentiating synergistic
effects by adding more bioactive constituents from other drugs, just as the
principle of compound prescription of TCM.
Insufficient in drugs’ dose. Many
natural drugs are no poisons and dose-dependent, which allowing to be used in a
higher dose.
The therapeutic mechanism of the
natural drugs is regulatory rather than allopathic, so that the effect only
appeared after the overall physical condition being regulated back to normal.
This point is the main advantage of natural drugs.
4.2.
Multi-Factorial Cognitive Disorders
“Purpose: Multi-factorial
disorders of cognition such as Alzheimer's disease and vascular dementia are
increasing as the general population ages. The small number of drugs currently
approved for the treatment of such disorders provide palliative and temporary
benefit with only modest efficacy; thus, it stands to reason that alternative
approaches should be explored.”
“Method: Certain plants and plant
derivatives are currently under study for their effects on memory and other
domains of cognition. These plants and the compounds derived from them have
minimal adverse effects and have multi-functional properties (anti-oxidant,
pro-cholinergic, antiplatelet aggregation, amyloid beta peptide inhibiting)
with relevant application in the treatment of dementia and other cognitive
impairment. This paper reviews four herbal medicines (Ginkgo biloba, Bacopa
monniera, Huperzine Alpha, and Vinpocetine) with varying degrees of proven
benefit for the treatment of dementias and other cognitive impairment.”
“Results and Conclusions: These
herbal medicines are promising alternative or adjunct treatment modalities. The
plants or plant derivatives discussed here have, in many cases, proven to be
equally or more effective than conventional drug therapy in the treatment of
dementia.”
4.3.1. Therapeutic effects of
herbal extracts and constituents in animal models of psychiatric disorders
“A search for novel
pharmacotherapy from medicinal plants for psychiatric illnesses has progressed
significantly in the past decade. This is reflected in the large number of
herbal preparations for which psychotherapeutic potential has been evaluated in
a variety of animal models. The objective of this review is to provide an
overview of herbal extracts and constituents that have significant therapeutic
effects in animal models of psychiatric illnesses.”
“Eighty five individual herbs
reviewed were classified as anxiolytic, antidepressant, neuroleptic,
antidementia, or anti-substance abuse herbs. The full scientific name of each herb,
herbal part used, active constituent, extract, dose range and route, animal
model, possible mechanisms of action, and pertinent references are presented
via synoptic tables. The herbal mixtures were also mentioned. A considerable
number of herbal constituents whose behavioral effects and pharmacological
actions have been well characterized may be good candidates for further
investigations that may ultimately result in clinical use.”
“The investigation of a large
portion of the herbal extracts and herbal mixtures is in its infancy. Herbal
remedies that have demonstrable psychotherapeutic activities have provided a
potential to psychiatric pharmaceuticals and deserve increased attention in
future studies.”
4.3.2. A Review of Herbal
Medicines for Psychiatric Disorders
”OBJECTIVE: This review examines herbs commonly used for psychiatric
symptoms—St. John's wort, kava, ginkgo biloba, and valerian.
METHODS: MEDLINE was searched for
articles related to the use of herbs in psychiatry published after 1990. A
secondary search examined sources cited in articles obtained from the MEDLINE
search.”
“RESULTS: Of nine controlled and
standardized trials of St. John's wort, five showed the herb's superiority to
placebo, and four found no differences in effectiveness when compared with
antidepressant drugs. The pharmacologically active components are not known.
Several double-blind, placebo-controlled trials have demonstrated the
anxiolytic efficacy of kava, but these studies had ill-defined patient
populations, small sample sizes, and short treatment duration. All but one of
40 controlled trials of ginkgo extracts in the treatment of dementia found
clinically significant improvement in memory loss, concentration, fatigue,
anxiety, and depressed mood. Most studies of gingko had poorly defined patient
populations and small sample sizes and used nonstandard measures. A recent
well-designed multicenter study showed significantly less decline in cognitive
function among patients with dementia receiving gingko. Valerian has been shown
to decrease sleep latency and nocturnal awakenings and improve subjective sleep
quality, but placebo effects were marked in some studies, and in some cases the
beneficial effects were not seen until two to four weeks of therapy.”
“CONCLUSIONS: Although evidence
of the efficacy of herbal preparations in treating psychiatric conditions is
growing, translating the results of efficacy studies into effective treatments
for patients is hampered by the chemical complexity of the products, the lack
of standardization of commonly available preparations, and the paucity of
well-controlled studies.”
Nowadays everyone realized that
if they do not have a health body, he or she could not enjoy the colorful life.
People are paying much concern on health increasingly. Since Western drug’s
deadly inverse effects, more and more people are seeking hope from alternative
medicine.
Among the existing alternative
approaches, Chinese Medicine has been taking a dominant role because that only
it has an independent Medicine Theory with many therapeutic approaches and rich
in the resources of natural drugs. No doubt, that Chinese medicine will play
more and more important role in oncoming alternatives waves.
In many countries, CM market is
growing rapidly. The Cuba is the best one among them.
Cuba has been suffering
embargo for a long time and is lacking medical essentials, but they made a
miracle with their universal health care, and gained high reputations
worldwide, and were praised by some world’s authorities.
Learn from Cuba, said so of the World Bank.
Cuba, Colombia, Chile
and Costa Rica are the Latin American countries with the best health systems, said so of the WHO.
Dr. Luis Popa Salcedo has been working as a Cuban
Provincial Director of Public Health lasting 21 years, who commented that,
"Chinese Traditional Medicine was incorporated into our system as an
efficient and useful therapeutic tool. We use it because it works. As people
see its effects for chronic degenerative diseases, the demand is growing; and
it is not a high cost therapy. Our death rates have dropped for asthma,
diabetes, hypertension, cerebro- and cardiovascular diseases. Out of 140 doctors
in our province, 130 have been trained in acupuncture by the 36 physicians who
were already skilled specialists in this area."
The article《Cuba’s Green Revolution》has vividly described the herbal
medicine in Cuba.
David Picard also said in his
paper THE RISE of traditional
Chinese medicine, “Increasingly, companies are looking to TCM as a source of innovation.
The economic incentives are clear.”
November 06, 2006, reported that Swiss Novartis
AG announced plans for a US$100 million integrated research and development
center in Shanghai. “The company already
has a partnership with a local research institute, the Shanghai Institute of
Materia Medica, and collaborates with a local drug manufacturer,Wuxi PharmaTech
Co.”
In the western countries,
governments took strict regulations to control the medicine market. One of them
dictates that every constituent and its therapeutic effect must be clear for
the compound medicine. This is a big barrier for the Chinese drug since that of
even a single herb is a compound too, and the constituents were varied from
different producing area and even reaping season. So it is not easy to make
clear every constituent and their therapeutic effect exactly.
Due to the above problems, World
Health Organization (WHO), European Community (UC), United States (US), Canada
and many other countries have issued some Guidance or policies for promoting
the use of traditional medicine. They suggested that although the constituents
and therapeutic mechanism are not very clear in some traditional medicine,
since it has exact therapeutic effect and safe, which has been proven by long
time use clinically. These policies allow it to enter medicine market.
FDA accepted the idea
of traditional Chinese medicine idea
WHO -- Strategy for
Traditional Medicine 2002-2005.
E.C.----- DIRECTIVE 2004/24/EC
OF THE EUROPEAN PARLIAMENT AND OF THE COUNCIL amending, as regards
traditional herbal medicinal products, Directive 2001/83/EC on the Community
code relating to medicinal products for human use.
U.S. ----- Guidance for Industry Botanical Drug
Products.
Canada - About Natural
Health Product Regulation
Nowadays, the people doctor them self is increasing because of
searching medical knowledge easily on the Internet. We should make effort to
meet the needs of those people by substantially increasing the number of OTC
drugs. Thus, there will be a lot of benefits. For example, the patients can get
required drugs conveniently and thereby can alleviate the pressure of the
shortage in doctors. Also avoid that some patients can not get treatment on
time due to they dare not to see a doctor for some secret diseases, such as,
sexually transmitted disease, and mental diseases, etc.
Moreover, it is necessary to
increase the number of instant drugs for changing the way of drug
administration. For example: the instant sublingual drugs. As much as possible
to make the therapeutic constituents go directly into the systemic circulation
to reduce the harm for gut and liver by avoiding first-pass effect. It is not only to make the drug
take effect in minutes, but also will largely reduce the lost of therapeutic
effect of drugs and thereby being able to reduce the dose and the side effect.
Because the most diseases are
syndrome, although the main symptoms are same, however, the side symptoms may
be very different between the individual patients. The Chinese drug is used
differently according to the TCM theory, thereby it is difficult to make
Chinese drug in OTC. The most of TCM practitioner, whom only searches the
medical information from the old TCM books, would refuse to give a formula to
be used in OTC drugs, because that in TCM have no concept of pharmacological
and bioactive constituent at all. However, the modern pharmacological
researches on Chinese drugs have provided a good condition for this aims.
Suppose that make those modern research results integrating with the principle
of the compound prescription of TCM, we do certainly can make good natural OTC
drugs by the same materials from the Chinese drugs.
Also, we can make some natural
preparations to be used for preventative purpose. Who can prevent the heavy
onset of disease ahead by taking those preparations in case of feeling a slight
ill symptom?
On other hand, we can make some
natural OTC drugs as anti-aging purpose. We knew that increases with the age,
the organs and immune function of human body will be gradually degraded. We can
regularly eat some Chinese drugs to slow down the aging process.
I believe that natural health
products would become a part of daily diet with health enhancing purposes to
help us get free from many diseases in the near future.
The rocket of worldwide market
for Chinese drug is ready for launching. It only needs a gentle trigger.
Drug-mate is made by
natural Chinese drugs to be used with synthetic drugs together or to integrate
two kind drugs together directly.
The purpose is to reduce
the side effect and enhance the positive effect of synthetic drugs by the
advantage of overall improvement of Chinese drugs.
In this process, Chinese
drugs play a role to fix the damages caused by the side effect of synthetic
drugs to exert the both advantages of synthetic one taking the effect strong
and quick targeting on the diseases but with bad side effect and the natural
one taking the effect on general improvement quickly but targeting on diseases
slowly, thereby to improve the life quality of patients and shorten the
treatment duration.
More significant is that
those market-recalled synthetic drugs with serious side effects may be reused
again. The key is to control the safe duration when using, better to use them
as first aid. Thereby to increase the therapeutic available and reduce the
waste of huge cost on their development.
Recommended Reading:
Chinese Medicine on A H1N1 Flu 2009
Chinese Medicine and Cells Regeneration
Recover Mental Disorders by Chinese Medicine
Chinese Medicine on Wound Healing
Chinese Medicine can Reduce Stress
Chinese Medicine can Improve Sleep
Chinese Medicine and Sexual Function
Chinese Medicine and Heart Disease
Chinese Medicine and immune system
Chinese
Medicine - A Promising Therapeutic Approach-1
Daoism - The Philosophy of Traditional Chinese Medicine
8…The treatment of some chronic diseases by
Traditional Chinese Medicine
Sep
27, 2016, Health
minister vows to do more than just 'open the federal wallet' - CBC: Federal
Health Minister Jane Philpott says she has an obligation to do more than
"simply open up the federal wallet," as she negotiates a new health
care accord with the provinces. She is under pressure from the provinces and
territories to increase the annual general health transfer. Next year, the
annual increase in that federal envelope of money will drop to 3 per cent from
6 per cent.
In a
speech at Queen's University in Kingston, faced with the audience of medical
students and health policy experts, Jane Philpott said that: "Some
insist that the problem facing Canadian medicare is a lack of money, and they
decry the fact that the future growth rate of the Canada Health Transfer will
be brought more in line with the growth rate of our economy,"
Philpott
said the facts do not support the idea that what the health system needs most
is more cash.
"I'm
convinced that we have an obligation as a government of Canada, for example, to
do more than simply open up the federal wallet."
She
said the federal government is committed to giving the provinces more money,
but "we must ensure that new money doesn't simply inflate health systems,
but helps to put health care on the road to long-term sustainability."
Philpott
said that means driving innovation and making the health care system better.
In a
40-minute speech, Philpott highlighted a number of areas she believes need
improvement, from home care and mental health, to e-health records.
She
said "Patients with severe mental illness often face long waits to get
access to specialists. Others who require counseling or therapy may have
private insurance coverage, but most have to pay out-of-pocket, or more
often, try to manage without.”
In
viewing that Mental illness costs Canadian economy $50 billion per year,
we should develop a cheaper and easy alternative therapy.
In
which regard, the botanical OTC drugs based on the Traditional Chinese Medicine
will play a leading role.
8.1…Natural
Medicine based on the theory of Traditional Chinese Medicine
Western
Medicine (WM) takes Reductionism
as philosophical guidance in viewing human body as the assembly of non - living
parts.
The
philosophical limitation has misled WM into plight in treating diseases no
matter in Communicable or Non-communicable,
such as, AIDS, super-bugs and Cancer. As
seeking new way out, WM has to develop toward Holistic approach with the
development of System
Biology and Evidence-Based
Medicine, which means that philosophy of WM is turning toward Holism from Reductionism.
The Holism is similar as Daoism
– a Philosophy has been conducting Traditional
Chinese Medicine (TCM) for thousands of years.
June 16 2013, in article Daoism
- The Philosophy of Traditional Chinese Medicine, I indicate that
Daoism
views everything in the world is the unity of opposites, both sides are in the state
of the opposite and unity with self-dynamic equilibrium.
As
similar way, it views human body as an organic whole that all components are
closely interacted in the state of self-dynamic equilibrium. A well-balanced
human body will form an effective self-defense system that can handle the most
of pathogenic agents. So that the treatments of TCM do not directly target on
pathogenic but to bring back the natural balance – the balance of Yin and Yang.
In
past thousands years, TCM has identified about 11,146 plants, 1581 animals and
80 minerals as medicinal use, and accumulated about 100 thousands of
experience-based formulas, which covering almost all known diseases. By the
methods of modern biopharmaceutical technology of Western Medicine, based on
the experience-based formulas, China’s scientists have developed many OCT drugs
in the forms of injections and tablets.
Modern
studies from the level of molecular, protein and gene found Chinese natural
drugs containing a wide range of bioactive constituents. Some of them have
therapeutic effect that is similar to that of synthetic ones in killing the
pathogenic agents directly, and some of them have nutritional effect that is
similar to that of Orthomolecular Medicine
coined by Linus Pauling
who was two times Nobel Laureates. For ill-weak patients, nutrition is even
more important than that of drugs. I think that this is the unique advantages
of natural drugs, and also it is the unique advantages of TCM.
Some
of Chinese drugs can improve human immunity by boosting the weight gains of
immune organs, increasing the number and activity of the phagocytes, NK cells and
so on. Therefore, in subjective viewing, TCM is to regulate the physical Yin-Yang balance, but in
objective actual, the process of the regulations plays a role of improving the
immune function, then the pathogenic agents to be killed by enhanced immune
system.
The
significant one of the characteristics of TCM is the compound formula, i.e.,
for the same patient, one time drug dose with a variety of different medicines
(botanicals). This way can play a synergistic effect, which is to enhance the
therapeutic effect with offsetting side-effects of each other.
For
the botanicals, minerals and others that TCM have been used, any of them is the
compound in ingredients. They coexist of a variety of Chemical element and
substance molecular.
The
research report Plant
Nutrient 'Cocktail' Kills Breast Cancer Cells indicates the researchers
tested six known protective chemical nutrients from turmeric, soybeans,
broccoli, grapes and tea. Individually, they were ineffective against cancer.
But combined, they suppressed breast cancer cell growth in the lab by more than
80 percent, and eventually triggered the process leading to cell death.
The
researcher Dr. Madhwa Raj points out that all the ingredients in the cocktail
come from foods people eat every day, but at much higher levels than they could
possibly get from their diet. He has established a bio-tech start-up company to
bring the super-cocktail to market as a nutritional supplement for breast
health, which does not require approval from the Food and Drug Administration -
FDA.
The
report provides us two facts:
1. A
Modern scientific proof for the correctness of Ancient unscientific compound
formula of TCM. We may say that Modern Western civilization proved the wisdom
of Ancient Eastern civilization.
2.
The nutritional supplement does not require approval from the FDA - the world's
No.1 authority in medical regulation. It means that for the natural medicinal
beverages with no market barrier legally.
Other
advantage is the natural OTC drugs and Medical-Functional Beverage are all in
line with the global trend that is of the new health conscious of the people
with new understanding for health and paying more attention on the
health-keeping with diseases-preventing in advance.
The
inadequate healthcare resources and deadly side effect of Western Medicine are
pushing people to seek medical alternatives with producing new demands with
shaping new market.
From
above, we may clearly understand that health functional products based on the
materials of natural botanicals under the guidance of the theory of TCM will be
welcomed and profitable in broader market.
8.2…The mental disorders are caused by brain
atrophy
Health
Minister Jane Philpott appeals that "Patients with severe mental
illness often face long waits to get access to specialists. Others who require
counseling or therapy may have private insurance coverage, but most have
to pay out-of-pocket, or more often, try to manage without."
It is
significant that find out an effective and cheaper treatment approach that will
be affordable by paying out-of-pocket.
July
29, 2012, in article Recover Mental Disorders by Chinese Medicine, I indicate
that:
Recent
years, scientists have learnt more clearly about human brain structure and work
mechanism. Our brain is an extraordinarily complex organ that is made up of
many different structures. More evidences have showed that various mental
disorders are connected with abnormality or atrophy in brain. For instance:
Depression – Neuroimaging studies have
shown abnormalities in regions of the medial and the lateral
prefrontal cortex, the limbic system and basal ganglia.” “Apparent shrinkage of a part of the temporal lobe called the
hippocampus, which is critical for memory”. Identified neurophysiological abnormalities in multiple areas of
the prefrontal cortex (PFC), the amygdala, and related parts of the striatum
and thalamus.
Schizophrenia - Many researches have made clear that
heavy atrophy has occurred in the brain of psychotics. The best research job
did by Paul M. Thompson’s team In University of California,
Los Angeles (UCLA). Over a span of five-years, they did MRI scans for the
brains of 12 teenagers diagnosed with schizophrenia and 12 mental healthy
teens. They found that even those who took anti-psychotic medicine, the loss of
gray matter with schizophrenia was much greater than that of healthy teens.
Patients with chronic schizophrenia displayed bilateral hippocampal volume reduction. Patients with
first-episode schizophrenia but not schizophreniform psychosis displayed left
hippocampal volume reduction. The patients with schizophrenia had less activation of the right dorsolateral and anterior
prefrontal cortex, right anterior cingulate, and left lateral temporal cortex
during word encoding, compared with the healthy comparison subjects.
Researchers
have made clear that the schizophrenia is a brain disease activated by stress.
Professor Robin Murray, a leading psychiatrist, Institute of
Psychiatry, University of London, said: “That the environmental components are biological, migration
and social adversity seem also to contribute to the incidence of schizophrenia.
That people who live in cities have a higher incidence than people who live in
the country, and that migrant has a much higher incidence. Such as in UK
Caribbean migrants have an incidence at least six times that of the host white
population.”
Here
was powerful evidence that brain disease was activated by stress, it was that
one of twins was onset of Schizophrenia and other one was in health.
Institute of
Psychiatry, University of London has been tracking 160 identical twins. Among
them, Sean was ill and his older brother Stephen kept in health, both showed in
a documentary of US Discovery Channel, namely Schizophrenia Stolen Lives
Stolen Minds.
They
had enjoyed their happy boyhood together. Sean’s talent had let him enter an
England top art school. At 20, he was designing an award winning logo for a
prestige Graphics Design Company in London, Britain. It was schizophrenia that
made his mind and his life collapsed.
For
being identical twins, Sean and Stephen have same Gene and brain. However, only
Sean was ill. So it must have some difference between the brothers
non-physically. We can easily find the difference from Sean’s talks. That was
the challenging job that gave Sean stress, such as task deadline. This is the
main source of the psychological stress and the possible psychotic inducement
for Sean’s ill.
Many
cases have showed that the most psychotic sufferers are the genius youth. And
many creative geniuses are the sufferers of bipolar on a
historical view. So that some people questioned that: Is Bipolar The Root Of Genius.
In as
much as the most of psychotics are the gifted youth and stress played an
important role on their pathogenesis, we should seek the psychotic inducement
from the differences between the genius brain and normal brain.
The
obvious difference is the thinking speed between the genius brain and the
normal brain. The first one is much faster than that of second one. It just
likes the work efficiency of the CPU in computer, that the Intel 80686 is much
faster than the Intel 80286 when processing the same tasks.
Everything
has two sides, while the gifted kids enjoy their talent and outstanding, they
were also threatened by the potential negative effect, which is under the same
psychological stress that the negative impact is stronger for them than that of
normal one, and the impairment on brain is heavier for them than that of the
normal one. These may damage the normal way of the brain's thinking and cause
mental disorders.
On
other hand, the untalented youth are rare to take challenging tasks; therefore,
they have lesser chance to suffer heavy psychological stress.
Sean
said, if he does not take the medicine he might be locked. He strongly hopes to
return to normal. His older brother Stephen’s life was affected deeply, too. He
has lost his job at the time when Sean’s starting onset of schizophrenia and
has been accompanying ill Sean. Stephen worried very much about that he has
high chance to get the same illness as his younger brother’s.
They
are the common representative for the psychotic sufferers and families. We
should help them get out of the sad situation as soon as possible.
Antipsychotic
Drugs: currently the dominant antipsychotic approaches are the atypical
antipsychotic drugs. The best one is Zyprexa. It mediates through a combination
of dopamine and serotonin type 2 (5HT2) antagonism to control the symptom such
as hallucination, acousma, and mania effectively. However, it cannot control
the brain atrophy continuously. Make the most patients keep in
sleepy, emotionless and behavior abnormally. So the patients cannot go back to
society.
Also
it has some heavy side effects, such as cerebrovascular adverse events, hyperglycemia and diabetes
mellitus, neuroleptic malignant syndrome, tardive dyskinesia, hemodynamic
effects, heart attack and so on.
Orthomolecular medicine: it conceptualized by
double Nobel laureate, Linus Pauling in his paper Orthomolecular Psychiatry of 1967. That is the
practice of optimizing health and treating disease by providing correct amounts
of vitamins, minerals, amino acids, enzymes, essential fatty acids and other
substances which are natural to the body’s environment.
In the early 20th century, some doctors hypothesized that
vitamins could cure disease, and supplements were prescribed by
megadoses in the 1930s. In the early 1950s, a few psychiatrists began adding massive doses of nutrients to
their treatment of severe mental problems. The original substance was vitamin
B3 (nicotinic acid or nicotinamide), and the therapy was termed
"megavitamin therapy." Later the treatment regimen was expanded to
include other vitamins, minerals, hormones, and diets, any of which may be
combined with conventional drug therapy and electroshock treatments. A few
hundred physicians now use this approach to treat a variety of conditions, both
mental and physical.
Nowadays,
the Vitamins, Minerals and other dietary supplements are easy to buy from shops
or pharmacies that are locating anywhere world widely. It showed the success of
Orthomolecular Medicine.
8.3…A psychotic with 10 years in illness cured
by Chinese drugs
8.3.1…The symptoms before and after treatment
A
Chinese male in his 35, onset schizophrenia at 17, cured in a short time.
After
finishing 2 years high school, 4 years university and 2 years works, he
recrudesced and lived in the nursing home for about 10 years. Maintained by 20
mg Zyprexa and slept 15-16 hours daily. Sometimes he went out, did not come
back.
April
2003, in a grocery store in Toronto, I met him and his father.
At
that time, his father has taken him out of nursing home for a couple of months,
since the father has retired. When I said something to the son, he was scared
with "no, no" in mandarin and went backward. I was surprised by his
response and stared at the father with wondering.
The
father introduced some symptoms of his son in despair: don’t laugh, don’t cry,
don’t watch TV, don’t listen to music, don’t take a bath and don’t brush teeth
-- do nothing beside eating and sleeping. He worried that nobody would take
care of his son after his leaving this world.
I
told the father that Chinese drug (natural herbal preparation) can help his
son, and I can prepare and donate this kind of drug. The father accepted my
advice with suspected expression.
I
knew that he was not fully confident of my drug, because he did not found any
recovered case by constantly information searching. However, he knew that
Chinese drug is safe and also he has been tormented by desperation for his
son’s treatment. He was just like a person in deep water hoping rescue -- even
a piece of floating straw would be taken as a life-saving hope.
I
supervised the father daily by telephone. In the first 2 days, the son slept
heavier, increased nearly 2 hours than that of before, and then decreased day
by day, after a week, slept 10-11 hours daily. The surprising is that his
emotion came back again after taking my drug only several days. He showed
himself as a normal person. Talk, laugh, watch TV, listen to music, and do some
housework willingly.
About
1 month later, the father phoned me with happiness: "your drug is
wonderful, recently my son always ask me the meaning of English words those he
saw on the tools or on the wall along street." His son could search
English words meaning by electronic dictionary installed on computer, which he
showed his son how to use once only. More surprising was that his son knew more
English words than those of he ever told. His son has recalled some English
words that he had studied in high school and university. The father also asked
me to help him, because his son wanted to open the computer to see inside.
For a
trial, I suggested sending him for shopping vegetable and fruits, meanwhile, to
check some item's price. He did successfully.
After
2 months, the son wanted to know more new things eagerly. The father was bored
by son's endless questions. I suggested that send his son to study English in
school. The purpose was for further therapy psychologically from contacting
other people. Meanwhile that will improve his communicating ability in English
and prepare to get his life back on track in society to enjoy his young life.
He had his son registered in English school.
At
first 2 weeks, the father accompanied his son to go to school, and then
the son went to school alone every day happily.
In
addition, on my request, the father had his son's blood tested and the results
were good, also lowered the dose of Zyprexa from 20mg to 15mg daily. I think
that Zyprexa should be decreased gradually, otherwise may harm the son’s
health.
8.3.2…The therapeutic mechanism analysis
Although
no one checked the son's brain until now, but his behavior has told us that his
brain was atrophied before and was restored after taking herbal medicine. So
his behavior improved from abnormal to normal, from inactive to active, from
doing nothing to doing some housework and studying English in school.
If we
could scan his brain by MRI, we would see the brain growth day by day. Dream
came true. A miracle was created.
Now
many researchers found that human’s nerve cell could regenerate in certain circumstances.
Powerful
evidence is Terry Wallis, who has been in coma since a car
accident in 1984, has regained consciousness and cognitive abilities such as
his speech in 2003. By MRI scans on Wallis's brain over a span of 18 months,
found growth of new neural processes in the part of the brain that controls
movement.
Chinese
medicine improved the psychotic symptom in short time, showed it has strong
therapeutic effect for the regeneration of brain cell and make atrophied brain
being restored quickly.
In
above herbal preparation, every component was used for a long time in China.
Some were last hundreds years, some even thousands years. No side effects were
reported. It is safe not only in dose (large or small) but also in taking term
(longer or shorter), which was proven by the researches of modern
pharmacological and long time massive application clinically.
Compound
preparation with dozens of Chinese drugs can reduce the negative effects of
psychological stress largely, because it can alleviate the stress symptoms by
releasing endorphins, decreasing the stress hormone cortisol, eliminating the
oxygen free radicals, lowering the blood pressure, reducing the heart rate,
relaxing the muscle tissue, improving the digestion, improving the sleep and
relieving the psychotic symptoms. More important is that it can take the
vasodilator effect to improve the macro- and micro-circulation, and thereby
accelerate the restoration of the atrophied brain by enhanced supply of oxygen
and nutrition.
Chinese
drugs can relieve the side effects of anti-psychotic drugs. Improve the
medication compliance, life quality, and help patients recover early.
Chinese
drugs are not only having the all ingredients of the Orthomolecular medicine
also having many unique medicinal constituents that are similar to the Western
drugs in therapeutic effect with lesser side effect.
Psychotic
is a disease that is sensitive to the psychological stress, some can recover
without therapy when the psychological stress was relieved and some can recover
by taking placebo. So it is hard to say the effect of any drug. I think that
the best way to examine a drug whether effective is to treat a patient who is
in the psychotic symptom at least more than one year and mental retarded, just
like above young man that have lasted 10 years in psychotic status. It is long
enough for proving the positive effect of Chinese drug.
The
misfortune is that the most of psychotic are gifted youth. We can imagine how
their parents were struck psychologically when their beloved children were
diagnosed as psychotic. Their child was fostered by a lot of effort with
putting a lots hope that parents were unable realized. But now, their
beloved-kid is just like when a baby bird’s outspreading its wing toward the
immense air, the wings were suddenly broken helplessly. Also just like a bud
protruded its head against the soil barely, was struck by hailstone storm. For
a family it is the most tragic experience.
In
fact, among the fruits of human civilization that we have been enjoying, some
were invented by psychotic brains. Chinese medicine can restore the damaged
genius’ brains and make them continue to exert their talent. It will be a great
contribution to the development of human civilization.
The
above case is an example that demonstrated the amazing therapeutic effect of
Chinese drug, which also demonstrated that I’m proficient in using Chinese
drug. Although it is only one case, however the young man was in psychotic
lasting ten years, and had heavy retarded mentally. His specific situation is
sufficient enough to rule out the possibility of any other therapeutic factors
besides Chinese drug.
I
have strong confidence to help more psychotics recover as well as before by
Chinese drug, and send the happiness back to their families. Also I can clone
the case to other diseases, with changing ingredients of compound preparation
according to patient’s specific symptoms.
8.3.3…My
confidence to help more psychotics
My
confidence to help more psychotics based on following condition
A.
I’ve learnt more about Chinese medicine associated with various diseases, which
came from more than 37 years studying constantly. I have accumulated nearly 4
Gb data related with TCM, include royal court secret recipe, patent documents,
clinical trial papers that published on professional magazine and some new
research results in modern biochemistry.
B.
For each Chinese drug to be used, I’ve made clear their bioactive constituents,
positive effect, negative effect and integrating effect when they were used
together. Most above information cannot be gotten from traditional books in
TCM, but can only get from new research results with modern biochemical and
pharmacological means. Also this is why the old practitioners in TCM could not
treat disease quickly and accurately. Even for a general illness that the
prescription needs to be adjusted from time to time.
C.
Take the advantages of compound prescription of TCM, treat patient on different
symptom at the same time by putting different Chinese drug together to enhance
each other’s therapeutic effects, eliminate each other’s side effects.
D.
Chinese drug can supply some essential nutrients for patients. The vitamins and
minerals are important nutrients, especially for patients whose digestion
ability was lowered by suffering illness.
8.4…To
rescue depression by Traditional Chinese Medicine
8.4.1…The harsh reality that Canada is suffering in
diseases of depression
Sept. 1, 2016, report Unmet
Mental Health Care Needs Costing Canadian Economy Billions said that:
Depression and anxiety cost the Canadian economy at least $32.3 billion a
year and $17.3 billion a year, respectively, in foregone GDP due to lost
productivity, according to a new report
from The Conference Board of Canada’s Canadian Alliance
for Sustainable Health Care.
“A
large proportion of working Canadians have unmet mental health care needs that
prevent them from performing to their utmost and our report shows this has
serious consequences for the Canadian economy,” said Louis Thériault,
Vice-President, Public Policy, The Conference Board of Canada. “Improving
treatment of mental illness among working Canadians would offer significant
benefits for individuals, businesses, society and the economy.”
Depression
and anxiety cost the Canadian economy at least $32.3 billion a year and
$17.3 billion a year, respectively.
A
large proportion of working Canadians have unmet mental health care needs that
prevent them from working full-time or part-time.
Almost
a quarter of Canadians living with a mental illness are unable to work because
of their symptoms.
Employers
can improve the treatment of anxiety and/or depression among employed Canadians
by facilitating access to evidence-based benefits, programs and supports.
In
Canada, it is estimated that mental illness can affect workplace functioning.
If all employees living with depression/anxiety had access to better treatments
and supports, then workplace functioning would improve significantly. Mental
illness can also prevent some people from entering the workforce. If all these
Canadians had access to better treatments and supports, the economy may see up
to 352,000 Canadians with depression/anxiety enter the workforce as fully
functional employees each year until 2035. Taken together, this could
potentially boost Canada’s economy by up to $32.3 billion a year from
improved treatment of depression and $17.3 billion a year from anxiety
treatment.
Employees
in services-producing industries feel they have the greatest need for mental
health care. About 2.5 million employees in the services sector feel some
sort of mental health care is required. Industries that have the highest
proportion of employees with unmet mental health needs, include:
administrative
support and waste management (44.4 per cent)
accommodation
and food services (43.8 per cent); and
professional,
and scientific and technical services (42.9 per cent).
Organizations
can improve the treatment of anxiety and/or depression among employed Canadians
by facilitating access to evidence-based benefits, programs and supports.
Improved prevention strategies, both for new and recurrent onset of mental
illness are also needed, along with effective return to work programs.
Healthy
Brains At Work: Estimating the Impact of Workplace Mental Health Benefits and
Programs is the third of a four-part series that explores the importance of
addressing mental health and mental illnesses in Canadian workplaces.
This
research was made possible through the financial support of Lundbeck Canada,
Sun Life Financial, SCM Health Solutions, The Mental Health Commission of
Canada, the Canadian Depression Research and Intervention Network, the Mood
Disorders Society of Canada and The Conference Board of Canada’s Canadian
Alliance for Sustainable Health Care (CASHC).
Sept. 1, 2016, article Depression,
Anxiety Cost Canadian Economy Almost $50 Billion Per Year reports that: Improving the treatment
of depression and anxiety could boost the economy by nearly $50 billion per
year, the Conference Board of Canada said in a report released Thursday. The report said that almost 25 per cent
of Canadians living with mental illness can't work due to their symptoms.
The Conference Board had numerous suggestions for improving
workers' mental health.
They included providing employer-sponsored benefits such as
coverage for prescription drugs, Employee Assistance Programs (EAP), as well as
paramedical services.
By contrast, the cost of keeping the status quo could be a big
one.
If mental health keeps being treated the way it is now, the
number of workers with a mental illness could grow from 1,020,500 in 2012 to
1,337,800 in 2035.
This is hardly the first study to examine the cost of mental
health going untreated in the workplace.
The U.S. Centers for Disease Control estimates that depression
can lead to as many as five missed work days and 11.5 days of lower productivity every three months for
a single employee.
In total, it can cost the U.S. as many as 200 million workdays
per year and $17 to $44 billion in productivity.
All the more reason to take mental health seriously.
8.4.2…The magic effect of Chinese
Medicine on depression
July
29, 2012, in article Chinese Medicine can Reduce Stress, I indicate that:
Chinese drugs can reduce the negative effects of psychological stress largely
by alleviating the stress symptoms by releasing endorphins, decreasing the
stress hormone cortisol, eliminating the oxygen free radicals, lowering the
blood pressure, reducing the heart rate, relaxing the muscle tissue, improving
the digestion and sleeping, and bringing more fresh oxygen to body tissues by
improving the circulation of blood and lymphatic fluids. This increased blood
flow will eliminate the waste products from inside the body and enhance the
nutrition supply to take an anti-aging effect.
Dec.
22, 2011, in the article Chinese Medicine and Cells Regeneration, I introduced that:
"Clinical
practices have been demonstrating that Chinese medicine is superior to Western
medicine in the treatment and prevention of brain disorders. Chinese Medicine
can directly permeate through the blood-brain barrier into the brain to take
the therapeutic effect in improving the state of hypoxic ischemic and
metabolism. It will not only promote development of immature neurons, but also
to repair the damaged nerve cells. Enhance the activity of nerve cells and
restore the injured brain. Such as, Chinese medicines have very good
therapeutic effect on the congenital cerebral palsy, sequela of cerebrovascular
disease and traumatic brain injury as well as Alzheimer’s disease, etc."
"Chinese
medicine contains various natural nutrients that are easily absorbed by our
body, such as, amino acids, peptides, phospholipids and so on. So the treatment
in Chinese medicine is able to generate magical effect that simply can not get
in the treatment of medication or surgery in Western medicine. Chinese medicine
is a kind of restorative treatment in the level of cell and gene, through
providing nutrients for the damaged nerve cells, to promote residual neurons
regeneration. Therefore the damaged function of the nerve system will be
restored."
Promotion
of nerve cell’s differentiation and development
"In
vitro, vivo and clinical trials in the conditions of normal, hypoxic and
glutamate damage, shows that Chinese medicine can increase cells’ activity,
promote nerve cell’s differentiation and development. Inhibit the apoptosis of
nerve cells in the earlier, middle and later stage, which induced by hypoxic
and glutamate damage."
Promotion
of neuronal growth
"Neonatal
rat’s dorsal root ganglia in serum-free culture, for the test group add the
Chinese medicine in basic culture medium, control group add nothing. In the
test group, the length of dorsal root ganglion cells neurites are (314 ± 43)
μm. It is significantly larger than that of (76 ± 26) μm in control group.
These results indicate that, in vitro, Chinese medicine can promote the growth
of dorsal root ganglia and cerebral cortex neurons."
Activation
of undifferentiated stem cells
"In
the central nervous system, there are some undifferentiated stem cells. Chinese
medicine possesses the ability to activate those stem cells to split and
regenerate new cells. So that make the nerve cells be restored to normal levels
from original absolutely decreased status."
"Ischemic
injured Brain, after 7 days’ treatment of Chinese medicine, in ischemic injured
area, found a great number of nestin expressions, this shows that Chinese
medicine possesses a strong ability to promote the proliferation of adult
neural stem cells in vivo.
The
Experiments also observed that the functional recovery of patients’ limb is
sync with the increase of nestin level. The results proved that the Chinese
medicine can effectively promote the nestin expression. Therefore contribute to
rebuild nerve tissue effectively after cerebral ischemia damage."
8.5…To
cure Dementia by Traditional Chinese Medicine
According
to National
dementia research and prevention plan of the government of Canada, “the
dementia is the loss of mental functions as a result of cell loss and
connections in the brain breaking down over time, also called
"neuro-degeneration." The symptoms can include: 1.The memory loss. 2.
Impaired judgment and reasoning. 3.Changes in behavior, mood and communication
capacities.”
“As
dementia progresses, a person's ability to function diminishes and reaches a
point where the patient becomes totally incapacitated.”
“There
are many types of dementia, Alzheimer's disease being the most common type.
Other forms of dementia include vascular dementia (when the brain cells are
deprived of oxygen), Lewy body dementia (when abnormal deposits of the
alpha-synuclein protein are found in the brain's nerve cells), frontotemporal
dementia (a rare disorder that can occur at any age and affect the frontal and
temporal loss of the brain), and dementia due to HIV, among others.”
According
to Prevalence and Monetary Costs of Dementia in Canada: A Report
by the Alzheimer Society of Canada (2016), “based on projections using the
Canadian Study of Health and Aging (1994) data, as of 2016, there are an
estimated 564,000 Canadians living with dementia. By 2031, this number is
expected to rise to 937,000, an increase of 66 per cent. Of the current number
of Canadians with dementia, more than 65 per cent are women.”
“According
to the National Population Health Study of Neurological Conditions (2014), the
combined health-care system costs and out-of-pocket caregiver costs amounted to
$10.4 billion in 2016. By 2031, this figure is expected to increase by 60 per
cent, to $16.6 billion.”
“Generally,
costs for people with dementia are estimated to be five-and-half times greater
than for those who do not have the disease. Home care and long-term care are
the largest contributors to direct costs. In 2011, family caregivers provided 19.2
million unpaid hours of care. This number is projected to double by 2031.”
Modern study shows that Chinese
medicine can help to treat dementia.
On
the website of Pacific College of
Oriental Medicine of the United States, there an article Traditional
Chinese Medicine and Dementia said that: “Traditional Chinese medicine can
help to treat a variety of the discomforts associated with Dementia. From
acupuncture to herbal remedies, Chinese medicine practitioners have provided
treatments for many of these situations for over two thousand years.”
Dec.
9, 2016, Baiyunshan
Compound Salvia Research Center published research result of Prevention and
Treatment of Alzheimer's disease.
7
years’ clinical trials proved that Compound Danshen tablets has a positive
therapeutic effect in the treatment of vascular dementia and senile dementia.
Studies have shown that botanical salvia miltiorrhiza can effectively improve
the cognitive function of senile dementia animals. Studies have shown that
earlier prevention and treatment for the early onset of senile dementia seems
to be more effective measures. They suggest that susceptible people should take
compound Danshen tablets as early intervention of Alzheimer's disease.
Oct.
23, 2016, a report in Mandarin said that a team led by Professor Liang
Jing at Department of Molecular and Medical Pharmacology of UCLA found that
botanical Hovenia Dulcis has effect in treating hangovers of alcoholism and
Alzheimer’s disease.
They
did two sets of experiments, using mice to simulate human alcoholism and drink
syndrome. In the first group, let the mouse "drink into" a certain
amount of alcohol in equivalent to drink 10 to 15 cans of beer in two hours,
they immediately lost consciousness and physiological reflexes. After an hour,
they gradually return to normal. However, when those mice received Hovenia
Dulcis, the sensory and physiological reflexes recovered in about 15 minutes.
They
also did a second set of experiments to test the effect of Hovenia Dulcis on alcohol
addiction. They were pleasantly surprised to find that after taking Hovenia
Dulcis, though those rats has been constantly drinking, but, there were no
longer produce alcohol dependence.
The
pharmacological principle is that through the nature of plasticity of nerve
GABA receptor of brain inhibitory system, alcohol changes or reduces the
function of the brain inhibitory regulatory system, known as toxic effects of
alcohol. Hovenia Dulcis can reduce the toxic effects of alcohol on the
receptor.
More
amazing was the long-live promoting effect of Hovenia Dulcis.
In
the experiment, Liang Jing team used two-year-old rats that were usually only 3
years of life span. However, after taking Hovenia Dulcis, the mice actually
lived to 4 years old and still was in energetic without sign of the nature old
was approaching.
With
occupational sensitivity and understanding of the intrinsic link of nervous
system, Liang Jing judged that Hovenia Dulcis should play a role in function of
aging brain and even in disorders of senile brain.
Thus,
Liang Jing eyes put on a chronic human disease: Alzheimer's disease.
At
present, due to there is no positive effect drugs clinically in treatment of
Alzheimer's disease, so it is considered to be non-preventable and cannot be
cured. The sufferer of Alzheimer's disease can only "wait for death."
In 2015, in the United States, the Alzheimer's disease patients estimated 5.3
million, of which 5.1 million is over 65 years old, while the global data is
estimated at more than 44 million.
At present,
the United States and other countries are launching a war to overcome
Alzheimer's disease. By 2012, more than a thousand agencies have completed or
are conducting clinical trials for Alzheimer's drugs. However, none of the
trials have showed any clear evidence that these drugs would have delayed
Alzheimer's disease, not to mention that reversed. It can be said that at
present, the drug for effectively treatment of Alzheimer's disease is zero.
There
is a protein in the brain that supports and establishes connections between
neurons, known as the support protein - Gephyrin. The function of the support
protein is like an information network. Liang Jing team firstly discovered a
key pathological change in Alzheimer's disease, that amount of support protein
reduced to less than 50 percent of normal volume. The normal human brain is
like a big tree with luxuriant foliage. But the Alzheimer's patients, their
brain is like dead branches. The original green leaf-like nerve connection
became intermittent spots-like, looks like a pot of porridge.
The
experiment was using test rats with Alzheimer's disease, the Hovenia Dulcis
once again shows the therapeutic magic. The support protein in the brains of
Alzheimer's disease gradually recovered to the normal level with the
prolongation of administration time, and the recovery of nerve connection was
accompanied by remarkable recovery of memory, cognitive ability and learning
ability.
From
the comparison of mouse brain slice photograph can clearly see that
precipitation of amyloid protein in the brain was also obviously reduced. The
slices of sick rats were gray, but, the slices were as fresh as healthy of the
rats that have taken Hovenia Dulcis. Prof. Liang Jing said: "the function
of Hovenia dulcis was equivalent to the scavenger, removed the dirt of brain
and repaired its nervous system.
They
developed a new product - SmartoOne as a dietary supplement, and obtained the
FDA's permission. The initial results are encouraging, some patients have
reversed the disease, and the intelligence test scores have improved. The
patients regained ability for self drinking and eating. Cognitive ability was
improved, such as that before cannot be completed narrative sentence, now can
be completed. The symptoms in anxiety and mental onset also decreased.
They
completed pathology studies and are still in pre-Clinic.
8.6…Chinese Medicine can Improve Sleep
This is the reedited-excerpt of my
Dec. 21 2011 article Chinese Medicine can Improve Sleep.
Sep
15, 1989, the research Epidemiologic study of sleep
disturbances and psychiatric disorders: an opportunity for prevention?
Reported that:
Sleep disturbances have been linked to
psychiatric illness, sleep apnea (arrested breathing while sleeping), emotional
stress, cardiovascular disease, and even increased mortality. This study
focused on the relationship between sleep disturbances and psychiatric
disorders, because it was hypothesized that difficulty sleeping may be an early
symptom of or conversely a cause of certain psychiatric illnesses.
If
sleep problems had resolved by the second interview, new psychiatric illness
was less likely to develop. The authors suggest that physicians could possibly
prevent new or recurrent psychiatric disorders by diagnosing and addressing
sleep complaints promptly.”
Original Abstract of the report
As
part of the National Institute of Mental Health Epidemiologic Catchment Area
study, 7954 respondents were questioned at baseline and 1 year later about
sleep complaints and psychiatric symptoms using the Diagnostic Interview
Schedule.
Of
this community sample, 10.2% and 3.2% noted insomnia and hypersomnia,
respectively, at the first interview. Forty percent of those with insomnia and
46.5% of those with hypersomnia had a psychiatric disorder compared with 16.4%
of those with no sleep complaints.
The
risk of developing new major depression was much higher in those who had
insomnia at both interviews compared with those without insomnia (odds ratio,
39.8; 95% confidence interval, 19.8 to 80.0).
The
risk of developing new major depression was much less for those who had
insomnia that had resolved by the second visit (odds ratio, 1.6; 95% confidence
interval, 0.5 to 5.3). Further research is needed to determine if early
recognition and treatment of sleep disturbances can prevent future psychiatric
disorders.
Follow is the subtitles of my article.
1.1. Disturbed sleep associated with stress, anxiety and
depression
1.2. Epidemiologic study of sleep disturbances & psychiatric
disorders
1.3. The implications of sleep disturbance epidemiology
1.4. Are sleep disturbances risk factors for anxiety,depressive?
1.5. Effects of sleep deprivation on gastric mucosal blood flow
and gastric mucosal lesions in rats
1.6. Sleep disturbances associated with minor psychiatric
disorders
1.7.Stress Hormones and Insomnia
1.8.Dopamine Imbalances Cause Sleep Disorders
1.9.Dopamine is released with the individual anxious temperament
2. The treatment of sleep disorder
2.1. Synthetic drugs on sleep disorders
2.2. Effects of Chinese drugs on sleep disorders
2.2.1. Regulatory effect of Chinese drugs on central nervous
system
2.2.2. Effects of Chinese drugs on stress-related sleep
disorders
2.2.3. Effects of Chinese drugs on sleep Deprivation
2.2.3.1. Protective effects of eleutherosides on RN_8 acupoint
application against sleep deprivation
2.2.3.2. The effect of nose drops Chinese drugs on sleep
deprivation
2.2.3.3.Effects of ginsenosides on behaviors of rats in sleep
deprivation
2.2.4. Chinese drugs on maintaining the dopamine levels
2.2.4.2. Influence of Yinxingpingchuan Formula on loss of DA
neurons and apoptosis in mice with PD
2.2.5. Chinese drugs on sedative and hypnotic
2.2.5.1. The effect of Semen Ziziphi Spinosae on Sleep
Improvement of Mice
2.2.5.2. Empirical studies of sedative and hypnotic effects of
supplemented jujube seed granules
2.2.5.3. The Sedative and hypnotic effects of Jujuboside
2.2.6. Effect of Chinese sleep drugs integrating with synthetic
sleep drugs
2.2.6.1. A controlled study of Tianmeng capsule combined with
alprazolam in somnipathy
2.2.7. Effect of Chinese sleep drug on improving the learning
ability
2.2.7.1. The effect of XinMeng Particles on learning process in
rats
8.7…Chinese
Medicine can boost immune system
This
is a reedited-excerpt of my Dec. 21 2011 article Chinese
Medicine and immune system.
With the continuous advancement of scientific research means, the understandings for our body are advancing continuously. New findings have made clear that the immune function is not only associated with the infectious diseases but also associated with non-infectious diseases closely. Such as, cancer, an uncontrolled cellular proliferation diseases associated with the immunity. Therefore, seeking the approaches to enhance our immunity have been becoming the research focus and have gotten great many fruits.
Modern researches showed that Chinese drugs contain variety of immunoreactive substances, such as polysaccharides, saponins, alkaloids, volatile substances and organic acids, etc. They are a kind of immune enhancer. Their immunoregulatory role is mainly through activation of reticuloendothelial system, so that significantly increase the IL-content, and the level of antibodies and complement, activate the macrophages and T, B lymphocytes, and enhance cellular immunity and humoral immunity, thereby enhancing the body immune system and the capacity of anti-diseases.
More amazingly, Chinese drugs can intellectually take the bidirectional role for those under different immune status. That is, for those in the lower immune function play a catalytic role, for those in the over immune function play a disincentive role, and for those in healthy condition stop any action consciously.
Follow is the subtitles of the article.
2. The effects of Chinese drugs on the development of immune organs
2.2. The effect of Chinese drugs on immune system and weight
gain of Rabbits
2.3.Effect of Taraxacum Polysaccharides on Immune Organs in Mice
2.4. The effects of Chinese drugs compound on immune organs of chickens
2.5. Effect of Chinese drugs on immunodeficiency of insomnia mice
3. The effects of Chinese drugs on the specific immune
3.1. The effects of Chinese drugs on cell-mediated immunity
3.1.1. Effects of Chinese drugs’ immunomodulator on cellular immune function in mice
3.1.2.The effects of Chinese drugs compound on celular immune function of chickens
3.2. The effect of Chinese drugs on the humoral immunity
3.2.1.The effects of Chinese drugs on the level of Newcastle disease antibody
3.2.3.The effects of Chinese drugs on Acquired immune deficiency syndrome (AIDS)
4.The effects of Chinese drugs on non-specific immune
4.1. Leukocyte and monocyte-macrophage system
4.1.1.Astragalus injection treats Leukopenia
4.1.2.The effects of anti-virus preparation of Chinese drugs on immune cells
4.1.3. The effects of compound Chinese drugs on promoting T lymphocyte proliferation
4.2. The effects of Chinese drugs on cytokines
4.2.1.The effects of Chinese drugs on cytokines in arthritis rats
4.3.The effects of Chinese drugs on natural killer cells (NKC)
4.3.3. The effects of Rhubarb on Acute Toxicity and Modulation of Innate Immune in Mice
5. The immunosuppressing effects of Chinese drugs on immune rejection of organ transplant
5.1. Effect of astragalus on CD4+CD25+ T cells and FOXP3/IL-10 in allografted mice
5.2. The Effect of Chinese drugs on Acute Rejection in Renal Transplant Rats
5.3. Effects of Chinese drugs on survival time of allogeneic transplant of pig skin
8.8…Chinese Medicine can Reduce Stress
This
is a reedited-excerpt of my July 29, 2012 article Chinese Medicine can Reduce Stress
The
study of crossing the disciplines of psychology, medicine, neuroscience, and
genetics reveals that stress causes deterioration in everything from
gums to heart and can make human more susceptible to everything from the common
cold to cancer. And those
optimistic people have lower incidence of heart disease, better prognosis
after heart surgery, and longer life.
Now,
many researches have made clear that our health is closely associated with
psychological factors or so called stress, and it is the main inducement
for various
diseases. Such as obesity, cancer, diabetes,heart attack, stress ulcer, mind
disorder, Irritable
Bowel Syndrome, retard
the wound healing, and so on.
Chinese
drugs can reduce the negative effects of stress
Chinese
drug can alleviate the stress symptoms by releasing endorphins, decreasing the
stress hormone cortisol, eliminating the oxygen free radicals, lowering the
blood pressure, reducing the heart rate, relaxing the muscle tissue, improving
the digestion and sleeping, and bringing more fresh oxygen to body tissues by
improving the circulation of blood and lymphatic fluids. This increased blood
flow will eliminate the waste products from inside the body and enhance the
nutrition supply to take an Antiaging effect.
The
effect of single Chinese drug on stress
Here,
take Ginseng, a well-known herb as example:
For
the rats in chronic restraint stress, Ginsenoside can reduce the
pathological changes in ultra-structure of adrenal cortex, improve the
reduction of activities, the decline in memory and exercise capacity, etc.
Ginseng
can reduce the reduction of ATP, glycogen, creatine phosphate content and the
increase of lactic acid content in the muscle tissue of rats in stress. Reduce
the rise of mouse rectum temperature caused by the stimulation of noise and
light.
Ginseng
can significantly reduce the mortality of mice under the condition of low
temperatures (-9 ℃)
or high temperature (46 ℃).
Extend the swimming duration time and inhibit the reduction of muscle glycogen
in swimming rats.
Chinese
Medicine can reduce the negative effects of psychological stress
Aim:
To study the effects of Banxia Houpu Soup and Guizhi Gancao Longgu Muli Soup on
the behaviors and HPA axis of chronic psychological stress rats.
Methods:
SD rats were divided into 5 groups: normal group, model groups Ⅰ and Ⅱ, Banxia Houpu Soup group and Guizhi
Gancao Longgu Muli Soup group. The behavior, the hypothalamus CRH, plasma ACTH
and serum CORT (radio-immunity method) of all the rats were observed.
Results:
On the 11th day, the crossing times of model group Ⅰ and the crossing times and
struggle time of model group Ⅱ changed obviously compared with
those of normal group. On the 19th day, the crossing times and still time of
model group Ⅰ and Ⅱ had remarkable differences,
while the contents of CRH, ACTH of model group Ⅰ and the contents of CRH, ACTH
and CORT of model group Ⅱ increased
obviously compared with those of normal group. Compared with those of model
group Ⅰ and Ⅱ, the crossing times on the 11th and
19th days and the struggle times on the 11th day of Banxia Houpu Soup group
increased obviously, while the contents of CRH and ACTH decreased; the crossing
times on the 19th day increased, but the still time on the 19th day shortened
and thecontents of ACTH and CRH decreased in Guizhi Longgu Muli Soup.
Conclusion:
Banxia Houpu Soup and Guizhi Longgu Muli Soup can affect the behavior and the
endocrinal system of the chronic psychological stress rats in a certain level
by through the action on the different sectors of the
hypothalamus-pituitary-adrenal gland axis.
Note:
Banxia Houpu Soup and Guizhi Longgu Muli Soup are both the experience compound
prescription of Chinese drugs.
8.9…Chinese Medicine and Heart Disease
This
is a reedited-excerpt of my Dec. 21 2011 article Chinese Medicine and Heart Disease.
The
researchers in MRC Clinical Sciences Center at Imperial College London
published the First Image of bleeding inside the heart muscle following a heart
attack. The article also indicates that, some people experience bleeding inside
the heart muscle, once blood pumps into it again, the patients will have a much
poorer chance of recovery.
Kirsty, a girl of Britain. Her heart grew back after a third
was removed in an emergency operation when she was 4 months old in 9
years ago. The case shows the wonderful capability of our heart on self-healing
and given us the confidence to overcome the terrible heart disease.
Most
of cardiovascular disease is chronic diseases induced by more pathogenesis and
multi-factor. In the process of occurrence and the development are often
involving the changes of pathological and gene expression in multiple organs or
parts of the body.
Chinese
medicine (CM) is used in compound formula, which has a special advantage and
efficacy to restore the health entirely in multi-level, multi-link and
multi-target. Therefore, CM possesses big potential to apply in such diseases.
Contents
1.1. Controlling the signaling pathway of cell
1.2. Regulation of electrocardiogram indexes
1.3. Regulation effect on the ET, NO ans NOS
1.3.1. Regulation of ET, NO in ischemic heart disease
1.3.2. Regulation of ET, NO in atherosclerosis
1.3.3. Regulation of ET, NO In hypertension
1.3.4. Regulation of NO, NOS in myocardial ischemia
1.4. Chinese medicine is superior to verapamil
2. Enhancing myocardial contractility
3. The effect of bi-directioal regualtion
3.1. Bi-directional regulation of the heart rate
3.2. Bi-directional regulation of blood pressure
4. Protect vascular smooth muscle tension
5. Protect myocardial cells mitochondria
6. Coronary Heart angina pectoris
9. Improve the micro vascular circulation
10. Comparison of Chinese medicine and nitroglycerin
11. Narrow after operation of coronary artery dilatation
12. Protective effect on endothelial cells
8.10…Chinese Medicine can promote Wound Healing
This
is a reedited-excerpt of my July 29, 2012 article Chinese Medicine on Wound Healing.
In Western medicine, the
suture removal after laparotomy conventionally needs to wait for healing 1 week
or more. However, it is only needs 1 or 2 days if treated by Chinese drugs.
The incision fat
liquefaction is a thorny problem clinically in Western medicine, even causing
death. However, the one on hip incision of hipbone fracture was being healed to
crust in hours by sprinkling hammered rough powder from crude Chinese herbs’
slices without sterilization.
Many successful cases
have been demonstrated that Chinese drugs have magic curative effect on chronic
refractory wounds or ulcers.
The unique potence comes
from potentiating synergistic effects of multiple bioactive constituents of
compound Chinese drugs.
The facts have subverted
the conventional process of wounds healing. Chinese drugs provided a new
effective and cheaper approach for wounds treatment especially for the chronic
refractory one. Obviously, it has promising market potential.
Following is a case that happened 10
years ago.
1998, my younger brother hipbone
fractured in a car accident. After one week of hip operation there was still 50
mm unhealed on 300 mm incision suture and happened fat liquefaction due to
doctor forgot putting a surgical drainage tube. Besides the replacement of
medical gauze and adjustment of the intravenous antibiotics conventionally, the
doctors did not give more help.
I worried about the wound infection or
necrosis, so bought some crude Chinese herbs’ slices and hammered them into
coarse powder, then sprinkling on the incision watering area directly without
sterilization. After 3 hours when I opened the covered-gauze found that the
unhealed incision has crusted entirely. The appearance showed that the crust
formed much earlier than 3 hours. The Chinese herbs’ effect surprised me very
much. Because that the incision fat liquefaction is difficult to be healed, it
needs to use Infra-red radiation or insulin, etc. Some time, it may lead to
serious consequences, such as, the symptoms of systemic poisoning.
I have been worrying for that the
wound watering outlet was being blocked too quickly. However, until now, more
than 10 years has past without any sequel.
June,2003,I
had my younger brother taken the photo on the area of incision suture as above.
From above experience, I have aroused
an idea that sprinkle the Chinese drugs powder on the wound immediately after
operation or injured to promote the wound crusted as faster as possible, so
that avoid the infections. For those needs further treatment will be helpful
from not being infected before getting suitable operation.
Contents
2. Effects of Chinese drugs on wounds healing
2.1. Restoration of wound blood circulation
2.2. The number and function of immune cells
2.4. Basic fibroblast growth factor (bFGF)
2.5. Collagen synthesis and metabolism
2.8. Granulation tissue cells’ proliferation and fibroblasts’
function
2.9. Wound contraction materials
2.10. Health beneficial wound pus’ secretion
2.11. Original shape and color’s restoration
2.13. Promote the recovery of bone fractures
2.13.1. Reconstruction of blood circulation system
2.13.2. Promotion of calcium deposition and enhance the callus
quality
2.13.3. Promotion of growth hormone secretory
3.13.4. Increase of the level of bone morphogenetic protein
2.13.5. Promotion of the TGF-β secretion of osteoblast
2.13.6. The generation of IGF-1
Follow is my article
that computer automatically dated as June 1, 2009.
The
therapeutic effect of Chinese medicine on wound and fracture healing
Frank June 1, 2009
Firstly let us see the
surprising news from Britain in 31st December 2008: The heart that grew back: 'Miracle'
of girl whose heart healed itself after a third was removed in emergency
operation. The fact showed us that our body possess big potential in self heal.
Wound healing is a
complex biological processes, particularly chronic refractory wound treatment
is difficult in clinic. Currently, the studies on this issue are from the
general to cell, molecular and genetic level. There were various types of
growth factors have started to applications, such as epidermal growth factor
(EGF), basic fibroblast growth factor (bFGF), etc.
However, the clinical
therapeutic results for those growth factors are not satisfied. It was mainly
because of there are a large number of protease exists including
metalloproteinases in the chronic refractory wound, which break down the
endogenous growth factor secreted by wound cells and exogenous growth factor.
Thus lead wound healing slowed down or even stopped. In addition, the content
of interleukin-8 (IL-8) and interleukin-10 (IL-10) is higher in the form of
autocrine, which will inhibit the tissue’s repairing, the role of collagen
production of fibroblasts is weakened, and the cell apoptosis increased.
However, for thousands
of years, Chinese medicine has showed a unique effect on wound healing by
eliminating sphacelus and promoting tissue regeneration. Here I’ll discuss its
mechanism in promoting wound healing.
Research
progress of Chinese medicine in treatment of Chronic refractory wound
The mechanism of Chinese
medicine on promoting wound healing by dressing is eliminating sphacelus and
promoting tissue regeneration by generatiing pus to protect the wound healing.
Chinese medicine is good
immune enhancers. Dressing on wound, can generate a lot of useful pus that is a
sort of multi-nutritional fluid from the local micro vessel, which is rich in
immune active cells and immune active factor. They can effectively regulate the
function of cells of wound tissue. Thus take the effect of anti-infection and
the promotion of wound healing. In the medium-term of wound healing, if such
pus is more enough the wound healing would be faster.
Animal skin ulcer
experiments, Vaseline gauze and Chinese medicine two group. After 12 days,
Chinese medicine group, the fibroblasts is not only increase in the number also
more active and syncytium is enlarged. After 15 days, the fibroblast rough
endoplasmic reticulum is upgrowth, the content of free ribosomes is
significantly increased and found plenty of slender collagen fibers in
mesenchymal.
Treatment
of stubborn skin ulcer of lower limb by Chinese medicine dressing
Total 38 cases of
refractory skin ulcer of lower extremity, Chinese medicine is dressing on wound
to be changed daily. After one month, 14 cases were cured fully, 15 cases
improved markedly, 9 cases were effective and all patients were fully cured
within 3 months.
Promoting
the wound healing
New Zealand white
rabbits, total 30, were made wounds on back. Test group, external topical smear
with Chinese medicine solution. Control group, has no medicine.
Test group, wound
narrowed and healing faster (P<0.01), healing time is short (P<0.01).
Under Optical Microscope: found plenty of capillaries, there is lesser
inflammatory cells, the granulation formed early, and generated plenty of
fibroblast. The epithelial tissue grow toward centre is rapid. Under Electron
Microscope, The fibroblast show more exuberant ultrastructural changes in
protein synthesis.
The control group, there
are plenty of inflammatory cells. There are fewer fibroblast and capillaries.
Epithelial tissue grows relatively slow.
Wounds bacteriological
examination, bacteria is significantly less than that in control group
(P<0.01). The results showed that Chinese medicine can reduce the wound
inflammation, edema, and promote wound healing.
The
effect of Chinese Medicine on bacteriostasis, relieve ecchymosis and
eliminating sphacelus.
In 4 experimental
models: 1. Vitro bacteriostasis test in liquid-tube method. 2. Mice
subcutaneous abscess caused by mixed infection of candida albicans. 3. Local
skin ecchymosis by trauma on guinea pig. 4. Rabbits skin rot caused by
subcutaneous injection of sterile turpentine.
Results: In vitro, have
obvious inhibiting effect for six kinds of common pathogens and opportunistic
pathogen that can cause mucocutaneous infection. There is also a significant
inhibiting effect on infection. Pathological examination showed therapeutic
effect on experimental traumatic skin ecchymosis and traumatic skin ulcers by
dressing.
Mediating
wound growth factor, promoting wound healing and reducing the scar
By Chinese medicine
dressing on mice wound showed that Chinese medicine can be a significant
increase the level of bFGF in the wound healing period of inflammation and
proliferation. Thus promote wound collagen synthesis and epithelial growth. In
the wound modeling period, Chinese medicine can reduce the level of bFGF to
promote the degradation of collagen that excessively proliferated, and make
them arranged orderly, therefore reduce the formation of scar. The facts showed
that Chinese medicine is not only promoting the wound healing also promote the
scar reducing through mediating the content of bFGF.
Rat ulcer models,
Chinese medicine can increase the content of epidermal growth factor receptor
(EGFR)and the levels of vascular endothelial growth factor (VEGF) in local
wound tissue, therefore to promote the wound healing.
Promoting
wound blood circulation
Artery ischemia, venous
stasis, partial denervation and neuropathy are the direct cause of chronic
refractory wound. Therefore, promote wound blood circulation is very important
in wound healing.
Rats wound infection
model, in Chinese medicine group, the number of capillary in wound developed
much more than that of control group. The difference of temperature in wound
granulation and the one in surrounding skin is significantly higher than that
of control group. The fact indirectly proved that Chinese medicine can improve
the blood circulation of wound.
Regulating
the wound Immune Function
Rabbit wound infection
model, between 7 and 14 days after Chinese medicine dressing, generate a whole
blood neutrophil peak compared with the control group.
In guinea pigs wound
model, Chinese medicine can increase the phagocytic rate and phagocytic index
of the peritoneal macrophages and increase the percentage of lymphocyte
transformation. Thereby it enhanced the immune function of the wound.
In rat ulcer model,
Chinese medicine can increase the levels of complement C3, IgA and IgM. Increase
the content of lysozyme in pyogenic secretion and the index of thymus and
spleen. Thereby Chinese medicine can promote healing by enhancing wound
immunity.
The
impact on Fibronectin (FN)
Chinese medicine can
effectively increase the content of FN in serum and wound tissue so as to
promote wound healing.
Effect
on trace elements in wound
In rat wound model,
Chinese medicine can significantly increase the content of Zn in wound tissues
and the Cu content unchanged.
Reducing
the pH value in wound
Researches shows that
reduce the PH value can enable the release of oxygen in oxyhemoglobin and is
conducive to tissue growth. Chinese medicine can promote wound healing through
reducing the wound pH values.
Promoting
the proliferation of contraction material in wound
Actin, an important
material to promote wound contraction, is conducive to wound healing. This is
because that wound narrowed will reduce the chances of infection and only a
small number of new tissues will be able to heal it.
Animal wound model, Chinese
Medicines group, found a lot myofibroblast in granulation tissue and the
synthesis is active. Also found plenty of actin. The wound contraction is
significant better than the control group.
The
impact of amino acids on wound
Amino acids are
important material to the growth of granulation tissue. If the lack of free
amino acids, it would weaken the proliferation of connective tissue and
synthesis of collagen fibers.
Animal ulcer model, in
the 15th day of ulcer formation, Chinese Medicine group, the total amount of
amino acid hydrolysis (including ammonia) and the total amount of free amino
acids (excluding ammonia) are significantly higher than that of control group.
The content of 9 kinds of neutral amino acids and 6 kinds of essential amino
acid are all higher than the control group, in which the cystine and lysine is
the highest.
Promoting
the recovery of bone fractures
Animal fractures model,
Chinese medicine largely improved blood circulation in surrounding fracture and
systemic. Therefore, nutrition conditions were improved at the trauma
surrounding. The every wound healing stages are started early. Make the
fractures recovered ahead of schedule significantly.
Healthy adult male mice
in saline and Chinese medicine two group, 45Ca determination in liquid
scintillation, found the calcium deposition is similar around the corresponding
parts of right and left femur in normal mice. After the fracture in the middle
of the right femur, in two groups, the calcium deposition was increasing
continuously in the middle femur. However the calcium deposition is both
decreased in the upper and lower parts of the femur. But in Chinese medicine
group the decrease is more significantly. Showed that Chinese medicine can take
more additional calcium from neighboring bone tissue to the fractured area to
meet the calcium needs in new bone formation, therefore accelerate the
fractured bone healing.
In fractures rabbit’s
model, intramuscular injection of Chinese medicine, made paraffin specimens and
staining. Observed in visible light and polarized light, found that capillary
in expansion hyperaemia are appeared early in the stage of inflammatory
response. In the clean-up phase, the hemosiderin appears early in hematoma area
than the control group. The appearance of cell activity, the fibro-osseous bone
callus, the original bone callus and secondary bone callus are all earlier than
that of control group. Chinese medicine made various stages of fracture healing
all in advance than that of control group, So as to promote the healing of the
fracture.
In rabbit fracture
model, observation by electron microscope, compared with control group, in
Chinese medicine group, the callus formed in advance and denser. The number of
osteogenic cells increased. Besides the fibroblast shape changes, the cell
protein synthesis are more vigorous active. The normal process of cell
degeneration has also accelerated. Extra cellular collagen fibers increased and
into the fibroblasts cytoplasm. There are more osteoclasts appeared in
different parts of the callus to promote the bone remodeling. In addition, in
the swelling mitochondrial of fibroblasts appears number of dense calcium
particles, there are more bone calcium deposits earlier in callus.
Observation by Atomic
Absorption Spectrometry, in the earlier healing stage of tibia closed fracture,
found that Chinese medicine accelerate the growth of fractured bone and the
process of calcification through improving zinc content in serum and callus,
strengthen the zinc mobilization in adjacent bone tissue nearby fracture ends,
as well as Zn / Cu ratio
Chinese medicine can
promote the effectiveness of protein synthesis to combat post-traumatic
disorder of metabolism, changes the negative nitrogen balance. To improve local
blood supply of the fracture ends to speed up the repair of damaged soft tissue
and the absorption of edema. To promote the increase of osteoblast in number
and activity as well as the proliferation of collagen fibers and bone callus,
So that the inflammatory phase shortened, and accelerated the phases of repair
and remodeling, so as to promote the healing of the fracture.
On the basis of
regulating the overall response of the body, Chinese medicine can directly or
indirectly play the role of anti-infection by anti-bacteria. It is significantly
conducive to the treatment of susceptible infecting open fractures.
The
therapeutic role for soft tissue injury
Gardenia, a Chinese herb
medicine, alcohol solution, external smear on genital postpartum edema, the
effect is better than magnesium sulfate solution, and course of treatment
shortened, no adverse reactions.
8.11…Chinese Medicine treats on A H1N1 Flu 2009
Dec.
21 2011, in article Chinese
Medicine – A Promising Therapeutic Approach, I indicate that :
In China, it is common in CM
integrating WM clinically. That is, at the same time, a patient being treated
by two types of medicine. The advantages of WM are to take the effect quickly
toward the main symptoms and the advantages of CM are to take the effect in
eliminating the negative effects of WM by improving the patient's immunity and
overall physical condition. Greatly enhanced the therapeutic effect and made
the patient recover earlier. Also it greatly improved the life quality of
patients. The good example is the treatment of SARS.
SARS: During
the outbreak of SARS in 2003 in China, among 5326 were confirmed SARS cases,
3104 were treated by WD integrating CM. The wonderful therapeutic effect of
Chinese drug is manifested.
1. Relieve fever and shorten the
duration.
2. Improve weakness, breath shortness, dry cough and
clinical symptoms of poisoning.
3. Eliminate the toxicity and the negative effects of
Western drug, such as steroid in large doses use.
4. Help to reduce the amount of using in hormones.
5. Improve hematopoietic function and hypoxic conditions.
6. Protect the organs function and avoid organs failure.
7. Reduce the systemic
complications.
8. Promote the absorption of inflammation to avoid the bad
sequels.
As a result, no one was dead and
suffered femoral head necrosis in the group of intervening with
Chinese drugs.
We can conclude that Chinese medicine
can promote the absorption of inflammation to avoid the bad sequels, such as the femoral head necrosis of
bad sequelae of SARS. The causes for the
femoral head necrosis are still in debating
until to today, one is SARS virus, and another one is the use of
glucocorticoids in large dose.
The successful experience of mainland China on the treatment
of A H1N1 flu was that, if the treatment focuses on each symptom of the patient
to improve their physical condition by Chinese drugs besides killing the A H1N1
flu viruses. The number of developing into the critical and death was largely
reduced.
Follow is my Nov. 25,
2011 article Chinese
Medicine treats on A H1N1 Flu 2009.
In some areas the peak
of pandemic of A H1N1 Flu 2009 has passed and emerged downward trend according
to the report of WHO Dec. 11 2009. However, the seasonality of its epidemics
seems to be not obvious with an unpredictable
nature, so that no one can be sure whether it would set off another wave of
the pandemic.
It is in this emergent
situation, after careful investigation many researchers have questioned the
efficacy of neuraminidase inhibitor drug - Tamiflu in preventing complications
such as pneumonia in otherwise healthy people with seasonal flu, the drug
manufacturer had failed to provide effective data to answer the question. [1][2][3]. And the World
Health Organization has endorsed the findings. If the question comes true,
it will undoubtedly destroy the hope and confidence of public in prevention and
treatment of A H1N1 Flu 2009. It is bound to create massive panic.
The overuses of
antibiotics have been significantly activating the activity of virus mutation.
The viruses are able to develop resistant ability on new version antibiotics
once they are being put in use shortly. I think that on the current medical
technology, it seems very difficult to control the influenza virus effectively.
Fortunately, in terms of A H1N1 Flu 2009, most of those infected had mild
symptoms without heavy impairment and only fewer patients developed into
critical or death, and British scientists
studies have proven it is considerably less lethal than was feared in advance.
Therefore, we should broaden our thinking way in combating against influenza,
and turn to focus on the prevention and treatment of various complications by
developing new effective drugs. Based on the current knowledge on natural
drug’s researches, it would be feasible easily.
Now let discuss the
feasibility of Chinese medicine (CM) on treatment of A/H1N1 2009 flu
1.
The symptoms and complications of the A/H1N1 2009 flu infected
1.1. Lung cells
can be infected deeper and cause more severe symptoms than seasonal flu can.
1.2. Many severe
patients have pulmonary emboli that blocks the arteries in the lungs.
1.3. Patients was
associated with severely low levels of blood oxygen, multi-system organ failure,
needs for prolonged mechanical ventilation, and frequent use of rescue
therapies.
1.4. China, the
statistics of 1054 cases of domestic A H1N1 flu patients in July and August
2009, the results are as following.
1.4.1. The majority of
patients’ symptoms’ was mild and has improved naturally within 72 hours. The
mean fever temperature of patients is 37 degrees. Chinese medicine was
effective for the mild patients.
1.4.2. Only a few
patients are severe or critically ill and shows persistent high fever, severe
cough, phlegm, chest tightness, even sanity changes. Such as restlessness,
convulsions, some even have nausea, vomiting. There are clinical manifestations
of pneumonia. Some patients had chronic diseases before is prone to
complications. For the critically ill patients, mainly divided into two types,
one is respiratory failure-type; one is shock-type, complicated by multiple
organ failure.
1.4.3. Deaths were
mostly due to the viral pneumonia, integrated with the respiratory failure and
multiple organ dysfunctions. If the treatments focus on the specific
symptomatic besides A H1N1 virus, the patient normally would not die.
2.
The Advantages and Mechanism of CM on Treating Influenza
Chinese medicine has unique
anti-viral role: 1. Able to kill the virus directly. 2. To prevent virus
adsorption and penetration of host cells, inhibit viral replication in host
cells, blocking the virus from infected cells into uninfected cells. 3.
Inhibiting the transcription and replication of virus. 4. Can enhance the
immunity of human body. 5. Inducing the the generation of interferon. 6.
Eliminating the endotoxin. 7. Repair
damaged body tissue. Chinese medicine can play a direct and indirect anti-viral
defense role initiatively. Its unique advantages have aroused widespread
concern.
2.1. Directly killing the
virus
Some Chinese medicine
can kill the virus before them into the cells.
Researches proved that
anthraquinones, the alcohol extract of rhubarb, can directly kill the virus.
Glycyrrhizin can directly kill Zoster virus. Banlangen can kill the Herpes
virus directly.
2.2. Blocking the virus
from infected cells into uninfected cells
Active ingredient in
many Chinese medicines can inhibit the adsorption and penetration of virus on
host cells to take the anti-viral effect, such as, flavonoids, polysaccharides
and their derivatives, triterpenoids and their derivatives (such as
glycyrrhizin derivatives), alkaloids, glycosides and so on.
Astragalus can inhibit
the adsorption and penetration of the virus into the sensitive cells. Banlangen
has a strong inhibitory effect on porcine reproductive and respiratory syndrome
virus and influenza virus adsorption to host cells. In vitro, the combination
preparation of Banlangen and Astragalus has a strong inhibitory effect on the
proliferation of porcine reproductive and respiratory syndrome virus.
2.3. Inhibiting the
transcription and replication of virus
A compounds extract from
Rhubarb can inhibit the activity of 3CL protease that is major protease for
virus life cycle, and thus block the SARS virus transcription and replication.
Also, there are strong effect of anti-influenza virus and respiratory syncytial
virus. Polyphenols can inhibit the synthesis of proteins and RN of influenza
virus A.
2.4.1.
Promoting the development of immune organs
Many anti-viral Chinese
medicines are rich in nutrients that could well contribute to the enhancement
of human immunity by increasing the weight of immune organs, including central
immune organs, such as thymus, bursa of Fabricius and extrinsic peripheral
immune organs, such as, spleen, lymph node.
2.4.2. Enhancing the number
and phagocytic capacity of immune cells
Many anti-viral Chinese
medicines can increase the number of macrophages and their phagocytic capacity.
Such as, Coptis, Scutellaria, Phellodendron, Polyporus umbellatus, garlic and
so on. Some can increase the phagocytosis of white blood cells, such as,
Houttuynia, Berberine, Andrographis, Daqingye, wild chrysanthemum, paeonol,
rhubarb and honeysuckle, etc. Some can increase the monocyte phagocytosis, such
as, Acanthopanax, Astragalus, Codonopsis, Eucommia, Coptis chinensis,
Phellodendron, licorice, Ganoderma lucidum, Poria, artemisinin, Danshen and so
on.
2.4.3. Improving immune
function by regulating endocrine,
neurological and metabolic
Modern studies have
shown that there are more than 200 kinds of Chinese medicine can regulate the
human immune system, mainly through the following channels: The hypothalamus -
pituitary - adrenal cortex and other endocrine system, regulation of Nerve -
humoral, regulation of Autonomic nerves, regulation of cyclic nucleotide system,
regulation of the nucleic acid metabolism and regulation of the quantity and
quality of T lymphocytes.
Interferon can make
uninfected cells produce anti-viral protein, thus inhibiting the biosynthesis
of viral macromolecule, and makes the cells acquire anti-virus capabilities.
The interferon produced in the cells of invasion parts, can permeable to
adjacent cells, thereby limiting the virus to spread around.
Modern research confirms
that there are many Chinese medicines have a role of inducing endogenous IFN or
procuring the inducing effect. Such as, the mushrooms element extracted from
the mushroom, could induce serum IFN. The glycyrrhizin extracted from licorice
and glycyrrhetinic acid preparations can induce type Ⅱ IFN, and enhancing the function of
cellular immune. Some can induce interferon and immune globulin, which has
anti-viral effect, such as, Astragalus, Salvia, Acanthopanax, gentian, etc.
2.6. Enhancing the activity
of natural killer cells (NK)
Studies proved that
Chinese medicine prescription of Xiao Chai Hu Tang and ginseng doctrine can
markedly enhance the activity of Natural killer cell.
2.7.
Eliminating the endotoxin.
2.8.
Repair damaged body tissue.
3. The researches of the
constituents of anti-viral Chinese medicine
Polysaccharide is an
important constituent of Chinese medicine, has many physiological functions.
One of them is to activate immune cells. Such as, T lymphocytes, B lymphocytes,
macrophages, natural killer cells (NK), cytotoxic cells (CTL) and so on.
3.1.1. Enhancing the
function of T lymphocytes
The studies have shown
that Lycium Bararum Polysaccharides (LBP), Ligustrum lucidum polysaccharide,
epimedium polysaccharide, Astragalus polysaccharide and so on, can enhance the
function of T lymphocytes with the immunomodulatory effect that is similar to
Thymosin, the acting target is thymus. Mushroom polysaccharide is a typical
T-lymphocyte enhancer, which can promote the generation of specific cytotoxic T
lymphocyte (CTL) in vivo, and to enhance the killing activity of the CTL.
3.1.2. Improving the level
of antibody
Evergreen polysaccharide
can promote the phagocytic function of macrophages and enhance its ability in
processing and delivering the antigen. Therefore raise the levels of antibody.
3.1.3. Affecting the
complement system
In vivo and vitro, the
Bupleurum polysaccharide, Artemsia argyi polysaccharides, Angelica
polysaccharide, Pachymaran, Mushroom polysaccharide, Plantago polysaccharide
and Jujube polysaccharide can activate complement.
3.1.4. Affecting interleukin
(IL)
The vast majority of
polysaccharide can promote the generation of IL-1 and IL-2. Mushroom
polysaccharide can promote the release IL-3 of the spleen lymphocyte.
Phytolacca polysaccharide can promote the T lymphocytes to produce IL-2.
3.1.5. Promoting the
generation of interferon (IFN)
Versicolor
Polysaccharide (PSK) can promote the Lymphocytes to generate interferon. That
Astragalus polysaccharide, ginseng polysaccharides, Bupleurum polysaccharide,
Acanthopanax polysaccharides, Tremella polysaccharides, angelica polysaccharide
and so on, can induce interferon generation.
Volatile oil makes
Chinese medicine has a flavor, mainly containing sulfide, terpenoids and
aromatic compounds, etc.
3.2.1. Allicin, the
volatile oil of garlic, has significant effect in immune enhancement. It can
increase the content of serum lysozyme and activity of some enzyme.
3.2.2.
Volatile oil of
Patchouli leaf
In mice model
pharmacology method of serum with volatile oil of Patchouli leaf, the results
are as following:
3.2.2.1. Peripheral
white blood cells: Showed very significant activating effect, after 3.0h and
4.0h P<0.01, after 6.0h P<0.05.
3.2.2.2. Peritoneal
macrophages: Showed significant
activating effect, after 3h P<0.05, after 4.0h and 6.0h P<0.01.
3.2.2.3. Spleen
lymphocytes: Showed significant effect in proliferation, after 3.0h、4.0h
and 6.0h P<0.05.
3.2.2.4.
Antitussive
and Expectorant
In ammonia induced cough
and phenol red secretion mice model, Volatile oil of Patchouli leaf could
significantly prolong the ammonia spray time of cause 50% mice cough (EDT50)
and promote the phenol red excretion in mouse trachea.
Pharmacological
experiments demonstrates that Forsythia essential oil has a protective effect
on influenza virus infection in mice. In chick embryo it can inhibit the
proliferation of Asian influenza and parainfluenza Sendai strain.
3.4.
Organic acid
In recent years, the
study found many of the organic acids in Chinese medicine possess biological
activity.
3.4.1. Glycyrrhizic acid has been
proven to enhance the immune function of animals.
3.4.2. In mice
model, Folium Isatidis ( Isatis indigotica Fort ) acids can inhibit ear edema
induced by P-xylene, significantly reduce the peritoneal Evans blue extravasation
of mouse induced by acetic acid and significantly reduce the yeast-induced
hyperthermia.
3.5.
Saponin
3.5.1. Saponins of Bupleurum can
reduce the tissue cells damage caused by inflammation through inhibiting
the allergic reactions virus-induced.
3.5.2. Ginsenoside can inhibit
stress-induced immunosuppressive effects by the hypothalamus - pituitary -
adrenal axis, Neuropeptide Y-HPAA and NPY-sympathetic - immune regulation
pathway.
3.6.
Alkali
3.6.1. Matrine of
Sophora can reduce the liver cell degeneration and necrosis that hepatitis B
virus-induced, and promote the regeneration and repair of liver cell.
8.12…..No death of
SARS treated by Chinese Medicine
Bob Flaws, an active
interpreter and practitioner of Chinese
medicine with western background, said in An Interview, “that the
combination of Western medicinals and Chinese medicinals is, for many disease
processes, better than either of them individually. Typically, you get a better
therapeutic effect with a smaller dosage of Western meds and have to take the
Western meds for a shorter period of time. Clinicians know that most of the
side-effects of Western drugs are dose-related and that, if you can keep the
dosage minimal and the duration as short as possible, you'll get the
therapeutic result without the adverse reactions. Chinese medicinals taken with
Western medicines seem, in many cases, to achieve that therapeutic goal.”
In
China, it is common in CM integrating WM clinically. That is, at the same time,
a patient being treated by two types of medicine. The advantages of WM are to
take the effect quickly toward the main symptoms and the advantages of CM are
to take the effect in eliminating the negative effects of WM by improving the
patient's immunity and overall physical condition. Greatly enhanced the
therapeutic effect and made the patient recover earlier. Also it greatly
improved the life quality of patients. The good example is the treatment of
SARS.
SARS:
During the outbreak of SARS in 2003 in China, among 5326 were confirmed SARS
cases, 3104 were treated by WD integrating CM. The wonderful therapeutic effect
of Chinese drug is manifested.
1.
Relieve fever and shorten the duration.
2.
Improve weakness, breath shortness, dry cough and clinical symptoms of
poisoning.
3.
Eliminate the toxicity and the negative effects of Western drug, such as
steroid in large doses use.
4.
Help to reduce the amount of using in hormones.
5.
Improve hematopoietic function and hypoxic conditions.
6.
Protect the organs function and avoid organs failure.
7.
Reduce the systemic complications.
8.
Promote the absorption of inflammation to avoid the bad sequels. Such as the
femoral head necrosis of bad sequelae of SARS. That the causes are still in
debating, one is SARS virus, and another one is the use of glucocorticoids in
large dose.
As
a result, no one was dead in the group of intervening with Chinese drugs.
8.13… Chinese medicine can cure AIDS
There
are many reports that Chinese medicine can play a positive role in the
treatment of the AIDS.
August
8th 2016, article Kenya:
Chinese herbal therapy gains ground in Africa reported that Nairobi based
Professor Tian Shengxun invented herbal concoction that called as Tian Immunity
Booster (TIB) to remedy the effects of tuberculosis, HIV Aids and related
complications.
TIB
is manufactured through modern technology as proper compounds extracted from
more than 30 different pure Chinese herbs, which blocks the fusion between HIV
and CD4 cells, stopping HIV from infecting CD4 cells, so that HIV will rapture,
or die, within 72 hours, if HIV has not accessed CD4 cells. Therefore TIB
offers true cure to HIV/Aids.
Prof.
Shengxun says that TIB can survive HIV/AIDS patients for more than 12 years.
Studies conducted on TIB by Dr. Josef Schneider at Freiburg University
(Germany) and similar studies at Biological Mimetics Inc in Maryland State
(USA) reveal the drug can reverse HIV/AIDS symptoms.
The
first oral TIB therapy has been clinically used for HIV/AIDS for the past
almost 20 years mainly in Africa and Asia. It comes at a time Traditional
Chinese Medicines (TCM) have gained prominence in Africa, and are being used
side-by-side with conventional medicines.
The
drug forms part of global efforts to find the elusive anti-retroviral therapy,
and ensuring access to lifesaving medicine to end the AIDS epidemic by 2030. It
comes at a time Traditional Chinese Medicines (TCM) have gained prominence in
Africa, and are being used side-by-side with conventional medicines.
World
Health Organization (WHO) estimates that 370,000 Kenyans died last year of NCDs
and the trend will only worsen. Speaking in Nairobi, Prof. Shengxun says as
alternative HIV/AIDS therapy, patients using TIB can survive for more than 12
years. Studies conducted on TIB by Dr. Josef Schneider at Freiburg University
(Germany) and similar studies at Biological Mimetics Inc in Maryland State
(USA) reveal the drug can reverse HIV/AIDS symptoms.
Sept.
10, 2015, TCM
tonic herb 'can kill HIV', study finds - China reports that: Sex-booster herb Schisandra has shown
promise in treating HIV/AIDS, according to a 20-year-long study led by the
Kunming Institute of Botany of the Chinese Academy of Sciences.
Native
to North China, the Korean Peninsula and Russia, the plant has been widely used
in TCM for 2,000 years as a tonic that enhances the function of the liver and
kidneys and improves memory and sexual performance.
Several
derivatives of the herb's lignin, which is the compound extracted from the
leaves and stems of the woody vine plant, have strong anti-HIV properties and
low toxicity.
Current
TCM treatment for HIV/AIDS mainly focuses on immunity maintenance. Unlike that,
the Schisandraceae study showed that the compound can kill the virus itself.
Since
2004, China has treated more than 27,000 sufferers of HIV/AIDS with TCM treatment.
Studies found that with a combination of mainstream antiretroviral therapy and
TCM treatment, the patients benefited in particular by experiencing boosted
immunity.
Follow is the information about Schisandra:
Schisandra
Schisandra is a plant. The fruit is used as food and also to make medicine with following function:
1.. Used as an “adaptogen” for increasing resistance to disease and stress,
increasing energy, and increasing physical performance and endurance.
2..For preventing early aging and
increasing lifespan; normalizing blood sugar and blood pressure; and stimulating the immune system and
speeding recovery after surgery.
3..For treating liver disease
(hepatitis) and protecting the liver from
poisons. The Chinese have developed a liver-protecting drug called DBD that is
made from schisandrin, one of the chemicals in schisandra.
4..For treatment of high cholesterol, coughs, asthma,sleep problems
(insomnia), nerve pain, premenstrual syndrome (PMS),
chronic diarrhea, dysentery, night sweats, spontaneous sweating, involuntary discharge of semen, thirst, erectile dysfunction (ED), physical exhaustion, excessive urination,depression, irritability, and memory loss.
5..For improving vision,
protecting against radiation, preventing motion sickness, preventing infection, boosting energy at the
cellular level, counteracting the effects of sugar, and improving the health of
the adrenal glands.
The chemicals in schisandra improve liver function by
stimulating enzymes (proteins that speed up biochemical reactions) in the liver
and promoting liver cell growth.
Dec.
2008, article Popular Use
of Traditional Chinese Medicine in HIV Patients in the HAART era reported
that:
Seventy-six
Chinese male HIV patients were interviewed on their use of traditional Chinese
medicine (TCM). All except one had undetectable viral load, 28 had already
progressed to AIDS. Forty-five (59.2%) had used TCM - 11 infrequently and 33
commonly. No specific TCM recipe was preferentially used, while a variety of
herbal tea and other over-the-counter health products of TCM in origin were
reported.
A
minority (28.9%) have consulted a TCM practitioner in the preceding 6 months.
Most patients admitted using TCM for the treatment of minor ailments (60.0%) and
general health maintenance (57.8%), while western medicine was chosen for the
therapy of major medical illnesses.
TCM
did not seem to have significant influence on the conventional HAART in this
cohort. Many used TCM at a time interval from HAART in order not to affect the
latter's effectiveness.
Oct.
19, 2010, article Traditional
Chinese medicine trial gets results against HIV/AIDS reported that:
An
ongoing three-year traditional Chinese medical (TCM) trial has achieved
breakthroughs in combating HIV/AIDS, Guang'anmen Hospital in Beijing announced
on Saturday.
The
565 AIDS patients' condition and immune systems were reportedly remarkably
improved, with coughing and tiredness lessened since the trial began in 2008,
according to the Beijing Daily.
Animal
experiments had demonstrated their treatment could suppress multiplication of
the HIV-1 virus in cells, according to the hospital website report on a of
HIV/AIDS Prevention and Treatment on October 16 and 17.
Western
treatment like Highly Active Antiretroviral Therapy (HAART) can kill almost all
the viruses in the blood, said AIDS expert Jin Wei, but the virus could not be
totally eliminated.
TCM
strengthens the immune system.
HAART
is expensive and has strong side effects, said hospital president Zhang Jie,
leaving 10-15 percent of patients unable to rebuild their immune system after
the treatment. "The Chinese medicine is cheap, almost side effect-free and
can boost the improvement of the immune system," he said.
Not
everyone was impressed with the alleged advance of the city hospital.
"Government experts receive special funding from the nation. If they work
hard and invent a cure, they will lose their funding," said an employee of
a private TCM company who requested anonymity.
The
government sets strict rules on medical trials and private organizations were
effectively ruled out of conducting AIDS research, he said. "As the
government doesn't support us, we moved to Africa to conduct TCM experiments
and we have a close relationship with the health administration of one African
nation."
In
that experiment, "the antigen turned negative," he said. This
indicated they had found a cure, he asserted.
He
refused to reveal the name of the nation, as the alleged spectacular result has
not been proven effective by international societies.
Source:
Global Times (By Xu Tianran)
8.14…Chinese medicine can cure cancer
The researchers of Canada have proved
the effective of ancient Chinese herbal medicine on Canacer.
Windsor Regional Cancer
Centre in Ontario, Canada proved that dandelion root can kill cancer cells.
It just is the one in follow photo that easily grows in our yard lawn and makes
us headache, which has been medicinal used in treating variety of diseases for
thousand years in China.
Siyaram Pande is a Biochemist at the University of Windsor and
leading research. The first phase of the studies showed that dandelion root
extract forces an aggressive type of cancer known as myelocytic myeloid
leukaemia to commit suicide. They tested the extract from dandelion root on
several lines of leukaemia cells and found that the extract caused these cells
to commit suicide, a process known as apoptosis.
Dandelion immune boosting effects
Dandelion root can restore inhibition of nitric oxide by cadmium
in macrophages. Nitric oxide is important for immune regulation and defence of
the organism while cadmium inhibits the production of nitric oxide. A study
published in 1998 in Immunopharmacology and Immunotoxicology found that
dandelion root extract can induce and restore the secretion of tumor necrosis
factor-alfa, showing its immune boosting properties.
Dandelion anti-cancer effects
Medical science is finally beginning to accept the positive
results of dandelion root extract in healing cancer. The past few years,
clinical research has been published stating about positive effects of
dandelion for cancer.
The studies have found that dandelion root extract have a potent
anticancer activity against prostate cancer, colon cancer, breast cancer, leukemia,
liver cancer and best of all lung cancer.
Dandelion root contains a phytochemical Taraxasterol and
beta-sitosterol, natural compounds with potent chemotherapeutic and
chemoprotective effects. A summary published in Neoplasma in 2004 reported many
positive effects of these phytochemicals, especially the anti-tumor and
chemotherapeutic activity inhibiting breast and colon cancer, tumorigenesis,
prevention of metastasis, and inducing cell division.
Dandelion root extract is effective against breast and uterine
cancer. A study examined dandelion cytotoxic effects against these types of
cancer and showed that dandelion reduced the tumor size by 26% while the
production of immune-boosting molecules was increased.
All of this shows the effectiveness of dandelion root in the
treatment of cancer. It is the best to use dandelion root in a form of powder.
A little over a half teaspoon of the powder once a day at any time will be more
that enough for a successful cancer treatment. You should not expect a miracle
because this is not an overnight cure so it will take a time until the body
removes cancer.
10 Health Benefits of Dandelion Root
http://www.realfoodforlife.com/dandelion-root-health-benefits/
The
dandelion Root is a very economical herb considering that it is a weed that
most of us dig and get rid of! I have been eating it for years.
Dandelion
is a great spring tonic for our bodies; it helps the transition from winter to
the warmer season, by nourishing and balancing the blood so it will flow better
and keep us cooler in the summer season.
1…Widely
recognized as a liver tonic as it nourishes the liver.
2…Because
of its high iron and zinc content, dandelion root is often used as a treatment
for anemia.
3…Has
mild laxative properties and is often used to help maintain regularity.
4…Recognized
as a great blood builder and for the liver.
5…Aids
skin problems as well as detoxify poisons and toxic waste in the body.
6…It
is also a mild appetite stimulant; tea made from root and leaves can help
relieve digestive problems.
7…Dandelion
root functions as a mild diuretic. Because potassium is often lost when using a
diuretic, dandelion root is often a better choice for a diuretic than synthetic
formulas.
8…Lowers
cholesterol according to some studies. Early results of at least one study show
that dandelion root supplements may affect the cholesterol profile in diabetic
mice positively by lowering LDL and triglycerides while increasing HDL.
9…Its
positive effects on the liver and digestion, may help the effectiveness of
other vitamins, minerals and nutrients.
10…“Dandelion
acts as a tonic to the system. It destroys acid in the blood. As it contains
organic sodium, it is very good for the deficiency of nutritive salts, and is
recognized as a great blood builder and purifier.“ from the book Herbally Yours
Dandelion
root Nutrition:
Filled
with vitamins A, C, D and B complex, with abundant of zinc, iron, potassium,
calcium and other nutrients.
Follow is a research report
Dandelion (Taraxacum
officinale and Tmongolicum)
http://www.imjournal.com/resources/web_pdfs/0409_yarnell.pdf
Abstract
Dandelion
(Taraxacum spp) is used in many traditional and modern herbal medical systems,
as particularly has been documented in Asia, Europe, and North America. The
root is primarily considered a gastrointestinal remedy supporting digestion and
liver function, while the leaf is used as a diuretic and bitter digestive
stimulant.
Preclinical
research on dandelion has revealed numerous properties, including its actions
as an inflammation modulator, diuretic, digestive stimulant, insulin stimulant,
demulcent, prebiotic, immunomodulator, antiangiogenic, and antineoplastic,
although not all studies agree.
There
are very limited numbers of clinical trials involving dandelion, and almost all
of these involve complex herbal formulas containing dandelion as only 1 part.
These formulas have been shown to counter indigestion, mildly help metabolize
androgenic hormones, counter hepatitis B infection, reverse Helicobacter
pylori-related gastritis, and reverse intestinal metaplasia. Overall, dandelion
is very safe, although it may aggravate acute gastrointestinal inflammation.
Further research is warranted on this widely-used, intriguing herbal medicine.
Dandelion
(Taraxacum spp) is used in many traditional and modern herbal medical systems,
as has been documented particularly in Asia, Europe, and North America.
The
root is primarily considered a gastrointestinal remedy, supporting digestion
and liver function, while the leaf is used as a diuretic and bitter digestive
stimulant.
History and Folk Use
Dandelions
are among the most recognizable weeds in the world. Traditional use goes so far
back as to predate written records. The leaf of Chinese dandelion (T
mongolicum) was first mentioned in writing in the Tang Materia Medica (659 AD)
and is classically considered a valuable remedy in Chinese medicine, both
topically and internally, for treating abscesses, reducing eye inflammation,
and provoking diuresis.
Throughout
its enormous growing range, all parts of the dandelion were eaten as food.
Chemical Composition
Among
the most important compounds in dandelion are sesquiterpene lactones (believed
to have antiinflammatory and anticancer effects), phenylpropanoids (believed to
have inflammationmodulating effects), triterpenoid saponins (effects unknown
for this herb; well known for many others; eg, the adaptogenic effects found in
plants such as Panax ginseng), and polysaccharides (complex carbohydrates).
Major sesquiterpene lactones, generally occurring as glycosides (sugars),
include taraxacosides, taraxacolides, dihydrolactucin, ixerin, taraxinic acids,
and ainslioside.5 Phenylpropanoids (cinnamic acid derivatives) are plentifully
present and include cichoric acid, monocaffeoyltartaric acid, 4-caffoeylquinic
acid, chlorogenic acid, caffeic acid, and related compounds. Inulin (a class of
fibers known as fructans) is also present in large amounts in dandelion root.
Dandelion
leaf is a good source of potassium; 1 analysis found that 100 g (just over 3
oz) of leaf contained 297 mg potassium, putting it in a league with other high
potassium-source foods.7 This means that, by dry weight, up to 4% of dandelion
leaf is potassium. However, it should be pointed out that foodlevel doses (not
the smaller medicinal doses) of leaf must be ingested to obtain potassium. A 5
mL (1 tsp) dose of leaf tincture with a 1:2 (weight:volume) ratio containing 4%
potassium would provide just 100 mg of potassium, approximately one-fifteenth
the dose necessary to be clinically relevant.
Pharmacology
Dandelion
leaf and root have both been studied for their effects on digestion, mostly as
bitter digestive stimulants. Dandelion root has been investigated for
demulcent, prebiotic, hypoglycemic, and immune-modulating effects. Dandelion
leaf has also been investigated as a diuretic and inflammation modulator.
Demulcent and Prebiotic
Activity:
Dandelion
roots have a distinct demulcent action and prebiotic properties due to their
content of inulin8 ; fall-harvested roots have the highest inulin content.
Digestion, Inflammation,
and Angiogenesis:
Sesquiterpene
lactones impart a bitter taste to the plant, which is especially notable in the
leaf but also in the root (particularly when spring-harvested).9 These
compounds also likely explain the increase in bile production seen in animal
studies with dandelion,10 with the studies themselves lending support to the traditional
use of dandelion as a bitter digestive stimulant. One study showed that
sesquiterpene lactones contributed to the inflammation-modulating properties of
dandelion root.
Other
studies showed that crude extracts of both root and flower modulated inflammation,
and some evidence suggests that phenylpropanoids might be key to this
activity.12,13 Ethanol extracts of the dried aerial parts have been shown in
rodent studies to reduce inflammation and inhibit angiogenesis, though which
constituents were responsible for these effects were not investigated.
Hypoglycemic Effects:
Dandelion
root and leaf repeatedly have been shown to have hypoglycemic properties,
though the exact mechanisms of action are poorly understood.15,16 Of concern,
at least 1 report attributes this property to an insulin secretagogue effect
(ie, stimulating pancreatic beta-cell release of insulin).17 This mechanism
could lead to further insulin resistance and contribute to beta-cell burnout in
patients with diabetes. This said, however, at least 1 mouse study has failed
to confirm any hypoglycemic effects of dandelion.18 Human trials are necessary
to clarify dandelion’s effects on blood sugar and determine if the herb may be
helpful or harmful for people with diabetes.
Immunity:
Studies
on the effects of various dandelion extracts and compounds on the immune system
are contradictory, some showing inhibition and some stimulation of tumor
necrosis factor, for example.19,20 This may suggest that dandelion extract has
various effects on different lymphocyte populations or body tissues, or it may
indicate that dandelion can modulate immune reactions. The polysaccharides in
dandelion, of which there are many, are often credited with being key
intermediaries in immune interactions.21 More in-depth research is needed on
dandelion’s immune-system effects.
Miscellaneous
Preclinical Studies:
In
vitro and rodent studies consistently show that various parts of dandelion have
antineoplastic activity. The leaf was more antioxidant than the root in vitro.
Dandelion leaf has proven diuretic in rats, though at fairly high doses in 1
study and only to a modest degree in another. Another study failed to find a
diuretic action of oral or intraperitoneal dandelion extracts.27 Recently, an
animal study showed that a dandelion extract upregulated estrogen,
progesterone, and follicle-stimulating hormone receptors in mice.28 Other
effects of dandelion appear to be the resultof multiple constituents acting in
concert, although lack of research makes it difficult to draw conclusions.
Clinical Applications,
Western Studies
Bitter
and Diuretic Principles: For most clinical uses, dandelion has not been
scrutinized rigorously according to modern scientific methods. Traditionally,
the leaf is regarded as a useful bitter and moderately potent diuretic. Though
no study has yet been published to support these uses, a preliminary trial
documenting dandelion leaf ’s diuretic activity was in press at the time of
writing this article (Spelman K, et al. J Altern Complemen Med. 2008). The
German Commission E approves the use of dandelion as a diuretic and also for
use in anorexia, dyspepsia, and biliary abnormalities.
Detoxification:
Dandelion
root has a long history of use for supporting liver function and treating
various dermatologic and systemic disorders, based on the theory that the herb
improves the liver’s ability to detoxify. These ideas have received little
research attention.
In
regard to hormone detoxification, a recent study compared the effects of an
herbal formula containing dandelion (specifically, T officinalis), turmeric
(Curcuma longa), artichoke (Cynara scolymus), rosemary (Rosmarinus
officinalis), schisandra (Schisandra chinensis), and milk thistle (Silybum
marianum), a healthy diet, and placebo on hormone levels in 40 premenopausal
women.30 The study ran for 4 menstrual cycles. Compared with the other 2
treatments, the herbal formula caused significant declines in early
follicular-phase androgens with no effect on levels of any other sex steroid
hormone. The implications of this study are hard to determine, but it does
suggest that dandelion and other herbs may have some role in enhancing
detoxification of androgens.
Gastrointestinal
Complaints:
The
use of dandelion leaf for indigestion or other atonic gastrointestinal
complaints is also largely unverified by modern studies. However, a case series
of 24 patients with nonspecific, chronic colitis treated with a formula
consisting of dandelion (specifically, T officinal), St John’s wort (Hypericum
perforatum), lemon balm (Melissa officinalis), calendula (Calendula
officinalis), and fennel (Foeniculum vulgare) demonstrated remarkable
symptomatic improvement in terms of stool normalization and pain reduction.31
Warts: The traditional use of fresh
dandelion stem latex to treat warts has not been evaluated.
Clinical Applications:
Chinese
Studies Several Chinese-language studies have reported on the effects of
various formulas containing T mongolicum. Unfortunately, full text translations
of these studies are not available, and the information provided here is based
solely on English-language abstracts. Therefore interpretation of these studies
must be undertaken cautiously.
Antibiotic Actions:
An
herbal formula known as fu zheng qu xie * was just as effective as the antibiotic
gentamycin in 75 cases of gastric disease caused by
Helicobacter pylori (formerly known as Campylobacter pyloridis or CP).32 This
study found that in the Chinese herbal medicine group, clinical symptoms
obviously improved—with the curative effective rate for CP at 80% (24 of 30
patients), the death rate for CP at 30% (9/30), and the effective rate for
pathohistological changes at 50% (15/30). Differences of curative effective
rate between the two groups were statistically insignificant (P>.05).
Hepatitis
B: A formula called jie du yang gan gao * (JY) was significantly more effective
than another botanical formulation (the main ingredients of which were charred
hawthorn [Fructus Crataegi], charred germinated barley [Fructrus Hordei
Germinatus], and wheat bran) in lowering elevated liver enzymes and curing
patients with hepatitis B in a 96-person, doubleblind trial.33 Cure meant that
serum hepatitis B virus (HBV)- DNA become negative. According to the abstract,
27% of JY-group patients had normalization of serum alanine aminotransferase
levels (ALT, chemicals that liver cells release when they are damaged or sick)
and 32% became HBV-DNA negative compared to just 9% and 18% (respectively) of
the other group.
Intestinal Metaplasia:
The
herbal formula xiao wei yan powder† was quite effective at reversing intestinal
metaplasia in 120 patients (91%-92% of patients normalized), compared with 120
untreated controls (only 14%-21% normalized).
Dosage and
Sustainability
Recommended
doses of the crude dried root or leaf Taraxacum spp range from 4 to 10 g daily
in divided doses. Fresh root or leaf can be consumed as food at levels of 50 g
or greater per day according to traditional knowledge. Based on our experience,
typical doses of root or leaf tinctures in the United States are 3 to 5 mL 3
times/day.
The
British Herbal Pharmacopoeia (BPH) recommends 0.5 to 2 g of root or 4 to 8 mL
of root tincture , both 3 times/day.35 The German Commission E Monographs
recommend doses of 3 to 4 g of root twice daily or 10 to 15 drops of tincture 3
times/day.
BPH recommends 3 to 5 g of leaf or 5 to 10 mL
of leaf tincture, both 2 times/day. Commission E recommends 4 to 10 g of leaf
or 2 to 5 mL of tincture, both 3 times/day.
Dandelion is a prolific weed that has
naturalized in temperate regions around the globe. As a result, it is not
environmentally threatened in any way. The widespread use of herbicides to kill
dandelions suggests that they should not be harvested from urban settings
without first determining if they have been sprayed.
Safety and Drug
Interactions
Dandelion
is a commonly available food with a long history of human use and as such poses
little risk of harm. Dandelion extracts are listed on the US Food and Drug
Administration’s “generally recognized as safe” (GRAS) list for foods and
supplements. Allergy to dandelion can occur but is rare. Patients sensi-tized to
other members of the Asteraceae plant family are sometimes cross-sensitized to
dandelion.
Dandelion
doses up to 6 g/kg in rabbits have shown no toxicity. Consumption of diets
containing 33% dandelion for months produced no toxic effects in rats.38 No
negative effects in humans have been reported during pregnancy or lactation, in
children, or in combination with pharmaceutical drugs. One study in rats found
that 2 g/kg body weight taken with the drug ciprofloxacin greatly impaired
absorption of this antibiotic, presumably due to the mineral content of
dandelion leaf,39 as minerals are known to chelate ciprofloxacin and block its
absorption and activity.
Because
it is a bitter, dandelion should be used with caution in patients with acute
gastrointestinal inflammation or obstruction or in those with nonatonic reflux
esophagitis. Bitters can potentially stimulate or aggravate these conditions.
Conclusion
Dandelion
is widely used in traditional and natural medicine systems around the world yet
has received surprisingly little research attention. Given that some
preclinical and clinical research has suggested this gentle, safe remedy may
have significant activity, further research is clearly essential.
Cancer-fighting
tea set for clinical trials in Ontario - Calgary - CBC News
Human
clinical trials on for cancer killing dandelion extract | University of Windsor
Sept.
8, 2016, article Study
shows how Chinese medicine kills cancer cells published in the
journal Oncotarget
reports that the researchers at the University of Adelaide have shown a complex
mix of plant compounds derived from ancient clinical practice in China – a
Traditional Chinese Medicine (TCM) – works to kill cancer cells.
The
plant compounds was kushen injection (CKI), it was approved for use in China to
treat various cancer tumours, usually as an adjunct to western
chemotherapy.
The
study was use of extracts from the roots of two medicinal herbs, Kushen and
Baituling (CKI) – by applying what’s known as a systems biology approach - a
way of analysing complex biological systems that attempts to take into account
all measurable aspects of the system rather than focussing on a single
variable.
They
use high-throughput next generation sequencing technologies to identify genes
and biological pathways targeted by CKI when applied to breast cancer cells
grown in the laboratory.
The
result shows that the patterns of gene expression triggered by CKI affect the
same pathways as western chemotherapy but by acting on different genes in the
same pathways.
These
genes regulate the cell cycle of division and death, and it seems that CKI
alters the way the cell cycle is regulated to push cancer cells down the cell
death pathway, therefore killing the cells.
The
article said that individual compounds don’t have much activity on their own,
it’s the combination of compounds which can be effective, and potentially means
few side-effects as well.
The
study explained the effective of herbal medicine based on the theory of
Traditional Chinese Medicine from genetic level.
May
12, 1999, Form
of Chinese herb found to temper immune system and kill cancer reports that:
Researchers at the School of Medicine,
Stanford University have discovered that a
perennial herb Tripterygium Wilfordii hook, a vine that grows in Southern
China, have medicinal properties, used by the Chinese for hundreds of years to
relieve rheumatoid arthritis symptoms has much more far-reaching medicinal
qualities.
The scientists found that the active component of the herb is
a drug that is able to suppress an overactive immune system, prevent
inflammation and kill cancer cells.
By using a
pure preparation of triptolide, the active compound within the plant, the
Stanford scientists have found that the drug exerts its effects by preventing
activation of a DNA-binding protein, NF-KB, after it has partnered with its DNA
target. This protein is a pivotal molecule that, once active, escalates an
immune response by switching on other immunologically important genes.
8.15...Chinese Medicine is effective in anti-aging
1.1. Directly scavenge the free radicals
1.2. Enhance the activity of antioxidant enzymes
1.2.3. Ginsenoside can significantly increase the activity of serum superoxide dismutase (SOD)
1.4.1. Antioxidant activiy and protection effect of salvianolic acids on DNA damage
2. Nitric oxide and Nitric oxide synthase
5. Regulation of the endocrine
6. The effect of Tai Chi Chuan exercise on immune function
Introduction
Everyone hopes long
live, but no one satisfied. Then, what is the cause of aging. There are many
theories about aging. The comparative recognized one is the free-radical theory of aging
that was put forward by Denham Harman. He indicates that the oxidative free
radicals are byproduct of normal cell function when cells create energy. They
cause DNA, proteins and other essential molecules do not function as they
should. Over time, these damages cause and accumulate us to experience aging.
Luckily, the enzymes superoxide dismutase (SOD) and antioxidants
can scavenge the free radicals to maintain it at normal levels to slow down the
process of aging. Then makes us healthy and stronger……
With the age increasing,
the balance has gradually been destroyed, resulting in excess of free radicals.
They accumulate the process of aging, and make us weaker and weaker……
Although no one can
avoid the final result presently, however we do can delay the process of aging.
On this purpose, besides healthy life style, there are many other ways that
could help us to fight against the development of aging. For example, in
animal’s model, studies have shown that increasing the amount of antioxidants
in diets can slow down the effects of aging effectively.
Though the free radical
theory of aging did not fully explain all the changes that occurred during the
aging, however, studies have proven that free radicals are the important part
in the aging equation.
Recent decades,
researchers have been finding great many bioactive constituents of anti-aging
that have powerful Antiaging properties in Chinese drugs. It
can prolong the life span of organism by many ways, such as anti-oxidation,
immunoregulation, neuro-regulation, endocrine secretion regulation, anti-DNA
injury, etc. It can relieve all the fatigue impairs for men and women, enhance
the ability of hearing and seeing, and restore the color of beard and hair for
elderly, etc.
Here, I will introduce
those exciting results and the mechanism in anti-aging.
In recent years, new
mechanisms of anti-oxidation were being found continuously. There is a growing
trend in the application of natural antioxidants.
Researches showed that
the efficacies of Chinese drugs are closely related with its effect of
anti-oxidation, and there were many botanical Antioxidants have been found.
Such as flavonoids, saponins, polysaccharides, organic acid and terpenes, etc.
These substances can
inhibit the generation of free radicals, directly scavenge free radical,
inhibit the injure effect of free radicals, and also can enhance the body's own
systemic defense function on anti-oxidation. From multi-aspect block the damage
effect of free radicals, and take the therapeutic and protective effect on
human body by restoring the oxidized material.
At present, The
protective effect of Chinese drugs on oxidative damage mainly include the
following:
1.1…Directly scavenge the free
radicals
Using the classical
method of pyrogallicacid autoxidation, found that in 8 different Chinese drugs
there were 7 can inhibit the autoxidation of pyrogallicacid and remove the
superoxide anion radical.
1.2… Enhance the activity of
antioxidant enzymes
Through a series of
catalytic reaction the antioxidase can change the free radicals into harmless
materials. The main antioxidase in cells is the superoxide dismutase (SOD),
glutathione peroxidase (GSH-Px) and catalase (CAT). Chinese drugs can increase
their level of the activity and number. Following is a clinical trial paper.
1.2.1... Changes
in Blood Superoxide Dismutase before and after Treatment of Chinese Drugs in
Patients with Nephrosis
Methods: Sixty-eight
cases of nephrosis were divided into treatment group and control group, the
reinforcing the kidney and promoting blood circulation was applied to treatment
group on the base of control group treatment. Then changes of serum superoxide
dismutase (SOD) and lipid perixidatio (LPO) were compared between the two
groups.
Results: The serum SOD
level in nephrosis patients was lower than that in healthy children (P<0.01),
but the serum levels of LPO were higher in nephrosis patients than in healthy
children (P<0.01).
After four-week treatment, the serum level of SOD increased obviously(P<0.01).
The serum levels of LPO decreased obviously in treatment group. There were
significant difference between the two group(P<0.01).
Conclusion: Chinese
drugs for reinforcing the kidney and promoting blood circulation can increase
the activity of SOD to antagonise the damage peroxide-induced, and therefore
can treat the weakness of kidney.
METHODS: The senile
models of mice were established by subcutaneous injection of D-galactosamine at
the nape,and administrated with homologus
drugs. After 8 weeks,the mice were killed,and
the activity of superoxide dismutase(SOD)and
glutathione peroxidase(GSH-PX)in
serum and liver tissues were detected by biochemistry method and the weight of
immune organs such as spleen and thymus were measured.
RESULTS: In APS group,the
spleen index and the activity of SOD and GSH-PX in liver tissues and serum were
increased; in APS plus TG group the spleen index,the
activities of SOD and GSH-PX in serum and liver tissues were significantly
increased; in TG group,the activity of GSH-PX in liver
tissues was significantly increased.
CONCLUSION: APS and APS
combination with TG can increase the activity of SOD and GSH-PX in serum and
liver tissues and the weight of immunity organs,so
APS and APS combination with TG have anti-senility effects.
1.2.3… In
aging mice model, studies have shown that Ginsenoside can significantly
increase the activity of serum superoxide dismutase (SOD) and Glutathione peroxidase (GSH-PX),
reduce the content of lipid peroxide (LPO) and its metabolites malondialdehyde
(MDA), reduce the damage to cells, also reduce the deposition of lipofuscin in
brain and myocardial to achieve the effect of anti-aging.
Studies suggest that
some flavonoids can take anti-lipid peroxidation effect by forming hydrogen
bonds with the cell membrane to protect that unsaturated bond of cell membrane
contact with free radicals.
Salvia is a strong
free radical scavenger, extracted water-soluble components have a strong
inhibitory effect on lipid peroxidation of microsomes of brain, liver,
kidney in experimental rat. The antioxidant effect of salvianolic acid A is
hundred times than that of vitamin E.
1.4...Reduce the damage
of DNA
The damage of DNA is the
primary procedure in the development of the aging process. Excess free radicals
can attack and damage the DNA, thus triggering a variety of diseases and start
the aging process. The reports on the studies of the anti-DNA damage by Chinese
drugs are increasing. By enhancing the capacity of antioxidant and immune
function, Chinese drugs can delay the shortening of the telomere length,
improve the repair capacity of damaged DNA, and inhibit the formation of end
products of the glycosylation, etc. to achieve the anti-aging purposes.
1.4.1… Antioxidant
activiy and protection effect of salvianolic acids on DNA damage
Abstract:
Objective: To study on the antioxidant activity of salvianolic acids and
mechanisms of it’s protecting against DNA oxidative damage.
Methods:Free
radical model was employed to investigate the scavenging activity to 1,1-diphenyl-2-picryl-hydrazyl(DPPH)
and hydroxyl free radicals. The mechanisms of the effects of salvianolic acids
on protection against DNA damage was measured by chemiluminescence on the
reaction system of phenanthroline (Phen)-CuSO4-VC-H2O2-DNA. Salvianolic acids
composition in samples was determined according to HPLC analysis.
Results: The
hemi-inhibitable concentration (IC50) of crude aqueous extract(AE),ethylacetate
extract(EE),resin extract(RE),ascorbate
(VC) and butylated hydroxytoluene (BHT) to DPPH free radicals were 141.2,15.3,14.6,15.8
and 71.5μg/ml. Three extracts could obviously inhibit and delay DNA damage
caused by hydroxyl free radicals. The IC50 value of chemiluminescence of AE,EE
and RE were 1293.6,62.0,and
49.2μg/ml. The scavenging activity and protective effects against DNA damage
were affected by the level of salvianolic acids composition and salvianolic
acid B.
Conclusion:
salvianolic acids can effectively scavenge DPPH and hydroxyl free radicals,protect
against DNA damage which belongs to preventive and chain-breaking antioxidants,and
the effects are related to the level of salvianolic acid B.
2…Nitric
oxide and Nitric oxide synthase
Under normal
physiological conditions, NO can play an important role on the relaxation of
vascular endothelial and maintenance of blood pressure balance. However, in
high concentrations, NO can react with reactive oxygen species to produce
nitroso radicals, this is a higher oxidative substance. Thus, the NO can also
act as a free radical and led to cell oxidative damage. When
ischemia-reperfusion injury, the activity of inducible Nitric oxide synthase
(iNOS) increased, this is the main NO synthase, it can cause the formation of
oxidative damage by producing a large number of NO. Studies found that many
flavonoids can inhibit the activity of iNOS in ischemia-reperfusion injury,
such as, the quercetin and curcumin.
The Aging is closely
related to the state of humans’ immune defense functions. A sound immune
function can prevent the infectious and non-infectious diseases. Also
appropriate regulation of immune system in the level of cellular and molecular
can delay the process of aging.
Researches show that Chinese drugs have
following immunoregulatory effects:
3.1. Make the antibodies
form early and extend the existent time.
3.2. Regulate the Gene
transcription of T cells Fas to reduce the excessive apoptosis of T cells in
old rats.
3.3. Regulate the
function of physiological and biochemical from aging state going back to
normal. Such as: Nervous systems, endocrine system, body metabolism and free
radical scavenging fuction.
3.4. Enhance the
phagocytic capacity of reticuloendothelial system, promote the formation of
antibody, and increase the content of immunoglobulin in blood and Increase the
cAMP and cGMP.
3.5. To stimulate
conversion function of lymphocytes for elderly and increase the synthesis of
DNA, RNA and protein in bone marrow cell.
3.6. Increase the
absolute value of peripheral blood lymphocytes and iicrease the OD value of
producing cells of spleen antibody.
3.7. Promote the
production of specific antibodies to enhance the Humoral immune function.
Central nervous system is highly vulnerable
to the effects of free radicals and cause degenerative diseases. The studies found that a lot of Chinese drugs
have protective effect for nerve cells.
4.1. Improve the function of nerve cells in
the hippocampus of young and aged rats, promote the c-fos gene expression of
hippocampal cells, confront the neurotoxicity mediated by glutamate and protect
primary cultured rat hippocampus cells.
4.2. Mediate the balance of
the catecholamines (γ - aminobutyric acid, norepinephrine) and 5 - HT of
central nervous media, not only can cure insomnia also can cure neurasthenia
and significant change the autonomic disorders.
4.3. Inhibit the memory
impairment induced by anisodine, increase the monoamine neurotransmitters in
brain and improve the learning and memory abilities in normal mice. For aged rats it can significantly improve
the transient memory, memory span, the reaction time of complex movements and
the ability of action and operation.
4.4. Reduce the
injury of cerebral hypoxia-ischemia, cerebral ischemia - reperfusion, anti-free
radical damage. Regulate the ET, NO levels in brain and enzyme metabolic
abnormalities. Inhibit calcium channel of brain cell, etc. In senile diseases
of the nervous system, such as, Alzheimer’s disease and Parkinson’s disease
show pharmacological effects in gene level.
Methods: The oxidative
stress injury cell model was induced by H2O2. The change of cell morphology was
observed. The activity of hippocampal neurons was detected with MTT method. The
vitalities of superoxide dismutase (SOD) and glutathion peroxidase (GSHPx) were
detected by chemical colorimetry. The expression of OGG1 mRNA was detected by
RT PCR.
Results: Compared with
model group, the morphology damage of hippocampal neurons were slighter, and
the activities of hippocampal neurons in APS group (0.46) were higher than
those of model group (0.36) (P<0.01). The
vitalities of SOD and GSHPx in APS group were higher than those in model group.
APS obviously raised the expression of OGG1 mRNA.
Conclusion: APS can
enhance the expression of OGG1 mRNA and protect the hippocampal neurons from
oxidative stress injury.
5.
Regulation of the endocrine
In the aging process,
the cells apoptosis and organ dysfunction was controlled by neural-endocrine.
Chinese drugs can improve and enhance endocrine function to anti-aging for the
elderly. Some Chinese drugs, such as: Aconite, Ginseng, Astragalus, Eucommia,
Cordyceps, Psoralen, and Cistanche, etc. can delay the human aging by
increasing the lymphocytes glucocorticoid receptor, the concentration of saliva
cortisol, promoting the adrenal function, improving the endocrine level of the
elderly. Water extract of Ganoderma lucidum can play an anti-aging role by
regulating a wide range of metabolic activities through strengthening the
endocrine system (Such as, hypothalamic – pituitary - gonadal axis), thyroid
system and adrenocortical function.
6. The effect
of Tai Chi Chuan exercise on immune function
After 25 min exercise
performance in the group those have been exercising Tai Chi Chuan for many
years, the percentage of the CD3, CD4 cell increased, the ratio of CD4/CD8
increased and the percentage of CD16 cells decreased.
In quiet state, compared
with that of non-Tai Chi Chuan group, those in Tai Chi Chuan group, the
percentage of CD3 and CD4 cells is higher; the percentage of CD8 cells is
higher but without statistical significance.
Tai Chi Chuan exercise
can enhance the regulatory capacity of the cellular immune, and improve the
body's cellular immune function.
7.
Anti-stress
Chinese drug can
alleviate the stress symptoms by releasing endorphins, decreasing the stress
hormone cortisol, eliminating the oxygen free radicals, lowering the blood
pressure, reducing the heart rate, relaxing the muscle tissue, improving the
digestion and sleeping, and bringing more fresh oxygen to body tissues by
improving the circulation of blood and lymphatic fluids. This increased blood
flow will eliminate the waste products from inside the body and enhance the
nutrition supply to take an Antiaging effect.
8.16...Chinese medicine for anti renal
damage and improve kidney function
Herb extract intravenous
injection is effective in the protection of the damage of renal tubular
epithelial of dog situ-kidney caused by hot ischemia. Intravenous injection of
2.0 g / kg and 0.5 g / kg of Chinese medicine, show the effect in adjustment of
serum-creatinine concentration, the rate of creatinine clearance and the rate
of free water clearance for the rabbit Kidney after hot ischemia. Above
evidence confirmed that Chinese medicine possess a certain ability in
protection and restore of rabbit kidney after hot ischemia.
Cryopreservation dog
kidneys in HCA preservation solution by adding and not adding Chinese medicine,
compare the changes of tissue and ultrastructure of dog kidney. The results
show that tubular epithelial cell degeneration in experimental group are less
than the control group (P<0.05) after 12,24 and 36 hours. Kidney
ultrastructure is no significant difference between the two groups in 0 hour,
slight difference after 12 hours, more pronounced differences after 24 hours,
significantly differences after 36 hours. Chinese medicines have better effect
on anti-ischemic renal injury.
Chinese medicine can
significantly reduce the acute renal failure caused by glycerol and the content
of serum urea nitrogen and creatinine in the rat liver. The first 48 hours
survival rate was significantly improved. These prove that Chinese medicine
possesses strong prevention effect on acute renal failure. There is evidence
indicate the prevention effect associated with adenosine receptor.
Protect the acute renal
failure induced by glycerol through improving the microcirculation, inhibiting
the lipid peroxidation, reducing the calcium overload in renal tissue and
protecting the enzymes activity of renal antioxidant and ATP.
Injection 8ml dissolved
in 250ml of normal saline. once daily, it is effective in treatment of moderate
renal failure.
Chinese medicine
injection shows significant effect for kidney disease of serious diabetes
complications.
Herb extracts 2g/kg
intravenous injection can increase the blood flow in rabbit kidney.
Treat rat renal failure
induced by adenine, herb extract 100mg/kg, intraperitoneal administration,
reduced the blood urea nitrogen, and creatinine. Significantly increase the
rate of glomerular filtration(GFR),renal plasma flow (RPF),renal blood flow
(RBF). Significantly increase the discharge urea, sodium and inorganic
phosphorus in urinary. Kidney function was significantly improved.
For early rats kidney
damage induced by gastric feeding grass carp bile, intraperitoneal injection,
herb extract 2.5g/kg, 5g/kg, 2 times daily, a total of 4 times, can reduce the
serum creatinine and N-acetyl-β-D-glucoside-enzyme (NAG enzyme) in urinary. And
can reduce the number of necrosis in proximal tubule epithelial cells.
Protect the kidney
1.Conservation of tissue
antioxidant capacity.
2.Reduce the injury of
the renal structure and renal function caused by blood reperfusion.
3.Effective prevent the
acute ischemic renal failure.
4.Significantly reduce
the levels of blood urea nitrogen and creatinine, and increase the output
significantly through urine.
5.Decreased blood
non-protein nitrogen, retard the development of chronic renal failure.
6. Direct inhibit growth of rat mesangial cell
and the synthesis of mesangial cell DNA and Protein.
7. Increase protein synthesis of amino
acids in the blood, reduce synthesis of urea in liver and kidney.
8. Inhibit the
decomposition of protein, in particular the muscle protein.
9.Promote the excretion
of urea and creatinine.
8.17.
..Chinese
Medicine can improve Sexual Function
This is the revised
version of my Dec. 21 2011 article Chinese
Medicine and Sexual Function.
8.17. 1. Introduction
8.17. 2.
The sexual function improvement for male
8.17. 2.1.
The effect of Chinese drugs on the secretion function of the endocrine system
8.17. 2.2.
Increase the weight of reproductive organs and enhance gonadal function
8.17. 2.3.
Restore the damaged sexual organs
8.17. 2.4.
Improve the sexual desire
8.17. 2.5.
Improve the erectile function by increasing the expression of nitric oxide
synthase
8.17. 2.7.
Restore the sexual function for aged male
8.17. 2.8.
Resist the injury of chronic psychological stress on human reproductive
function
8.17. 2.8.1.
Regulatory role of Chinese drugs on reproductive system of stress animals
8.17. 2.8.2.
Regulatory role on the dysfunction of neural reproductive endocrine under the
stress
8.17.2.9.
Effects of Chinese drugs on exercise-induced low serum testosterone
8.17.2.10.
Effects of Chinese drugs on partial androgen deficiency of elderly
8.17. 2.11.
Male infertility
8.17. 2.11.1
Sperm generation capsule treats 1645 cases of male infertility
8.17. 3.
The sexual function improvement for female
8.17. 3.1.
The improvement of female sexual arousal dysfunction
8.17. 3.1.1.
Effect of Icariin on the NO-cGMP pathway in clitoris erection
8.17. 3.2.
Effects of Chinese drugs on the Hypophysis-gonad Axis in female rats
8.17. 3.2.1.
The effects of Icariin on Pituitary-gonadal Axis in female rat
8.17. 3.4.
Restore the sexual function for aged female
8.17. 3.4.1.
The clinical observation of climacteric Syndrome treated with Yikunning
8.17. 3.4.2.
Effect of Climacteric Happiness on Perimenopausal Rat’s Hormone
8.17. 3.5.
Resist the injury of chronic psychological stress on female reproductive
function
8.17.3.5.1.
Effect of Repeated Immobilization Stress on Ovarian Function in Female Rats
8.17. 3.5.4.
Effects of Chinese drugs on hypothalamus-pituitary-ovary axis in Hanging
Stressed female mice
8.17. 3.6.
Female infertility
This topic was aroused
by the article of Viagra
May Cause Heart Attack Deaths in Younger Men with No Heart Problems. It
said that there were 522 people died in standard Viagra dosages, most of them
from cardiovascular causes.
Viagra acts by
inhibiting cGMP specific phosphodiesterase type 5, an enzyme that regulates
blood flow in the penis. At the time in improving the erectile function
powerfully, it caused many deadly inverse effects, too. Such as, priapism,
severe hypotension, myocardial infarction, ventricular arrhythmias, sudden
death, stroke and increased intraocular pressure, sneezing, headache,
flushing, dyspepsia, prolonged erections, palpitations and photophobia. Visual
changes include blurring of vision and a curious bluish tinge.
According to the point
of view of Chinese medicine that the enhancement of sexual function must be
based on the improvement of overall health condition physically and
psychologically rather than directly stimulate the artery expansion of local
sexual organ by artificial chemicals.
From the attitude to the
treatment of impotence, we can understand the different affect of the
philosophy between the Western medicine and Chinese medicine -- reductionism
and holism. The root of deadly side effect of Viagra is from the philosophical
approach, which viewing the process of sexual erection was as same as the
process of a water pump supply. It ignored the physical and psychological
factors.
The testosterone
supplement therapy (TST) and the hormone replacement therapy (HRT) both can
improve the life quality for elderly people by improving the aging-related
degeneration of reproductive system. However, they have deadly inverse effects,
too.
Based on the holistic
philosophical approach, Chinese drugs have wonderful therapeutic effect on
restoring the aging-related sexual dysfunction with lesser negative effect.
Here, I will introduce some of modern research results of Chinese drugs on the
improvement of human sexual function.
8.17.2.
The sexual function improvement for male
Chinese drugs can
enhance the sexual function from many aspects. Such as, it can improve the
secretion function of the endocrine system, increase the weight of reproductive
organs, enhance the gonadal function, restore the damaged sexual organs,
increase the sexual desire, improve the erectile function, etc.
8.17.2.1.
The effect of Chinese drugs on the
secretion function of the endocrine system
Some
Chinese drugs can improve the secretion function of the endocrine system by
improving the function of hypothalamus - pituitary – gonadal axis, adrenal axis
and thymus axis, etc. Therefore, it take the effect of improving the sexual
function indirectly.
8.17.2.2. Increase the weight of
reproductive organs and enhance gonadal function
In
hydrocortisone treated rat model, Epimedium decoction gavages can significantly
improve the sick symptoms of rats, and significant increase the weight of
prostate, uterus, adrenal, thymus, seminal vesicle, levator ani muscle and
sponge ball muscle, increase the levels of the estradiol and the plasma
testosterone. In vitro, Icariin can significantly promote the TS secrete of the
Rat’s Leydig cells.
Male
mice administered epimedium decoction can increase the content of plasma
testosterone (TS), increase weight of the testicular and the levator ani
muscle.
8.17. 2.3. Restore the damaged sexual
organs
In
impotence mice model, Epimedium extract can improve the DNA synthesis,
promote the protein synthesis, regulate the cell metabolism and increase the
body weight.
Epimedium
decoction can effectively repair the injury of the Rat’s Leydig cells and
maintain the normal spermatogenic cycle of the testicular seminiferous tubules
epithelial.
8.17. 2.4. Improve the sexual desire
Epimedium
extractum has androgen-like effect, can promote the secretion of dog semen.
The hormone activity of Epimedium extracts injection 20-40mg was equal to 7.5
mg of testosterone. Epimedium polysaccharide can affect the endocrine function
of pituitary and increase the level of sex hormones.
Epimedium
can significantly increase the sex desire through increasing the secretion of
semen, after the spermatophore was being filled, it will stimulate the
sensory nerve, and indirectly cause the sexual excitement.
Icariin can directly
stimulate the secretion of estradiol in cultured follicular granulosa cell. At
higher concentrations can promote the secretion of corticosterone in adrenal
cortex.
Wolfberry polysaccharides
gavages of 10 mg / (kg BW ? d) for semi-castrated rats can significantly shorten the latency of penile
erection and the latency of mating cross, increase the percentage of mating
rats and enhance the vitality of sperm count.
8.17.2.5.
Improve the erectile function by increasing the expression of nitric oxide
synthase
After the
treatment of Icariin the erectile function was significantly improved in the
rats of erectile dysfunction. The improvement of the erectile function has
the same trend to the increase of expression of eNOS (nitric oxide synthase).
It showed that the effect of Icariin on the erectile function was through the
restoration of eNOS expression.
Icariin can increase the
concentration of cyclic guanosine monophosphate (cGMP) in corpus cavernosum
with the dosage dependent. It prompts that the mechanism of Icariin on the
penis’ erection was related with increasing the cGMP of cavernosum smooth
muscle to enhance the relaxation of the corpus cavernosum smooth muscle.
Objective: To
investigate the long-term effect and pharmacological mechanism of Icariin on
erectile dysfunction (ED).
Methods: Establish the
ED model by castrating rats, then randomly divided into 4 groups, gavages of
different doses of icariin and placebo respectively for 3 months.
Results: In castrated
rats, the serum free testosterone decreased (P<0.01), the expression of the
nNOS, iNOS mRNA and the expression of protein of corpus cavernosum was lower
than that of non-castrated group (P<0.01), and there was no eNOS expression.
However, after the gavages of different doses icariin, the expression of nNOS,
iNOS mRNA and the expression of protein increased than the placebo group
(P<0.05). Serum free testosterone had no significant changes (P>
0.05).
Conclusion: Long-term
orally administration of the Icariin can increase the expression of nNOS, iNOS
mRNA and the expression of protein in rat’s corpus cavernosum. It demonstrated
the long-term therapeutic effect of Icariin on erectile function.
2.7. Restore the sexual function for
aged male
Chinese
drugs can inhibit the decline of serum E2 and DHT and make them tend to
increase for aged rats. Therefore, protect the decline of sexual function
for aged animal. Chinese drugs can increase the receptor number of hypothalamic
cytoplasmic E2 and nuclear DHT for aged rats to make them close to the level of
youth rats. Thereby delay the aging of hypothalamus - pituitary - gonadal
axis.
Chinese
drugs compound can resist the aging degeneration of all levels spermatogenic
cells in testicular convoluted seminiferous tubules for aged male mice, and made the cell subsets
microstructure was similar to that of youth and the lipofuscin level was not
increase.
8.17.2.8.
Resist the injury of chronic psychological stress on male sexual function
Studies
have shown that the psychological stress is the common incentive for
reproductive endocrine system diseases (RESD) [1] [2]. And the psychological stressor is
increasing. Such as, social competition, work pressure, family variation,
especially ongoing financial crisis has exacerbated this trend. Therefore, the
studies of the mechanism of psychological stress inducing the RESD and the
seeking of safe and effective intervention approaches on enhancing our ability
of resilience of stressor is more pressing and practical significance.
On this purpose, Chinese
drugs have demonstrated good performance.
8.17.2.8.1. Regulatory role of Chinese
drugs on reproductive system of stress animals
In high-dose exogenous
glucocorticoid treated rats, the levels of CaM mRNA in hypothalamus and gonadal
increased, the levels of CaM mRNA in pituitary was no significant changes.
Total flavones of Epimedium can reduce the levels of CaM mRNA in hypothalamus
and testis; but, there is no significant impact on pituitary.
8.17.2.8.2. Regulatory
role on the dysfunction of neural reproductive endocrine under the stress
Methods: By rat’s tail
clamp anger method establish the psychological stress model.
Results: In model group,
the level of the hypothalamic-pituitary NE was decreaed, the level of the DA,
5-HT and 5-HIAA were increased. The levels of serum FSH, LH, E2 and P were
declined, and the levels of the NE, DA, 5-HT, 5-HIAA and T were increased
(P<0.05, P<0.01).
In Chinese drugs
compounds group, the levels of rat’s serum P and LH were significantly higher
than that of stress group, and the levels of the hypothalamic-pituitary NE and
serum FSH, E2 were increased, the levels of the hypothalamic-pituitary DA、5-HT、5-HIAA
and the serum NE、5- HT and T were decreased. Chinese
drugs can inhibit the decline of the hypothalamic pituitary NE and the serum
FSH, P, also inhibit the increase of the levels of the 5-HT, NE and T in
hypothalamic pituitary and serum (P<0.05).
Conclusions: Chinese
drugs can regulate the dysfunction of neural reproductive endocrine under the
stress.
Methods: 36 adult SD
male rats, weighing 180-220 g, divide into 6 groups randomly. ① Saline group.② Stress group. ③ LBP low dose group (gavages of 10
mg/kg). ④ LBP
high dose group (gavages 20 mg/kg). ⑤
LBP low dose + Stress group (gavages of 10 mg/kg). ⑥ LBP high dose+Stress
group (gavages 20 mg/kg). All groups were administrated for 21 days.
The stress rat’s model
was established by placing the rats into the bound boxes. Consecutively bound 5
h daily followed by exposure to 65 dB noises 1 h for 21 days.
Chinese drugs: 63%
content of Lycium barbarum polysaccharides.
Results: Model rats: In
the early stage, for the rats in stress group were easily angered, easily
frightened, often was in high degree of alert state. With the extend of the
stress time, the food intake was significantly decreased, weight was lost, fur
color was matt dull, and conduct activities decreased. Depression-like
performance emerged.
Body weight: The weight gain significantly reduced for
stress rats with the statistical significant difference (P<0.05). Compared
with the stress group, in LBP low dose, high dose and high dose + stress
groups, the rat’s weight gain markedly increased with the statistical
significant differences (P<0.05 or P<0.01). In LBP low dose + stress
group, the rat’s weight gain increased, but no statistical significance in
differences (P>0.05).
Testis and
epididymis: In LBP high dose group, the
weight gain of rat’s testis significantly increased (P<0.05) than those of
saline group and stress group. Compared the weight gain of the rat’s epididymis
between the each groups, there was no statistical significant differences
(P>0.05).
Sperm parameters: In
stress group, the number of the rat’s sperm decreased, the rate of live sperm
decreased, the rate of sperm deformity increased, compared with the saline
group, the differences are statistical significant (P<0.01). Compared with
the stress group, in LBP high dose + stress and LBP low dose + stress groups,
the number of the rat’s sperm significantly increased, the rate of the live
sperm increased, the rate of sperm deformity decreased, there are statistical
significance in differences (P<0.01 or P<0.05).
Serum testosterone:
Compared with the saline group, in the stress group, the level of the rat’s
serum testosterone significantly decreased (P<0.05). Compared with the
stress group, in LBP low dose, LBP high dose, LBP low dose + stress, LBP high
dose + stress groups, the level of the rat’s serum testosterone significantly
increased (P<0.05 or P<0.01).
Pathological patterns of
the testicular tissue: In the saline group, LBP high does group and LBP low
dose group, the rat’s testis seminiferous tubules ranged neatly, from the
basement membrane to the cavity surface, sequentially can see the visible
spermatogonia, spermatocyte and sperm cell that ranged compactly and neatly. A
large number of matured sperm can be seen in the cavity. In stress group, the
testis tissue of rats, the amount of the seminiferous tubules, the layers of
the spermatogenic cells and the number of spermatogenic cells at all levels
apparently reduced. The spermatogenic cells ranged areosis disorders and the
amount of matured sperm cells in cavity apparently decreased. In the LBP high
dose + stress group, the pattern of the rat’s testis tissue was similar to the
normal one. In the rat’s testis tissue of the LBP low dose + stress group, the
seminiferous tubule partially degenerated, the number of spermatogenic cells
decreased with areosis disorders ranged, and the amount of matured sperm cells
in cavity decreased.
Conclusion: Lycium
barbarum polysaccharides can enhance the reproductive function of chronic
mentally stress rats. The mechanism might be through the regulation of the
hypothalamus-pituitary-gonadal axis and the target receptors.
Discussion: From the
study we can understand that the psychological stress has powerful damage
effect on reproductive function. Chinese drugs have protective effect on the
reproductive function.
8.17.2.9.
Effects of Chinese drugs on exercise-induced low serum testosterone
Objective:To
observe the regulatory effect of epimeddium, broomrape and wolfberry on low
serum testosterone and hypothalamus - pituitary - gonadal axis (HPG) function
for heavy load long-term swimming rats.
Method: By rat’s load
swimming (the load increased by degrees) establishes low blood testosterone
models and divided into swimming group and swimming + Chinese drugs groups.
Results: After 6 weeks
swimming fatigue, in swimming group, the levels of the rat’s blood testosterone
decreased significantly, the corticosterone increased significantly, the ratio
of testosterone with corticosterone dropped by 71%. The dysfunction and even
failure have emerged in the morphological changes in the cell ultra-structure
of the hypothalamic GnRH neurosecretory cells, pituitary LH, FSH promote
gonadal cells and testes leydigscells in the rat’s hypothalamus - pituitary -
gonadal axis.
In swimming + Chinese
drugs group, the levels of the rats’ blood testosterone significantly increased
than that of swimming group. And the morphological changes demonstrated the
improvement at all levels cells’ ultra-structure of hypothalamus - pituitary -
gonadal axis.
Conclusions: Regulatory
hypofunction of hypothalamus - pituitary - gonadal axis is the important reason
for exercise induced rats’ low blood testosterone. Chinese drugs can
significantly improve the exercise induced low blood testosterone by regulating
the function of hypothalamus - pituitary - gonadal axis and maintaining the
integrity of the cell ultrastructure in gonadal axis.
8.17.2.10. Effects of Chinese drugs on
partial androgen deficiency of elderly
The
testosterone supplement therapy (TST) can significantly improve the symptoms of
partial androgen deficiency in the aged male (PADAM). But there is safety
issue. Such as, induce the
erythrocytosis, impair the liver function. Moreover, also there are potentially
dangerous of prostate and cardiovascular diseases. In addition, a
study showed that injection of testosterone propionate in rabbit muscle can
increase the level of serum testosterone, however, once the drug is withdrawal, the testosterone
levels will be decreased in lower than the normal levels, which emerged the
phenomenon of negative feedback. Those facts showed that the TST has
shortcomings.
8.17.2.10.1. The
protective effects of extracts of Icariin and Dodder seed on the reproductive
function of the rats with partial androgen deficiency
Abstract】
Objective To evaluate the protective effects on reproduction of
Icariin(ICA) and semen cuscutae(SSC) on partial androgen deficiency(PAD) rats.
Methods The male rat model for impaired reproduction system and partial
androgen deficiency were made by cyclophosphamide to determine the content of
serum testosterone,luteinizing hormone(LH) and follicle
stimulating hormone(FSH) after ig.ICA and SCC.The change of histology of
the testis and the penis were observed by microscope with the method of H.E
staining and TUNEL method respectively.
Results ①The contents of serum testosterone in
ICA group were statistically higher than that in control group and model
group,and were statistically lower than that
in testosterone group (P<0.05), However,contents
of serum testosterone in SSC group were higher than that in model group,and
lower than that in testosterone group.But there had no statistically difference
between SSC group and control group.②There
had no statistically difference among every group as to the contents of
LH and FSH.③The cell
apoptosis rate in rat penis in testosterone group and ICA group were
statistically lower than that in model group (P<0.05).But
there had no statisticaldifference between SSC group and model group.
Conclusions: ICA and SSC both have the
protective effects on reproduction on partial androgen deficiency rats,but
ICA is much more beneficial to PAD in the aging male(PADAM).
Objective: To evaluate
the protective effects of Icariin (ICA) and Dodder seeds (DS) on the
reproductive function of partial androgen deficiency (PAD) to explore the
alternative approaches for TST in Chinese drugs.
Methods: 60 SD
15-month-old male rats were divided into 5 groups: blank group, model group, Icariin
group, Dodder group, testosterone group, 12 in each group. The partial androgen
deficiency (PAD) model was established by drug castration with the reproductive
toxicity of cyclophosphamide.
Besides the blank group,
the other 4 groups were given intraperitoneal injection of cyclophosphamide (20
mg /kg-1 / d-1) for 5d. Then, the model group was no longer given any
medication. Icariin group was gavages 40% single Icariin-glucoside for 200 mg /
kg-1 / d-1; Dodder group was gavages dodder extract of (8:1) 200 mg / kg-1 /
d-1, and the testosterone group was subcutaneous injection of testosterone
propionate 5 mg/d-1. All was administrated once daily for 7 days.
Results: Compared with
the blank group, rats in model group, the weight was lost, the activity
reduced, the hair was curly, matte and dull yellow, the testosterone levels
declined (P<0.05), bone synthesis reduced but absorption increased and the
weight of testes and seminal vesicle reduced. Biopsy showed that the diameter
of the testicular seminiferous tubule narrowed, the spacing widened, the
seminiferous epithelial thinned, the connective tissue was hyperplasia, the
apoptosis of the spermatogenic cells and mesenchymal cells increased, the
apoptosis of smooth muscle cells of corpus cavernosum increased and the
degenerative changes emerged.
Weight of body: The
weight of rats in Icariin group, Dodder group and testosterone group were
higher than the model group’s but lower than the blank group’s, and the Icariin
group’s and Dodder group’s was lower than the testosterone group’s (P<0.05).
The weight of testis,
epididymis, seminal vesicle: Compared with the model group, the weight of rat’s
testis in all group was increased (P<0.05). But the weight of rats’
epididymis was no obvious increase.
The weight of rats’ seminal vesicle in Icariin group were higher than
the model group’s but lower than the testosterone group’s (P<0.05). The
weight of rats’ seminal vesicle in Dodder group were lower than the blank
group’s and the testosterone group’s, no significant difference with the model
group’s (P<0.05).
Serum reproductive
hormone: For the levels of rats’ serum testosterone: Icariin group’s was significantly
higher than the blank group’s and model group’s, but lower than the
testosterone group’s (P<0.05), Dodder group’s was significantly higher than
the model group’s but lower than the testosterone group’s (P<0.05), has no
significant differences with the blank group’s. The levels of the serum LH, FSH
were no significant difference in each group.
The apoptosis: Apoptotic cells in each group
have emerged. The results were as following. Icariin group’s was (34.26% ±
3.45%) and the testosterone group’s was (22.65% ± 5.17%), the two groups’
apoptosis rate were lower than the model group’s (48.28% ± 6.74%), there was a
statistical significant difference (P<0.05). Dodder group’s (41.98% ± 8.12%)
were no statistical significant difference with the model group and the blank
control group (39.68% ± 6.02%).
Conclusions: Icariin and
Dodder both have the protective effects on reproductive function of partial
androgen deficiency rats,but Icariin is
much more beneficial to the PAD in the aged male rats.
Discussion: The
Epimedium and Cuscuta are the main drugs that were used for treating male
climacteric syndrome in Chinese medicine clinically.
In this experiment,
Dodder Seed extract can significantly increase the concentration of the serum
testosterone, and increase the weight of rat body and genital testicular.
Icariin can make the testosterone concentration higher than the model group,
even higher than the blank group, can inhibit the reduction of seminal vesicle
weight and the increase of the apoptosis of smooth muscle cell of corpus
cavernosum induced by cyclophosphamide.
Epimedium and Cuscuta
can increase the diameter of testicular seminiferous tubule, increased the
intensive of the seminiferous tubule, increase the spermatogenic cells and
interstitial cell. It showed that Epimedium and Cuscuta can slow down the
degenerative changes of testicular tissues with androgen-like or androgenic
promotion-like effect. They can fight against PAD, but the effect was more
moderate, weaker than that of testosterone propionate.
Icariin and Dodder Seed
are pure traditional Chinese drugs. The price is lower, the effect is moderate
with low toxicity, suitable for long-term use, has the potential to become an
ideal treatment drugs for PADAM.
Opinion derived from
above paper: If the Icariin and Dodder was used in integrating or used in
integrating with testosterone will be gotten much better results from their
potentiating synergistic effects. The dosage and the side effect of the
testosterone would be decreased largely.
8.17.2.11. Male
infertility
The United States does have
infertility rate-17 percent, and this rate continues going up. However, China
has the lowest infertility rate, less that 3 percent. The lower infertility
rate was contributed from the natural Chinese drugs rather than the difference
of the ethnic origin. Because that the reproductive function is an important
part of the sexual function, which can not be separated from. Chinese drugs
will naturally improve the reproductive function at the time in improving the
sexual function.
Here, I will introduce
the wonderful therapeutic effect of Chinese drugs on male infertility by
clinical cases.
8.17.2.11.1 Sperm
generation capsule treats 1645 cases of male infertility
Cases selection: 1645
cases of male infertility, among them, 21 - 30- year-old was 584 cases (35.50%), 31 -
40-year-old was 1036 cases (62.98%), over 40-year-old was 25 cases (1.52%). The
infertile course was 1.5 - 14 years. They are no congenital hypoplasia, no bilateral
cryptorchidism, no bilateral epididymal tuberculosis, normal in vas deferens
and normal in sexual function. The gynecological examinations showed that their
spouse did not suffer any diseases that affect the reproductive.
Drugs: Sperm generation
capsule was made of compound Chinese drugs. Each capsule was equivalent to the
crude drug of 4.54g. 5 capsule x 3 times daily with an empty stomach, 3 months
for a course of treatment.
Standard of efficacy:
(1) Recovery: The spouse had been pregnant; (2) Marked effective: Semen
examination resumed to normal; (3) Effective: Semen examination resumed to
normal partially; (4) Ineffective: After 3 months treatment, the semen
examination was no obvious change.
Results: Recovery was
971 cases (59.03%); marked effect was 385 cases (23.40%); effective was 231
cases (14.04%); ineffective was 58 cases (3.53%). The total effective rate was
96.47%. In the treatment of courses, the shortest one was 24 days, the longest
one was 180 days and the average was 56 days.
The reasons of
ineffective were that those patients’ sperm density was less than 1 million /
ml or suffering the sperm immobility syndrome.
Conclusion: The sperm
generation capsule can enhance the gonadal function by increasing the number of
sperm, enhancing the motility of sperm, reducing the occurrence of abnormal
sperm and improving the liquefaction time.
8.17.3. The sexual function
improvement for female
The
main Chinese drugs on the enhancement of sexual function for female are similar
to those for male. This is because that the treatment of sexual function in
Chinese medicine is focusing on the improvement of the overall health condition
rather than that of the Viagra focused on the sexual organ only.
8.17.3.1. The improvement of female
sexual arousal dysfunction
Chinese drugs can enhance the female sexual
arousal ability and sexual pleasure by improving the relaxation of corpus
cavernosum clitoridis and vaginal smooth muscle. The increased relaxation will
help to increase the blood flow velocity and volume in clitoris and vagina to
enhance their sexual sensitivity.
8.17.3.1.1. Effect of Icariin on the NO-cGMP
pathway in clitoris erection
Methods:
In vivo, vitro tested the nitric oxide synthase (NOS) and the expression of
phosphodiesterase type 5 (PDE5) in the corpus cavernosum clitoridis. By SNP
stimulating observed the effect of Icariin on the levels of cGMP. By primary
cultured smooth muscle cells of rabbit’s clitoral corpus cavernosum observed
the activity of NO and NOS. By the model of ovariectomized rat’s sexual
dysfunction and the Laser Doppler Technology observed the hemodynamic changes
on vaginal wall. After placebo-control oral administration in 5mg/kg/day for 4
weeks observed the long-term effects of Icariin.
Results:
There were NOS and PDE5 expression in the tissues of corpus cavernosum
clitoridis. Icariin markedly increased the concentration of cGMP and the
activity of NO and NOS in smooth muscle of corpus cavernosum clitoridis with
the dose-dependent.
In sexual dysfunction model group, blood flow
velocity and the area under the curve of vaginal wall were significantly
decreased than the normal control group, and the smooth muscle of vaginal wall
was significantly decreased. After 4 weeks of Icariin oral administration, the
blood flow velocity and the area under the curve of vaginal wall was
significantly increased than the normal control group, and smooth muscle of
vaginal wall was increased.
Conclusion:
Icariin can enhance the female sexual function by regulating the NO-cGMP
pathway.
Discussion:Icariin
can regulate the expression of the NOS and PDE5 and the NO-cGMP signaling
pathway in corpus cavernosum clitoridis and vaginal smooth muscle. Through
increasing the content of NO and cGMP enhance the relaxation of corpus
cavernosum clitoridis and vaginal smooth muscle. The increased relaxation will
help to increase the blood flow velocity and volume in clitoris and vagina.
Thereby enhance the female sexual arousal ability.
Until
after 4 weeks of Icariin gavages, the velocity and the volume of the blood flow
of vaginal wall were significantly increased, and the smooth muscle was increased.
The results indicated that Chinese drugs need some times to take the better
effect because that enhanced sexual function was the natural result with the
overall health condition was being improved gradually. So that even if the
cessation of medication, the enhanced sexual function will exist
continuously.
8.17.3.1.2.
Effects of Icariin on NO production
and NOS activity of rabbit clitoral corporal smooth muscle cells
Objective:
investigate the effects of the Icariin on production of Nitric Oxide (NO) and
activity of Nitric Oxide Synthase (NOS) of smooth muscle cells in rabbit’s
corpus cavernosum clitoridis.
Methods:
By enzyme digestion method in vitro culture the smooth muscle cells of rabbit’s
corpus cavernosum clitoridis.
Results:
Cultured tissue showed typical morphological characteristics of the smooth
muscle cells. The Icariin can increase the activity of NOS and the
generation of NO (P<0.01) in smooth muscle cells of rabbit clitoral corpus
cavernosum with the concentration dependent.
Conclusion:
Icariin can increase the generation of NO of smooth muscle cells of corpus
cavernosum clitoridis by enhancing the NOS activity。Those
increased NO will enhance the relaxation of the smooth muscle under the sexual
stimulating to enhance the swollen erectile function of the clitoris.
8.17.3.2.
Effects of Chinese drugs on Pituitary-gonadal Axis in female rats
8.17.3.2.1.
The effects of Icariin on Pituitary-gonadal Axis in female rats
Methods:
4-month-old female rats model, studied the effect of Icariin on the
reproductive hormones: FSH, LH and E_2 in the serum of female rats, observed
the effect of Icariin on the development of ovarian and uterine organs . By
primary cultured pituitary cells and semi-quantitative RT-PCR studied the
effect of Icariin on the expression of FSH mRNA and LH mRNA of the Rat’s
pituitary cells.
Results:
Certain doses of Icariin can increase the secretion of the reproductive
hormones: FSH, LH and E_2 of female rat’s serum. And promote the development of
Rat’s follicle. However, for the development of uterine was no obvious impact.
Icariin can promote the secretion of FSH and LH of anterior pituitary cells and
increase the expression of FSH mRNA and LH mRNA of pituitary cells with dose
selection.
Conclusion:
Icariin can increase the secretion of the reproductive hormones: FSH, LH and
E_2 of female rat’s serum, and increase the expression of FSH mRNA and LH mRNA
of pituitary cells. Icariin can promote the development of rat’s follicle, no
obvious impact on the development of uterine.
Abstract:
Review the research results of the therapeutic mechanism of compound Chinese
drugs (CCD) on the Hypothalamus-pituitary- ovarian Axis in recent years.
Compound Chinese drugs can regulate the disordered function of autonomic nerve,
reproductive endocrine system and immune system, thereby to take the
bidirectional regulatory effect for female’s neuro-endocrine -immune system.
Animal
models selection: Early age animals, elderly age animals, ovariectomized
animals and sterilized animals by gavages of androgen, etc.
Results: The effects of CCD on sex hormones
① CCD can bidirectional
regulate the level of sex hormones, increase the level of the sex hormone
receptor, increase the levels of the endometrial PR, ER in ovariectomized rats
and promote the growth of the uterine.
② CCD can significantly
increase the levels of the serum E2, P, and the index of uterus and
ovarian for the young female rats.
③ CCD can increase the serum
E2, P, decrease the serum FSH, LH for the ovariectomized rats.
④ CCD can increase the serum
E2、FSH、LH and
decrease the GnRH in hypothalamus and plasma for the 18-month-old rats.
The
effect of CCD on the histomorphology of gonadal axis
① The adenohypophysis’
structure is clear, the sinusoid increased, the gland cells is dense, the
cytoplasm is full, the nuclei is round and large, and the nucleoli is clear.
② In polycystic ovary mice
model, increase in uterine weight, interstitial cells of polycystic ovary is
hypertrophy and the ovarian weight increased.
③ In androgen sterilized rat
induced by androgen, the ovarian weight increased, the corpus luteum increased,
the ovarian granulosa layer increased. There are eggs in dominant follicle, the
interstitial gland significantly increased.
④ The adrenal cortical zona
reticularis thinned, the lipid droplets increased.
The
effect of CCD on the neuroendocrine network
① CCD can partially improve
the endocrine disorders of the menopause rats by reducing the level of the NE,
DA of hypothalamus and NE, E2 of plasma.
② CCD can regulate the
activity of NO, NOS and the content of nNOS, mRNA in hypothalamus, in some
extent can inhibit the hormone NOS / cGMP system by affecting the nNOS
transcription.
③ CCD
can cure the idiopathic precocious puberty.
④ CCD
can regulate the synthesis and release of growth hormone and the expression of
hypothalamic protein and periventricular nucleus SS gene by regulating the
hypothalamus somatostatin, gene expression and protein expression.
⑤ CCD
can increase the level of declined hypothalamic NE of ovariectomized female
rats, reduce the abnormal increase of 5-HT and 5-HIAA, so that make the ratio
of 5-HT / NE close to normal. These indicate that Chinese drugs can improve the
disorder of the monoamine central neurotransmitters of the menopausal rats. At
the same time can increase the activity of IL-2, therefore can regulate the
immune function of cells and humoral.
8.17.3.4.
Restore the sexual function for aged female
The
histochemical examination within the genital showed that Chinese drugs can
improve the ovarian function, delay the aging process of uterine and ovarian. Such as, make the uterine
hypertrophy or normal, uterine epithelial AKP positive, and produce the corpus
luteum and follicle in ovarian.
8.17.3.4.1.
The clinical observation of
climacteric syndrome treated with Yikunning
Objective:
Observation of clinical efficacy of Yikunning (A compound Chinese drugs) on
perimenopausal syndrome.
Methods:
44 patients with perimenopausal syndrome were randomly divided into Yikunning
group and Livial group. Two groups continuously administrated for 3 months.
Then the menopausal symptoms were estimated by kupper-man score method. The
levels of the serum hormone were determined by RIA method before and after
treatment.
Results:
The effect of the Yikunning on improving the perimenopausal symptoms was better
than the Livial, there was a statistical significance. The effect of Yikunning
on improving the hormone levels was similar to the Livial, there was no
significant statistical difference.
Conclusions:
The effect of Yikunning on improving the perimenopausal symptoms is better than
the Livial and on regulating the endocrine is similar to the Livial. However,
Yikunning has the advantages of therapeutic effect lasting longer and side
effects lesser.
Discussion:
Livial
is a synthetic steroid hormones used for hormone replacement therapy (HRT). It mimics the activity of the female
sex hormones oestrogen, progesterone and androgen testosterone for aged female.
It has positive therapeutic effect clinically.
As
same as other synthetic drugs, Livial
has terrible side effects, too. Such
as, increased risk of breast cancer; increased risk of stroke and of blood
clots forming in the veins; some breakthrough bleeding or spotting in the first
few months of taking this medicine; missing a dose may increase the chance of
bleeding or spotting; stabbing pains or swelling in one leg; pain on breathing
or coughing; coughing up blood; breathlessness; sudden chest pain; sudden numbness
affecting one side or part of the body; fainting; worsening of epilepsy;
migraine or severe headaches; visual disturbances; severe abdominal complaints;
increased blood pressure; itching of the whole body; yellowing of the skin or
eyes (jaundice); severe depression.
However,
Yikunning is a pure natural compound Chinese drugs, it take the effect by
restoring the function in secreting sex hormones for aged female organs.
Therefore, its side effect is lesser and the therapeutic effect is longer.
8.17.3.4.2.
Effect of Climacteric Happiness on
Perimenopausal Rat’s Hormone
Climacteric
Happiness (CH) is a compound Chinese drugs made from the experience formula for
treating perimenopausal syndromes. After years of clinical applications and
observations, the therapeutic effect was proved. This study is from the
endocrine level to investigate the mechanisms of the therapeutic effect.
Methods:
50 female 12~15-month-old SD rats were randomly divided into 5 groups: CH high
dose group, CH medium dose group and CH low dose group, blank group and
Nylestriol group. 10 adult non-pregnant 4~5-month-old female rats set as normal
group.
Rats
in 3 CH groups were 3mL CH gavages, which containing crude drugs respectively:7.4g、3.7g
and 1.85g, rats in blank group were 3mL saline gavages and rats in normal group
were 4mL saline gavages, all group administrated once daily for 30 days.
Nilestriol group was 0.036mg Nylestriol gavages, once every 2 weeks for 30
days.
Results:
In all CH groups, the level of rat’s serum E2 was significantly higher than the
blank group (P<0.05). Compared with normal group, the level of rat’s serum
E2 of high dose CH group has no significant difference (P>0.05). The
determination results were as following table.
Table: Determination Results of Rat’s Serum
E2, FSH and LH for Each group
Groups |
E2
(pg/mL) |
FSH
(mIU/mL) |
LH
(mIU/mL) |
CH
High dose |
14.00±2.42**△ |
6.89±1.43* |
10.80±1.36** |
CH
Midium dose |
9.29±4.44**△△ |
7.52±2.56 |
10.90±1.60* |
CH
Low dose |
7.88±3.41* △△ |
8.27±2.25 |
11.20±2.70 |
Normal
Group |
16.80±5.27**
△ |
6.47±1.19* |
10.50±1.88* |
Blank Group |
4.57±2.72 △△ |
8.32±1.60 |
12.80±1.39 |
Nylestriol
Group |
17.40±5.55** |
6.24±1.35* |
10.30±2.15* |
Note:
Compared with the blank group: *P<0.05, **P<0.01; Compared with the
Nylestriol group: △P>0.05,
△△P>0.01
Conclusions:
Climacteric Happiness can increase the serum E2 level and decrease the serum
FSH, LH levels of perimenopausal rats
8.17.3.5. Resist the injury of chronic
psychological stress on female reproductive function
Psychological
stress can activate the hypothalamus - pituitary - adrenal axis, and impact the function of female
reproductive endocrine from the levels of hypothalamus, pituitary and ovarian.
Chinese drugs can take the anti-chronic psychological stress effect by
improving the female reproductive endocrine function.
8.17.3.5.1.
Effect of repeated immobilization
stress on ovarian function in female rats
Method:
Sexual matured female rats were given immobilization stress once daily for 15
d. Observe the sexual periodic change by vaginal smearing. At the same time to
observe the changes of the level of the plasma estradiol and progesterone.
Results:
Repeated stress can cause the female rat’s ovarian dysfunction. The sexual
cycle extended or no physical laws or sustained in diestrum without asexual
cycle alternating. The secretion function of ovarian estradiol was
hypofunction; the secretion function of progesterone was obvious disorder. The
plasma estradiol levels were significantly reduced in various stages of sexual
cycle and / or menstrual cycles was disorders or disappears. The progesterone level
was significantly increased and the physiological secretion pattern was
disorder. The plasma progesterone levels of some rats changed toward that of
climacteric rats.
Conclusion:
Stress can induce the ovarian dysfunction and degradation.
8.17.3.5.2. Effects of flavonoids from Cuscuta
chinensis on ovarian endocrine in female rats exposed to psychologic stress
Objective:
Observation of the regulatory role of Cuscuta flavonoids on the decline of
ovarian endocrine function caused by psychological stress.
Methods:
Established rat’s ovarian endocrine dysfunction model by composite stress of
sound - Light – electricity stimulating.
Results:
For stress rats, the Cuscuta flavonoids can significantly increase the levels
of serum E2, P and the weights of pituitary, ovarian and uterine. But there was
no significant impact on the level of adrenal ascorbic acid.
Conclusion:
The Cuscuta flavonoids can significantly improve the ovarian endocrine function
of psychological stress rats.
8.17.3.5.3. Effects of Flavonoids from Semen
Cusseta on Changes of β-EP in Hypothalamuses and FSH and LH in Anterior
Pituitaries in Female Rats Exposed to Psychological Stress
Objective: Study the regulatory mechanism
of Cuscuta flavonoids on the ovarian endocrine function of stress rats.
Methods:
Established rat’s ovarian endocrine dysfunction model by composite stress of
sound - Light – electricity stimulating.
Results:
The hypothalamic β-EP levels of psychological stress rats were significantly
increased. Cuscuta flavonoids can markedly reduce the level of hypothalamic
β-EP, increase the number of pituitary basophilic cells and the level of
pituitary LH. But there was no significant impact on the level of pituitary
FSH.
Conclusion:
Cuscuta flavonoids can significantly improve the ovarian endocrine function by
reducing the level of hypothalamic β-EP and increasing the level of pituitary
LH for psychological stress rats.
Original
name was Effect of Liuwei Dihuang
Decoction on Hypothalamus-pituitary-ovary Axis in Hanging Stress-loaded Female
Mice
Objective:
Observation of the changes of hypothalamus - pituitary - ovarian (HP0)-axis
function in hanging stress female mice and the effect of Liu Wei Di Huang Tang
(LW), a compound Chinese drug.
Methods:
By hanging stress method establish HPO axis dysfunction model in female rats,
in the first 1 – 3 d hanging 30min, then increase 30min by every 3d. No total
hanging days were mentioned.
Results:
The weight of stress mice reduced, the estrous cycle and the estrus interval
prolonged. The level of hypothalamus CnRH and pituitary LH declined, the
concentration of serum estradiol increased. Oral LW has no significant effect
on estrous cycle of stress mice, but can reduce the weight lost. Oral LW
can significantly improve the levels of the hypothalamic GnRH and pituitary LH
and significantly reduce the concentration of serum estradiol.
Conclusion:
Hanging stress can induce the dysfunction of rat’s MPO axis. LW has regulatory
effect on dysfunction of rat’s MPO axis.
8.17.3.6. Female infertility
May
11, 2009, The
Herald-Mail
reported that Area
moms say acupuncture helped them to conceive in Hagerstown city, Maryland State,
USA.
“Kelly
Morton, 37, of Hagerstown says she and husband Jason wanted to give their
daughter Meredith, 6, a sibling.”
“But
after nearly three years of trying to get pregnant and suffering through
several miscarriages, Morton says she turned to two intrauterine insemination
(IUI) procedures as well as an in vitro fertilization (IVF) procedure.”
“All three were unsuccessful, leaving
Morton physically and emotionally spent, and she and her husband still without
another child.”
“’It was devastating,’ she says.”
However,
finally she succeeds happily with the help of acupuncture and Chinese
herbs.
Kelly Morton holds daughter Sadie, 8 weeks, in
front the wall of children who have been conceived using Chinese medicine.
Sadie was conceived with the help of acupuncture and Chinese herbs.
Many
others have the same experiences.
Above
cases are sufficient to demonstrate the magic therapeutic effect of Chinese
medicine on female reproduction.
8.18…Chinese
Medicine can improve Metabolism
8.18.1...
Cell metabolism
Chinese medicine could
significantly delay the natural aging process of the human lung diploid cells,
extend the life of 1/3 around. Adding 5g/L Chinese medicine into the nutrient
solution, can significantly increase the number of viable cells, the cells
generate strong. The fact showed that Chinese medicine could enhance the
ability of cell metabolism.
8.18.2....Nnucleic
acid metabolism
Chinese medicine can
promote RNA synthesis on cultured liver cells in vitro, and can significantly
promote DNA synthesis of hematopoietic cells of bone marrow, and speed up the
splitting process of nucleated cells.
8.18..3.
Cyclic nucleotide
Chinese herbal medicine
decoction can significantly improve the content of the cyclic nucleotide (cAMP
and cGMP) in plasma and tissue, but the percentage of cAMP increased
significantly compared with the control group. Aged rats cAMP, cGMP was
significantly higher than that of young rats, but the cAMP / cGMP ratio
decreased. Chinese medicine can rectify the changes to make it close with the
young rats. The ability of regulating the plasma cyclic nucleotide is the
important role on anti-aging of Chinese medicine.
8.18..4.
Metabolism of the sugar
Increase or decrease the
blood sugar with automatic bi-directional regulation.
8.18.5.
Metabolism of protein and nucleic acid
Promote the synthesis of
DNA and protein in mouse liver, kidney and testicular. Promote the synthesis of
serum protein and liver DNA. Protection
of synthesis for myocardial cells DNA in the hypoxia and lack of sugar
situation.
8.18.6.
Nucleic acid and protein metabolism
Accelerate the uptake of
P for liver cells. Increase the synthesis of the brain protein in rats that
suffered cerebral ischemia by carotid artery legations. Stimulate the
regeneration of the liver tissue in liver resected mice.
8.18.7.
Sugar metabolism
Increase the inorganic
phosphorus and blood sugar in rabbit’s serum and increase the muscle and
hepatic glycogen. Reduce the lactate in liver and serum, but increase the
lactate in muscle. Prevent of the reduction of muscle ATP, glycogen, and
phosphate, but prevent the increase of the lactic acid and pyruvate.
8.19...Chinese medicine can promote recovery
after operation
The operation of cancer,
such as, Lung cancer requires thoracotomy, it will badly harm to the body.
Patients are often very weak physically and prone to sweating profusely, a
slight movement may cause to sweat, and chills after sweating, dry mouth, dry
cough with short of breath, irritability or fantod. Since bowel movements are
too slow, which cause distending or windy of abdomen, poor appetite, poor
urine, constipation and so on.
For the elimination of
those uncomfortable symptoms, at first is to promote bowel movements, once the
movements are promoted, all of the uncomfortable symptoms above will be
improved quickly. The mental state will gain a new look. Positive psychology
will greatly speed up the process of recovery.
Although some Western
medicine can achieve the effect of promoting bowel movements, or do not improve
the bowel movements, but can ease constipation. However, both effect are not
good than that of Chinese medicine. Chinese medicine is not only can improve
the bowel movements, but also can strengthen physical fitness, especially
strengthening the immune system significantly, thereby to speed up the process
of recovery.
Because doctors may
suspect Chinese medicine, so I chose a substitute that is Aloe Vera. As a plant
medicine, Aloe is used for thousand years in China, and Aloe Vera is popular in
North America. Now the capsule of the powder of Aloe Vera can buy in any diet
supplements store and there are producers in Toronto city. Although the
appearance of Aloe of China is different with Aloe Vera of North America, but
the main ingredients & medicinal function are similar.
Using method: 2 capsule
of Aloe Vera powder melt with alcohol, the amount of alcohol is to make the
mixture can just smear 9 square inch on bellybutton and the surrounding area.
After smearing cover the s,eared area by a piece of plastic to keep wet for 8
hour or more, if smeared area dried in this period, wet again with alcohol.
After 6 – 10 hours, patients will have one or two times stools that may be like
diarrhea but the feeling is much comfortable than that of diarrhea. Then clean
the smeared area. Thus one time of smearing each day for one week, then patient
will be much better.
The therapeutic
mechanism is that, as usual, the most of acupuncture point is connected with
one specific organ or area of body. But bellybutton is connected with the
organs and tissues of whole body. It is called as holographic acupuncture
points. Medicinal ingredients will be trans-dermal absorbed into the
acupunctural meridian and blood vessel to reach whole body, without via the
degradation of the liver, take the effect quickly with high efficacy.
Besides promoting bowel movements quickly,
Aloe Vera has therapeutic effects as following.
1. Stimulates immune response against
cancer to prolong survival time of cancer patients
2. Protect the bone marrow from damage by
toxic chemicals and drugs
3. Improve blood sugar regulation in
non-insulin dependent diabetics
4. Curtails HIV infection
5. Relieves irritable bowel syndrome
6. Reduces pain and swelling in arthritis
sufferers
7. Promote the wounds healing
8.Increase the number of spleen cells,
polymorphonuclear leukocytes, lymphocytes, monocytes and platelets and so on
9. Anti-fungal, viral
10.. Inhibit the tyrosine kinase
11. Inhibition of tumor cell
metabolism-induced apoptosis
12. Anti mutagenic
Besides Aloe Vera, better take Ginseng
Capsules 2 gram/3 times /day.
The dilemma in health care triggered the rise of Chinese medicine
I have been persisting 10 years in writing this article.
The writing of this article started in 2008 in Mandarin after I learnt the incredible Medicare Woes in the United States from documentary Sicko that directed and filmed by Mr. Michael Moore. Since Dec. 21, 2011, I translated it in English and then I have been in endless updating with difficult struggling in English wording.
Mr. Michael Moore revealed shocking reality in the Medicare and healthcare of the United States by comparison with other countries.
The United States is admired in affluent life under adorable democratic governance, its healthcare system should be in most adorable too, but, the reality that over commercialized in profit pursuit was in incredible departure from adorable.
In the United States, almost fifty million people are uninsured while the insured remainders are often victims of insurance company fraud and red tape; which caused the infant mortality and life expectancy equal to that of poor countries.
As contrast, Cuba, a poor country that has been taking as enemy and embargoing by the United States for more than 60 years, has indeed established the most humane medical system that any people from any country can get treatment in free.
In the documentary Sicko, for seeking medical help, by a small boat, Mr. Michael Moore helped three U.S. 9/11 rescue workers easily into Cuba, the poor country Cuba is freely opening its door to the people from enemy country.
The 9/11 rescue workers have been suffering sickness that caused from engaging in rescue work in 9/11 dust-flying disaster site, in order to save the lives of others, undermined the health of themselves. In own home country, in the great United States, they did not get effective medical help as national heroes should be enjoyed.
In Havana hospital of the poor country Cuba, the rescue workers got satisfied diagnosis and treatment in free without being asked for money or insurance card, the only requirement was to register by personal name and birthday in the purpose of an essential identification as patients in regardless the nationalities.
The fact was clear - the poor Cuban people have established universal healthcare system in opening to the people world widely.
The humane practice of poor country Cuba made a great irony for the rich country United States that has been self priding in acting as global mentors in the democracy and human rights.
In the documentary Sico, Mr. Michael Moore indicates that, in the U.S., Healthcare costs run nearly $ 7,000 per person; but in Cuba, they spend only $ 251. And yet the Cubans are able to have a lower infant mortality rate and a longer average life span than that of in the United States.
Then, where was the $ 7.000 per person spent for, the documentary provided secret.
A kind of medicine that needed by a patient of 9/11 rescue workers was only $5 cents in Cuba, but was $120 dollar in the United States.
Mr. Michael Moore commented the health care of Cuba with that: Their only sin when it comes to healthcare seems to be that they don't do it for a profit.
The malformed profitable healthcare leads to a deformed economy. Feb. 26, 2018, the article Warren Buffett reveals more details about healthcare venture with JPMorgan and Amazon said the U.S. spends 18 percent of its GDP on healthcare, which was the highest in the world, and that number continues to grow.
Nowadays, although the social materials wealth was increased largely, but the social polarization was increased also. There many people are struggling in the bottom of the modern society, hard working every day but less ability to afford expensive medication, well-equipped Hospitals are everywhere, but, they have no money to step in, even no ability to enjoy the fruits of modern civilization they have been hardly creating.
For unaffordable medication, the irrational commercialization was one of the reasons; the life-saving medication became the tools for looting money.
In the United States, besides that medicine sells $120 with 2400 times greedy looting in compared with $5 cents in Cuba, the hospitals was also in madly money cheating.
Nov. 19, 2014, there was a report that Canadian mom faces nearly $1-million medical bill after unexpected birth in U.S.. It said that a Saskatchewan mother is facing more than $900,000 in medical bills after giving birth unexpectedly in the United States and being told the costs won't be covered by insurance.
No matter from what point of view, for a normal childbirth, to be charged so much, it was simply a manner of robbery of the reckless robber.
On the https://www.reddit.com/, after the post The Cost of Our Baby's Birth (C-Section) in the US, there were many comments in complains about irrational charges at American hospitals.
Although the people do not have to worry about medical expenses in some rich welfare countries with available in universal health care, however, manmade poor in services, and long waits for treatment has become a new life threat. In developed country Britain and Canada, both have reports that patients died due to unable to get treatment timely.
Dec.14, 2009, British news paper Daily Mail published article Britain, the sick man of Europe: Heart and cancer survival rates among worst in developed world to have reported that the poor work ethic of British medical staff caused health care service among worst in developed world; even there were up to 1200 needless deaths patients abused staff bullied to meet targets, but hospital says no one's to blame; patients were left unwashed in their own filth for up to a month as nurses ignored their requests to use the toilet or change their sheets. Even heinous, four members of one family, including a new-born baby girl died within 18 months after of blunders at the hospital…
The shocking facts revealed that healthcare in the rich countries United States and Britain was even worse than that of poor country Cuba.
A better healthcare is important for human survival, in underdeveloped poor countries, the poor healthcare is normal in forgivable; but in developed rich countries, the poor healthcare is abnormal in unforgivable.
The reality shows that the plight in human health care was not due to the short in medical resources, but, the absurdity in social governance, which encourages some reckless people to boldly play their inhuman nature to endanger the life of innocents.
In this regard, the populist kidnap-worsened democratic governance was main cause, in which, it was not government in governing populists, but, the populists in kidnapping government and boldly doing whatever they like without worry for being punished.
All in all, the first in the firsts, the improvement of health care is depending on the rational social governance. The purpose is simple, but the practice will be difficult due to it is inevitably to be complicated by the involvement of great many thorny factors.
Besides the wrongful social governance, the mainstream western medicine itself also faces difficult position of being unable to get rid of; such as, it is incapable in dealing with the degenerative diseases that have no pathogenic origin. Recently, after huge expenditures on drug R&D failed, several pharmaceutical manufacturing giants announced the withdrawal of the drug development on Alzheimer’s. A few years ago, there were pharmaceutical giants withdrew from new version antibiotic R$D due to the rapid mutations of the virus to have largely shortened the marketing time of new developed antibiotics.
The reality is urging us to serious consider the way out for the dilemma in human health care. The best way is to explore therapeutic approaches that are easy in home use, cheaper in private affordable, so that people can be self-help in health keeping and diseases treating; by which helps people get rid of fully relying on unaffordable mainstream medicine and thereby get rid of the harm of wrongful social governance and greed of people’s inborn nature that free play in over commercialized world.
For such a concern, that folk ancestral medicine may provide help.
Among variety of the folk ancestral medicines, the Traditional Chinese Medicine (TCM) was the best one with the profound theories of thousands years accumulation in written records, which provide effective methods in diseases diagnose and treatment with broad availabilities in natural medicine - 11,146 medicinal plants, 1581 medicinal animals and 80 medicinal minerals with nearly 100 thousands of experience-based formulas.
In Cuba, due to short of money, they promote preventive medicine and hardly seek cheaper effective medications, in which, Chinese medicine has been playing a key role.
Follow were some of the reports.
Natural and Traditional Medicine in Cuba: Lessons For U.S. Medical Education.
Cuba's Green Revolution - Natural Medicine Advances.
In addition, there was report that in the US, the not-for-profit and public hospitals have developed unsustainable.
28 August 2018, article Research Announcement: Moody's - US NFP & public hospitals’ annual medians show expense growth topping revenues for second year reports that: Expense growth continues to outpace revenue growth for US not-for-profit and public hospitals, and the widening gap places the sector on an unsustainable path. This is the second consecutive year expenses have topped revenues, and will remain the largest strain on NFP hospital profitability through 2019.
The report said, Revenue pressures continue to overshadow expense saving initiatives, while the median annual expense growth rate decelerated to 5.7% from 7.1%, but, annual revenue growth rate declined faster, to 4.6% from 6.1%."
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